Peripheral Monocyte Count and Age-Related Macular Degeneration. The Tongren Health Care Study

Xue, Can Can; Cui, Jing; Gao, Li; Chun, Zhang; Dou, Hong-Liang; Chen, Dong Ning; Wang, Ya Xing; Jonas, Jost B

doi:10.1016/j.ajo.2021.03.010

Cited by 13 publications

(7 citation statements)

References 45 publications

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“…In addition, the individuals were ophthalmologically examined, and fundus photographs (non-mydriatic 45° fundus camera, Topcon camera TRG-NW7SF (Topcon Co., Tokyo, Japan), or Cannon camera CR6-45NM (Canon Co., Tokyo, Japan) were taken. The design of the study has been described in detail previously [19]. Arterial hypertension was defined as a systolic blood pressure of ≥140 mm Hg or a diastolic blood pressure of ≥90 mm Hg, or a history of physician-based diagnosis of hypertension history or use of antihypertensive medication.…”

Section: Methodsmentioning

confidence: 99%

Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study

Gao,

Xue,

Cui

et al. 2023

Am J Nephrol

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Introduction: To investigate associations between diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with type 2 diabetes (DT2). Methods: The participants of the cross-sectional, community-based Tongren Health Care Study underwent a detailed medical and ophthalmological examination. We defined DT2 by a fasting plasma glucose concentration of ≥7.0 mmol/L or a medical history. CKD was classified as either reduced estimated glomerular filtration rate (eGFR) of <60ml/min/1.73mm2, or presence of albuminuria. DR was assessed using color fundus photographs. Results: Out of 62,217 participants of the Tongren Health Care Study, 5103 (8.2%) patients had DT2. The prevalence of DR was 12.8% (95%CI, 11.8%, 13.7%), CKD was 13.3% (95%CI,12.4%, 14.3%), and the subtypes of CKD, including reduced eGFR and albuminuria was 4.6% (95%CI, 4.2%, 5.1%), and 10.1% (95%CI, 9.3%, 10.9%), respectively. DR was detectable in 21.0% of the patients with CKD, while CKD present in 20.9% of the DR patients. Higher DR prevalence was associated with higher prevalence of albuminuria and reduced eGFR (both P<0.05). Factors independently associated with the presence of CKD instead of DR were older age (P<0.001, OR=1.05), a higher body mass index (P<0.001, OR=1.14), a higher serum concentration of triglycerides (P<0.001, OR=1.26), and a lower blood glucose (P<0.001, OR=0.93). Having hypertension was additionally associated with the presence of reduced eGFR as compared with DR (P=0.005, OR=4.47). Conclusions: TD2 patients of older age and with higher body mass index, hypertension and dyslipidemia had a higher probability of being affected by CKD rather than DR, while those with a higher blood glucose level were more prone to DR than CKD.

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Section: Methodsmentioning

confidence: 99%

Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study

Gao,

Xue,

Cui

et al. 2023

Am J Nephrol

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“…The cross-sectional, community-based Tongren Health Care Study included individuals who attended regular health care check-up examinations in the Beijing Tongren Hospital from July 2017 to December 2019. The study population has been described in detail recently (13). The eligibility criterion for inclusion into the current study was an age of 18+ years.…”

Section: Methodsmentioning

confidence: 99%

Serum Sodium Concentration and Increased Risk for Primary Epiretinal Membrane

et al. 2021

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Aims: To examine the prevalence of primary epiretinal membranes (ERMs) and associated systemic factors.Methods: The cross-sectional, community-based Tongren Health Care Study enrolled participants who received regular health examinations in the Beijing Tongren Hospital from 2017 to 2019. Using fundus photographs, retinal specialists assessed the presence of ERMs and their systemic associations.Results: Primary ERMs were detected in 841/22820 individuals, with a prevalence of 3.7% [95% confidence intervals (CI): 3.4–3.9%] in the total study population (mean age: 44.5 ± 13.8 years) and 6.5% (95% CI: 6.1–7.0%) in individuals aged 40+ years. In multivariable analysis, a higher ERMs prevalence was associated with older age [odds ratio (OR): 1.10; P < 0.001], higher serum cholesterol concentration (OR: 1.14; P = 0.003) and higher serum sodium concentration (SSC) (OR: 1.12; P < 0.001). In women, a higher SSC, even within the normal range, was associated with an increased risk of ERMs (OR: 1.19; P < 0.001). Female participants with an SSC of 144–145mmol/L as compared with those with an SSC of 135–137 mmol/L had a 5-fold increased odds of having ERMs (All women: OR: 5.33; P < 0.001; Women aged 40+years: OR: 4.63; P < 0.001).Conclusion: Besides older age and higher serum cholesterol concentration, a higher SSC, even if within the normal range, was independently associated with a higher ERM prevalence in women.

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“…Monocyte-derived macrophages, as aforementioned, appear to play a role in AMD, but the primary difference between these two cells is their localization; monocytes circulate in the bloodstream where macrophages infiltrate tissue. Peripheral monocyte counts, in particular, have been shown to be higher in AMD patients versus controls (Xue et al, 2021). In intermediate and advanced AMD, monocyte phagocytic function is shown to be reduced about 40% across several monocyte subtypes compared to controls (Gu et al, 2021).…”

Section: Monocytesmentioning

confidence: 96%

Innate immune biology in age-related macular degeneration

Ascunce

Dhodapkar²,

Huang³

et al. 2023

Front. Cell Dev. Biol.

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Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.

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Peripheral Monocyte Count and Age-Related Macular Degeneration. The Tongren Health Care Study

Cited by 13 publications

References 45 publications

Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study

Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study

Serum Sodium Concentration and Increased Risk for Primary Epiretinal Membrane

Innate immune biology in age-related macular degeneration

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