Peripheral lung cancers arising in scars

Yokoo, Hidejiro; Suckow, Earl E.

doi:10.1002/1097-0142(196111/12)14:6<1205::aid-cncr2820140610>3.0.co;2-2

Cited by 93 publications

(15 citation statements)

References 7 publications

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“…Owing to further research performed in the 1940s, there was a subsequent evolution in the understanding of SC and the following clinical features were then thought to make the diagnosis of SC more likely: the tumour is peripherally located with a size of less than 3 cm in diameter, upper-lobe predominance, more commonly found in males, and usually of ADC histological subtype. [20][21][22] A large cohort analysis of the prostate, lung, colorectal and ovarian cancer screening trial demonstrated a clear correlation between scar presence and the development of a carcinoma. [23] Cigarette smoking has long been known to be associated with chronic lung destruction and the development of lung cancer.…”

supporting

confidence: 57%

A 2-year retrospective review of the effect of cigarette smoking status on the histological cell types of lung carcinoma in the Western Cape

Pellizzon¹,

Koegelenberg²,

Irusen³

2015

S Afr Res J

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Background. Cigarette smoking is variably associated with the various histological cell types of lung cancer. The primary aim of this study was to analyse various strengths of association between the common histological cell types of lung cancer and smoking in a Western Cape population. The secondary aim examined whether an association exists between scar carcinoma and smoking. Methods. We retrospectively analysed the records from 386 patients over a 2-year period. Both smokers and non-smokers were subdivided and analysed as two groups, which included those with non-small cell and small cell lung cancer. Smokers and non-smokers were also analysed separately according to the presence or absence of lung scarring. Results. In total, 94.3% of all patients with lung cancer were current or past smokers. There was a disproportionately higher number of patients with adenocarcinoma who were non-smokers compared with all the other cell types (p=0.01), whereas patients with squamous cell carcinoma were more likely to be smokers (p=0.05). Although the vast majority of patients with and without lung scars were found to be smokers (96.4% v. 93.7% respectively), there was no statistically significant difference found between these two groups (p=0.43). Conclusion. In a Western Cape population, patients with adenocarcinoma were more likely to be non-smokers, while those with squamous cell carcinoma were relatively more likely to be smokers. No clear association between scar carcinoma and smoking status was found.

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supporting

confidence: 57%

A 2-year retrospective review of the effect of cigarette smoking status on the histological cell types of lung carcinoma in the Western Cape

Pellizzon¹,

Koegelenberg²,

Irusen³

2015

S Afr Res J

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“…[43][44][45] From a pathological viewpoint it appears that despite their lower proliferative activity, centrally located tumor cells still retain their malignant potential as ascertained by such criteria as vascular invasiveness. 13,46 Although one explanation for this biological aggressiveness may be the abundance of capillaries and lymph vessels in the center, the discrepancy between proliferative capability and high invasiveness should be elucidated by future study.…”

Section: Discussionmentioning

confidence: 99%

Tumor Extension and Cell Proliferation in Adenocarcinomas of the Lung

Shoji

Dobashi

Morinaga

et al. 1999

The American Journal of Pathology

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To elucidate the mechanism of tumor extension in human pulmonary adenocarcinoma , we immunohistochemically investigated the expression of cell cycle regulator proteins in 54 small adenocarcinomas less than 3 cm in diameter. The Ki-67-labeling index was significantly higher in the periphery of the tumor nodule than in the center. This proliferative potential correlated well with coexpression of cdk2 and cyclin A. p27 , one of the cdk inhibitors , was highly expressed in normal bronchial epithelial cells. Peripherally located tumor cells expressed p27 at an intermediate level , but at a higher frequency and level than those in the center. Expression of p21 was also predominant in the periphery. Furthermore , the expression patterns of p21 and p27 were reciprocal. Adenocarcinoma is the most common histological subtype of lung carcinoma and its incidence is increasing.

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“…In another study, the proper treatment of 45 of 64 lung cancers was delayed a minimum of two months because of being incorrectly diagnosed as pulmonary tuberculosis (25). Carcinoma tends to develop in parenchymal scars (20,22,29), more often following pulmonary tuberculosis than in non-tuberculous lesions (6,18).…”

Section: Discussionmentioning

confidence: 99%

Problems in Radiographic Detection and Diagnosis of Lung Cancer

Hayabuchi¹,

Russell²,

Murakami³

1989

Acta Radiol

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All chest radiographs of 107 proven lung cancer patients who received consecutive biennial chest radiography were reviewed to elucidate problems detecting their cancers, and diagnosing them when initially radiographically detected. Subjects, members ofa fixed population sample, originally numbered 20000 persons, 17000 of whom consistently received consecutive biennial chest radiography during examinations for late effects of atomic-bomb radiation. Among the 107 subjects, 64 had radiographic manifestations of cancer; 47 were initially correctly diagnosed; 17 were not. Eleven of the 17 were initially equivocal, diagnosable only after subsequent radiography and retrospective review of serial radiographs. Diagnostic problems consisted of I) six detection errors with cancer images superimposed on musculoskeletal and cardiovascular structures, reducible by stereoscopic p.a. instead of single p.a. radiography; immediate tentative interpretations; and by comparing earlier with current radiographs. 2) Eight decision errors, wherein cancers mimicked other diseases, were reducible by greater index of suspicion and scrutiny during interpretations.

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Peripheral lung cancers arising in scars

Cited by 93 publications

References 7 publications

A 2-year retrospective review of the effect of cigarette smoking status on the histological cell types of lung carcinoma in the Western Cape

A 2-year retrospective review of the effect of cigarette smoking status on the histological cell types of lung carcinoma in the Western Cape

Tumor Extension and Cell Proliferation in Adenocarcinomas of the Lung

Problems in Radiographic Detection and Diagnosis of Lung Cancer

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