“…Urinary LT-E4 levels were found to increase in patients with inflammatory bowel diseases, especially during periods of active mucosal inflammation, suggesting that non-invasive measurements of urinary LT-E4 levels may indicate disease activation and that these patients may benefit from treatment with leukotriene inhibitors (23). A study measuring peripheral inflammatory mediators, including LT-B4, PG-E2 and thromboxane B2, in migraine patients showed that LT-B4 levels were lower during pain-free periods than during headaches (24). Concentrations of LT-B4 and LT-C4, which have been implicated in migraine pathophysiology, were found to increase during migraine episodes but to be normal between episodes (25).…”