Peripheral large granular lymphocytes in normal pregnant and postpartum women: Decrease in late pregnancy and dynamic change in the puerperium

Iwatani, Yoshinori; Amino, Nobuyuki; Kabutomori, Osamu; Kaneda, T; Takahashi, Osamu; Miyai, Kiyoshi

doi:10.1016/0165-0378(89)90025-9

Cited by 12 publications

(5 citation statements)

References 26 publications

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“…This change in the Hoshimoto/Hayashi/Ohkura CD26/CD30 ratio in the third trimester (CD30+ lymphocyte dominance) might be consistent with previous reports that maternal cellular immunity decreased in late pregnancy [20,30]. In conclusion, our study suggests that sCD26 and CD30 are potent markers; however, expressions of CD26 and CD30 by total lymphocyte (not divided into CD4+ and CD8+) are not useful markers for Th1/Th2 balance during pregnancy.…”

Section: Discussionsupporting

confidence: 73%

CD26 and CD30 Expression on the Surface of Lymphocyte during Normal Pregnancy

Hoshimoto

Hayashi

Ohkura

2001

Gynecol Obstet Invest

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It is increasingly apparent that the Th1/Th2 cell ratio is decreased during pregnancy. In a previous study, we revealed that combined analysis of soluble CD26 and CD30 might be a potent surrogate tool for evaluating the Th1/Th2 balance during pregnancy. Therefore, in the present study, we elucidated whether the CD26 and CD30 expression on the surface of lymphocyte is useful marker for Th1 and Th2 lymphocytes, respectively, during pregnancy with flow cytometric technique. The peripheral blood samples were obtained from 6 non-pregnant healthy women, 8 healthy pregnant women in the first trimester and 12 pregnant women in the third trimester. The mean percentages of CD26 expression did not differ significantly among these groups (p = 0.45). Also, the mean percentages of CD30 expression did not differ significantly among these groups (p = 0.32). From the present study, the expression of CD26 and CD30 did not appear to be a useful marker for Th1 and Th2 lymphocytes during pregnancy.

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Section: Discussionsupporting

confidence: 73%

CD26 and CD30 Expression on the Surface of Lymphocyte during Normal Pregnancy

Hoshimoto

Hayashi

Ohkura

2001

Gynecol Obstet Invest

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“…Although the markers of inflammation decrease soon thereafter, the immune system remains activated throughout the first year postpartum. Proinflammatory cytokines, immune cells, and APPs have been shown to be elevated for up to 1 y postpartum (10,(24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Plasma Ferritin and Hepcidin Are Lower at 4 Months Postpartum among Women with Elevated C-Reactive Protein or α1-Acid Glycoprotein

et al. 2017

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Ferritin and hepcidin are markers of iron status that typically increase during inflammation or infection. The postpartum period is a physiologically unique life stage in which the relations between these proteins and other markers of inflammation have not been extensively studied. We aimed to determine whether 2 markers of inflammation [high-sensitivity C-reactive protein (CRP) and α1-acid glycoprotein (AGP)] were associated with ferritin or hepcidin in postpartum women in California. This is a secondary analysis of a randomized controlled iron-intervention trial. Plasma CRP, AGP, ferritin, and hepcidin were analyzed at 2 and 17 wk postpartum in 114 lactating women. We examined Pearson correlation coefficients between all biomarkers at both time points and differences in mean values of ferritin and hepcidin between those with and without elevated CRP and/or AGP. At 2 and 17 wk postpartum, 58% and 26% of women had CRP >5 mg/L and 78% and 29% had AGP >1 g/L, respectively. Neither CRP nor AGP was significantly correlated with ferritin ( = 0.07 and -0.06; = 114 at 2 wk; -0.14 and -0.14; = 95 at 17 wk) or hepcidin ( = 0.18 and -0.03 at 2 wk; -0.05 and -0.14 at 17 wk; > 0.05 for all). At 2 wk, geometric mean plasma ferritin and hepcidin concentrations did not differ between women with and without elevated CRP or AGP ( > 0.5), but at 17 wk women with elevated CRP or AGP had lower mean (95% CI) ferritin and hepcidin than did women without either elevated CRP or AGP [ferritin: 30.3 ng/mL (23.4, 39.1 ng/mL) compared with 40.2 ng/mL (32.9, 49.2 ng/mL); < 0.01; hepcidin: 44.3 ng/mL (32.3, 60.9 ng/mL) compared with 67.6 ng/mL (56.1, 81.5 ng/mL); = 0.02]. Lower ferritin and hepcidin among women with elevated CRP or AGP at 17 wk postpartum suggests that these markers of iron status react differently to physiologic immune activation than to pathologic inflammatory states.

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“…However, the Kurloff cell differs from the azurocyte in that it can be induced with estrogen (Ledingham 1940), while AZ are induced by progestins (Mihok & Schwartz 1991a). The Kurloff cell has NK activity (Eremin et al 1980), as have other cells also associated with pregnancy in other mammals: large granular lymphocytes (LGLs) of humans (Iwatania et al 1989) and uterine NK cells of rodents (Head 1996). Based on similarities with LGLs and Kurloff cells, it was suggested that AZ are an NK cell unique to the vole (Mihok & Schwartz 1991b), and it was proposed that its function could be maintaining immunocompetence during pregnancy or maintaining the survival of embryos/foetuses.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, large granular lymphocytes of the NK lineage increase in peripheral blood during the first trimester of pregnancy (Iwatania et al 1989), and similar cells also appear in the human endometrium at embryonic implantation (King et al 1989;Bulmer et al 1991). Also during pregnancy, murine and microtine rodents also present special NK cells (formerly known as Granulated Metrial Gland cells and currently as uterine NK cells), but they have been found generally in the uterine glands, not circulating (Head 1996;Stewart & Clarke 1999), although their bone marrow origin has been confirmed (Stewart 1991).…”

Section: Discussionmentioning

confidence: 99%

Azurocytes in Wild Field Voles: Factors Associated with Their Occurrence

et al. 2008

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The occurrence of azurocytes (AZ), a type of leukocyte unique to voles and previously described for three Microtus species, is now reported in Microtus agrestis. The goal of this study was to shed new light on the possible function and significance of these cells and on how they play a role in the natural history of rodent species. Individuals from three vole populations were sampled monthly for 2 years. A hemogram was produced for each individual, and AZ counts estimated. The counts of AZ were much higher in pregnant females, and these levels were higher the higher the past vole density. Males had low prevalences and counts, both for breeding and nonbreeding individuals, but they showed a seasonality that varied with age, body condition, and current and past vole density. Also, the occurrence of AZ in males was more likely after they had had low levels of indicators of condition, suggesting that azurocytes may result from a response to infection. Hence, overall our results suggest that, in females, these cells may be important for reproduction and may have a role in inducing abortion when conditions are not favorable, while in males they might be a response to infection.

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Peripheral large granular lymphocytes in normal pregnant and postpartum women: Decrease in late pregnancy and dynamic change in the puerperium

Cited by 12 publications

References 26 publications

CD26 and CD30 Expression on the Surface of Lymphocyte during Normal Pregnancy

CD26 and CD30 Expression on the Surface of Lymphocyte during Normal Pregnancy

Plasma Ferritin and Hepcidin Are Lower at 4 Months Postpartum among Women with Elevated C-Reactive Protein or α1-Acid Glycoprotein

Azurocytes in Wild Field Voles: Factors Associated with Their Occurrence

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