Peripheral nerve involvement in sarcoidosis: an electrodiagnostic study.

Challenor, Yasoma; Felton, Charles P.; Brust, John C.M.

doi:10.1136/jnnp.47.11.1219

Cited by 32 publications

(14 citation statements)

References 8 publications

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“…Estimates of the incidence of peripheral nerve involvement in sarcoidosis vary widely. There is pathologic or electrophysiological evidence of peripheral neuropathy even in asymptomatic cases, although these are not typically investigated in practice 4–7, 10. Axonal degeneration is far more prominent than demyelination based on electrodiagnostic studies, which is consistent with the infiltrative granulomatous process seen pathologically 4, 7.…”

Section: Discussionmentioning

confidence: 79%

“…Nervous system involvement has been reported in up to 4% of patients with sarcoidosis, of whom 70% present initially with neurological symptoms 1–3. Among sarcoidosis patients without neurological symptoms, at least one third will have subclinical evidence of nervous system involvement on pathologic review at autopsy 4–6. Cranial neuropathies are the most common neurological manifestations of sarcoidosis.…”

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confidence: 99%

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A case of sensory ataxia as the presenting manifestation of neurosarcoidosis

et al. 2011

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Sarcoidosis rarely selectively affects the cauda equina with characteristic motor and sensory impairments.Using imaging, we report a case of cauda equina polyradiculopathy presenting with progressive sensory ataxia without clinical or electrophysiological evidence of motor involvement. Neurosarcoidosis was diagnosed pathologically by proximal dorsal root biopsy after systemic investigations for inflammatory, infectious, and neoplastic etiologies were found to be negative. There was clinical and radiographic improvement with corticosteroids. In addition, we review previously reported cases of cauda equina sarcoidosis.

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Section: Discussionmentioning

confidence: 79%

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confidence: 99%

A case of sensory ataxia as the presenting manifestation of neurosarcoidosis

et al. 2011

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“…Postmortem studies, such as the one published by Iwai et al, 16 suggest that antemortem diagnosis of central nervous system involvement is only made in one-half of the patients with sarcoidosis. Furthermore, in the electrophysiological studies reported by Challenor et al, 17 with 2 of 29 age-matched controls. Sensory evoked potential studies showed abnormally low sensory amplitudes in at least 1 peripheral nerve examined, although EMG and nerve conduction studies were normal.…”

Section: Discussionmentioning

confidence: 94%

Neurosarcoidosis Presenting as Guillain-Barré-Like Syndrome. A Case Report and Review of the Literature

Fahoum¹,

Drory²,

Issakov³

et al. 2009

Journal of Clinical Neuromuscular Disease

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Sarcoidosis is a multisystem inflammatory disease that can affect the nervous system. Cranial neuropathies are the most frequent presentation of neurosarcoidosis. Involvement of the peripheral nervous system is less common. The presentation is usually subacute or chronic sensorimotor axonal polyneuropathy, whereas acute polyradiculopathy is extremely rare. We report a case of Guillain-Barré-like syndrome probably secondary to sarcoidosis. A review of the literature revealed 9 similar cases. The possibility of a Guillain-Barré-like syndrome as a presenting symptom of sarcoidosis should be considered, especially in patients with atypical features such as cerebrospinal fluid pleocytosis.

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“…The frequency of peripheral nerve involvement in sarcoidosis is uncertain but there seem to be many asymptomatic cases 10. Zajicek1 proposed diagnostic criteria with levels of certainty and these criteria are commonly used.…”

Section: Introductionmentioning

confidence: 99%

A rare manifestation of sarcoidosis with sensomotoric neuropathy of the ulnar nerve as the only symptom

et al. 2012

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SUMMARYA 79-year-old woman was admitted complaining of progressive weakness and numbness of the right hand. The patient was otherwise healthy. The patient's history was unremarkable. Clinical and electrophysiological examination revealed a compression of the ulnar nerve in the ulnar sulcus and in Guyon's canal. Ultrasound evaluation showed a suspicious tumour proximal to the elbow close to the ulnar nerve. The ulnar sulcus was then released and an epineural and perineural lesion 3-4 cm proximal to the sulcus was excised under microscope. The histopathology confirmed the lesion as non-caseating sarcoid granulomas. The patient showed no other signs of systemic sarcoidosis, as neuropathy was the only symptom and the condition improved postoperatively. Sensory deficits and paraesthesia resolved fully. The extension of the minor finger remained slightly inferior compared with the not affected side. Sarcoid neuropathy is a rare neurological complication of sarcoidosis and has to be included in differential diagnosis of nerve conduction impairments. BACKGROUND

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Peripheral nerve involvement in sarcoidosis: an electrodiagnostic study.

Cited by 32 publications

References 8 publications

A case of sensory ataxia as the presenting manifestation of neurosarcoidosis

A case of sensory ataxia as the presenting manifestation of neurosarcoidosis

Neurosarcoidosis Presenting as Guillain-Barré-Like Syndrome. A Case Report and Review of the Literature

A rare manifestation of sarcoidosis with sensomotoric neuropathy of the ulnar nerve as the only symptom

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