Peripheral median nerve stimulation for the treatment of iatrogenic complex regional pain syndrome (CRPS) type II after carpal tunnel surgery

Median Nerve Stimulation as a Nonpharmacological Approach to Bypass Analgesic Tolerance to Morphine: A Proof-of-Concept Study in Mice

“…6 The stable antiallodynic effect of MNS-PC6 during the treatment period suggests that tolerance does not develop. This is in-line with previous clinical reports that electrical stimulation at the median nerve, either by a surgically-implanted electrode 35,67 or by percutaneous stimulation, 66 effectively relieved chronic pain without tolerance. 65 In certain cases, MNS even provided pain relief for years 3,36,39 or decades.…”

Ultrasound-Guided Peripheral Nerve Stimulator Placement in Two Soldiers with Acute Battlefield Neuropathic Pain

“…14,19,20 PNS benefit is thought to stem from interruption of A-␦ and C fiber signaling. 21,22 Our experience with these 2 patients was similar to what Huntoon and Burgher. 16 described as a "small therapeutic window" in relation to PNS.…”

Evidence-Based Review of Neuromodulation for Complex Regional Pain Syndrome: A Conflict Between Faith and Science?

“…Monti published a case report of a percutaneous lead implant for CRPS type II , while Mirone et al. published a similar case using a paddle‐type lead . Unfortunately, there are no contemporary studies using contemporary PNS techniques for CRPS.…”

“…I approached my daunting task by performing both PubMed and GoogleScholar searches using MeSH terms for each of the major neuromodulation modalities plus RSD or CRPS. I identified notable articles for the following modalities: peripheral nerve stimulation (PNS) ( N = 5) , SCS ( N = 34) , motor cortex stimulation (MCS) ( N = 2) , deep brain stimulation (DBS) ( N = 7) , and intraspinal drug administration ( N = 21) . As dispassionately as possible, I present my analysis of these articles below.…”