“…A sciatic nerve injection injury may present in three ways: as immediate neuropa thy with instantaneous pain, immediate neu ropathy without instantaneous pain, or de layed paralysis [10,18,19], It was once believed that the injected chemical could dif fuse to the nerve from a distant, properly selected site [10], but this does not occur in cadaver studies [5,18,19], Animal studies indicate that intraneural injection is neces sary and mere perineural injection is insuffi cient to produce nerve damage [2,3,17], The type of chemical is also important [2,3,17], but mechanical trauma of the needle tip alone may cause damage to nerve fascicles [11,13], Needle trauma may produce typically local ized damage as can be seen in injuries occur ring during brachial plexus anesthesia [13].…”