Peripheral Joint Injections

Marcolina, Austin; Vu, Kevin; Chien, George C. Chang

doi:10.1016/j.pmr.2022.01.005

Cited by 3 publications

(4 citation statements)

References 175 publications

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“…In the field of rheumatology, HA has garnered substantial attention, owing to its pivotal involvement in joint health and its relevance to diseases like osteoarthritis (OA) and rheumatoid arthritis (RA) [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid in Rheumatology

Sprott,

Fleck

2023

Pharmaceutics

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Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 million Dalton (Da), equivalent to roughly 20,000 disaccharide monomers; although some sources report a lower range of 3–4 million Da. In recent years, HA has garnered significant attention in the field of rheumatology due to its involvement in joint lubrication, cartilage maintenance, and modulation of inflammatory and/or immune responses. This review aims to provide a comprehensive overview of HA’s involvement in rheumatology, covering its physiology, pharmacology, therapeutic applications, and potential future directions for enhancing patient outcomes. Nevertheless, the use of HA therapy in rheumatology remains controversial with conflicting evidence regarding its efficacy and safety. In conclusion, HA represents a promising therapeutic option to improve joint function and alleviate inflammation and pain.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid in Rheumatology

Sprott,

Fleck

2023

Pharmaceutics

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“…PRP is widely used in the treatment of various diseases, including case report of treatment in crystal-related arthritis, but outcomes are inconsistent. 5 We intend to report a 34-year-old man, employed in a bar and habitually consuming alcohol for over 10 years, reported an 8-year history of polyarthralgia. He was admitted due to a persistently rupturing wound on his left foot, which had been worsening for 10 days.…”

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confidence: 99%

Use of platelet‐rich plasma in treating a wound infection following tophi rupture: A case report

Mu,

Shih,

Zhong

et al. 2024

Int J of Rheum Dis

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Gout is a common crystal-related joint disease that result from the deposition of monosodium urate in the joint space. Gouty arthritis is a metabolic disease that could be stratified with the activity of the disease into asymptomatic gout, acute gout, interval gout, and chronic tophaceous gout. 1 Tophus formation contains a large number of monosodium urate crystals and surrounding inflammatory cells and connective tissue. The development of tophus is common in patients with uncontrolled serum urate and leads to severe and chronic gout. 2 The formation of subcutaneous tophus leads to erosion of surrounding bone and the soft tissues and development of a yellow-white neoplasm. In severe cases, tophi could result in joint deformities, bone destruction, skin ulcers, and discharge of powdery or pasty substances from wounds; thus, the wound healing is a difficult challenge. 3 Ensuring the proper wound management leads to successful treatment of ruptured tophus.Platelet-rich plasma (PRP) is a high-concentration platelet plasma obtained by centrifugation based on the difference of sedimentation coefficient of whole blood components. 4 PRP contains 3-6 times platelet compared to the baseline in plasma and various biologically active substances such as cytokines that promote tissue repair and regeneration. PRP is widely used in the treatment of various diseases, including case report of treatment in crystal-related arthritis, but outcomes are inconsistent. 5 We intend to report a 34-year-old man, employed in a bar and habitually consuming alcohol for over 10 years, reported an 8-year history of polyarthralgia. He was admitted due to a persistently rupturing wound on his left foot, which had been worsening for 10 days. At initial, he observed a painful, swollen, erythematous lump on his left foot, which ruptured, discharging white material, and leading to an expanding wound. Despite the debridement and antibiotics

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“…Для ЛИТ применяются препараты и биологически активные субстанции с различным механизмом действия, такие как глюкокортикоиды (ГК), препараты гиалуроновой кислоты (ГлК), аутологичная обогащенная тромбоцитами плазма (ОТП), ботулинический токсин типа А (БТА) и др. [1][2][3][4][5][6]. Важным преимуществом ЛИТ является относительно низкая частота системных нежелательных реакций (НР).…”

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“…Представляем проект рекомендаций по использованию ЛИТ для лечения БКМС с соответствующей оценкой уровней доказательности (УД -от 1 до 5) и уровней убедительности рекомендаций (УУР -А, В, С; табл. [1][2][3].…”

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Local injection therapy in the complex treatment of musculoskeletal disorders: principles of application, evidence base, safety

Lila,

Zagorodniy,

Karateev

et al. 2023

Sovremennaâ revmatologiâ

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Local injection therapy (LIT) is an important component of the complex treatment of musculoskeletal disorders (MSD), which is widely used in real clinical practice. Glucocorticoids, hyaluronic acid drugs (HA), autologous cell drugs, botulinum toxin type A, radioactive isotopes, etc. are used for LIT. LIT makes it possible to achieve a pronounced symptomatic effect, while in some cases, for example, repeated HA treatments in patients with osteoarthritis, the possibility of slowing the progression of the disease and reducing the need for surgical treatment is discussed.The performance of LIT requires special skills and abilities of the physician, careful compliance with the rules of asepsis and antisepsis, and instrumental visualization. LIT can be associated with serious complications and therefore must be performed according to strict indications.The Expert Council was devoted to defining the basic principles of LIT. The indications for the use of certain types of this therapies, the evidence base for its efficacy and safety, the order of application of different drugs, and the need to combine LIT with other drug and non-drug treatments of MSD were reviewed.

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Peripheral Joint Injections

Cited by 3 publications

References 175 publications

Hyaluronic Acid in Rheumatology

Hyaluronic Acid in Rheumatology

Use of platelet‐rich plasma in treating a wound infection following tophi rupture: A case report

Local injection therapy in the complex treatment of musculoskeletal disorders: principles of application, evidence base, safety

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