Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components

Wang, Xinghui; Yang, Miao; Ni, Jun; Wang, Yaxian; Qian, Tianmei; Yu, Jun; Liu, Qianyan; Wang, Pan; Yi, Sheng

doi:10.3389/fphys.2018.01519

Cited by 14 publications

(10 citation statements)

References 38 publications

(47 reference statements)

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“…In vivo studies in mutants lacking MMP-9 indicate that MMP-9 activity during axonal degeneration is crucial to promote myelin sheath collapse and to prompt the blood-nerve-barrier breakdown allowing the influx of immune cells into the nerve (Shubayev and Myers, 2000; Chattopadhyay et al, 2007; Kobayashi et al, 2008). More recent studies have implicated also MMP-9, together with MMP-7, in regulating claudin proteins expression at the tight junction in nerves after crush injury, suggesting that high levels of MMPs might alter nerve physical barriers (Wang et al, 2018). Further, MMP-9 stimulates the rearrangement of the basal lamina (La Fleur et al, 1996; Hartung and Kieseier, 2000; Platt et al, 2003; Shubayev et al, 2006; Chattopadhyay et al, 2007; Kobayashi et al, 2008).…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1

Pellegatta

Taveggia

2019

Front. Cell. Neurosci.

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After damage, axons in the peripheral nervous system (PNS) regenerate and regrow following a process termed Wallerian degeneration, but the regenerative process is often incomplete and usually the system does not reach full recovery. Key steps to the creation of a permissive environment for axonal regrowth are the trans-differentiation of Schwann cells and the remodeling of the extracellular matrix (ECM). In this review article, we will discuss how proteases and secretases promote effective regeneration and remyelination. We will detail how they control neuregulin-1 (NRG-1) activity at the post-translational level, as the concerted action of alpha, beta and gamma secretases cooperates to balance activating and inhibitory signals necessary for physiological myelination and remyelination. In addition, we will discuss the role of other proteases in nerve repair, among which A Disintegrin And Metalloproteinases (ADAMs) and gamma-secretases substrates. Moreover, we will present how matrix metalloproteinases (MMPs) and proteases of the blood coagulation cascade participate in forming newly synthetized myelin and in regulating axonal regeneration. Overall, we will highlight how a deeper comprehension of secretases and proteases mechanism of action in Wallerian degeneration might be useful to develop new therapies with the potential of readily and efficiently improve the regenerative process.

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Section: Matrix Metalloproteinasesmentioning

confidence: 99%

The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1

Pellegatta

Taveggia

2019

Front. Cell. Neurosci.

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“…Tight junctions might be related to these findings because reports in the field of dermatology have shown that tight junctions in the skin epithelium are disrupted by neuropathy [26]. However, this requires further research.…”

Section: Discussionmentioning

confidence: 92%

Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy

Oba

Araki-Sasaki

Chihara

et al. 2022

JCM

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The characteristic features of neurotrophic keratopathy have been well documented by in vivo and in vitro studies using animal models. However, case reports of neurotrophic keratopathy induced by neurosurgery are limited. We describe the clinical characteristics, anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) findings of neurotrophic keratopathy induced by surgery for intracranial lesions. This is a case series including 6 eyes of 3 patients (mean age, 69.67 ± 12.50 years) with unilateral neurotrophic keratopathy. The clinical findings of three patients were described and IVCM findings of three patients were analyzed. The duration of neuropathy ranged from 2 to 30 years (median, 22 years). Thickening of the epithelial layer and higher reflection density of the anterior stroma were observed during the healing process using AS-OCT. The mean nerve fiber density of the subepithelial plexus, as determined by IVCM, was 1943 ± 1000 μm/mm2 for neurotrophic eyes and 2242 ± 600.3 μm/mm2 for contralateral eyes (p = 0.0347). The mean respective dendritic cell densities were 30.8 ± 21.8 and 6.25 ± 5.59 cells/mm2 (p < 0.0001), while the mean basal cell sizes were 259 ± 86.5 and 185 ± 45.9 μm2 (p < 0.0001), respectively. These findings suggest that neurosurgery-induced neurotrophic keratopathy may be associated with alterations in the healing process and immune cell distribution in the cornea.

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“…The improving effects of A. oxyphylla and Schisandra chinensis (Schisandraceae) fruit (1:1) extract (chloroform fraction of 95% ethanol extract, 1200 mg/kg, orally administered for 30 days) were evaluated using scopolamine (3 mg/kg for nine days) to induce learning and memory impairments in an AD mouse model (Wang et al, 2018). After, Y-maze test and Morris water maze test were carried out to observe the behavior of KM mice.…”

Section: )mentioning

confidence: 99%

“…In addition, the treatment with the extract was able to increase the level of ACh and M1 receptors, and decrease AChE activity, but it did not affect choline acetyltransferase activity. The authors hypothesized that the extract may interfere in the Aβ pathological mechanism, and then play a role in neuroprotective effects on AD (Wang et al, 2018).…”

Section: )mentioning

confidence: 99%

Therapeutic potential of Zingiberaceae in Alzheimer's disease

Bortolucci¹,

Trettel²,

Bernardi³

et al. 2020

BLACPMA

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Alzheimer's disease is the most common form of dementia and is highly prevalent in old age. Unlike current drugs, medicinal plants can have preventive and protective effects with less side effects. Given the great number of bioactive substances, plants from the Zingiberaceae Family have medicinal potential and currently are widely studied regarding its anti-Alzheimer's disease effects. The objective of this study was to provide an overview of advances in phytochemical composition studies, in vitro and in vivo pharmacological studies, and toxicological effects of the Zingiberaceae Family on Alzheimer's disease. Information was obtained from relevant papers in electronic databases. Most of the studies of Zingiberaceae effects on Alzheimer's disease pathogenesis theory are related to cholinergic, β amyloid cascade, tau, inflammation, and oxidative stress hypothesis. Also, in vitro and in vivo preclinical studies on the effect of Alpinia, Curcuma, and Zingiber genera have been reported as harmless and safe, with potential for anti-Alzheimer treatment.

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Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components

Cited by 14 publications

References 38 publications

The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1

The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1

Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy

Therapeutic potential of Zingiberaceae in Alzheimer's disease

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