Peripheral Intravenous Line Survival and Phlebitis Prevention in Patients Receiving Intravenous Antibiotics: Heparin/Hydrocortisone versus In-Line Filters

Abstract

The effectiveness of i.v. filters in excluding the large particle load introduced by i.v. antibiotics and hence in reducing the subsequent phlebitis makes them a useful alternative to the use of hep/hc. The use of filters in this patient group may offer advantages in terms of ease of use and a possible decrease in hep/hc-related problems. Long lines offer practical advantages over short lines for patients requiring longer term i.v. access.

Peripheral long lines in cystic fibrosis

“…course. Mean survival time for both cannulae was similar and comparable with other reports (1,(3)(4)(5).…”

Influence of Vancomycin Infusion Methods on Endothelial Cell Toxicity

“…Studies have shown that i.v. antibiotics, such as vancomycin, amphotericin B, and especially ␤-lactam have been associated with a 2-fold increase in the risk of phlebitis, which may be attributed to the presence of microparticles in the antibiotic solution (31,32) capable of inducing an inflammatory response in Percentage of HUVECs surviving a 24 h contact with vancomycin solution at 5 mg/ml (pH 7.15) or 7.5 mg/ml (pH 6.96), compared to 0.9% NaCl solution at the same pH. *, P Ͻ 0.05.…”

Endothelial Cell Toxicity of Vancomycin Infusion Combined with Other Antibiotics

“…The acidic pH of vancomycin might be modified during the blending process, altering the stability of the drug and possibly causing precipitation (12). The endothelial toxicity of vancomycin when combined with other drugs may be attributed to the presence of microparticles in the antibiotic solution (21,22). Studies have found that i.v.…”

“…Studies have found that i.v. antibiotics, such as vancomycin, amphotericin B, and especially ␤-lactam, are associated with a twofold increase in the risk of phlebitis, which may be due to the presence of microparticles in the antibiotic solution that are capable of inducing both an inflammatory response in HUVEC and cell apoptosis (21,22). A study has already associated the systemic inflammatory response syndrome (SIRS) with the presence of microparticles (23).…”