Peripheral nerve regeneration in the presence of collagen fibers: Effect of removal of the distal nerve stump

Rizvi, Azarn H.; Pins, George D.; Silver, Frederick H.

doi:10.1016/0267-6605(94)90100-7

“…However, nerve regeneration is hindered if these guidance structures are degraded before regenerating axons reach them. On the other hand, the fibers must be fully degraded before nerve regeneration is finished, otherwise complete recovery will be impeded 45 . The muscle fibers inside an MVC 46 are degraded by proteases while simultaneous axon regrowth through the fibrin cable occurs.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of studies comparing muscle-in-vein conduits with autologous nerve grafts for nerve reconstruction

Heinzel

¹

,

Nguyen

²

,

Kefalianakis

³

et al. 2021

Sci Rep

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The gold-standard method for reconstruction of segmental nerve defects, the autologous nerve graft, has several drawbacks in terms of tissue availability and donor site morbidity. Therefore, feasible alternatives to autologous nerve grafts are sought. Muscle-in-vein conduits have been proposed as an alternative to autologous nerve grafts almost three decades ago, given the abundance of both tissues throughout the body. Based on the anti-inflammatory effects of veins and the proregenerative environment established by muscle tissue, this approach has been studied in various preclinical and some clinical trials. There is still no comprehensive systematic summary to conclude efficacy and feasibility of muscle-in-vein conduits for reconstruction of segmental nerve defects. Given this lack of a conclusive summary, we performed a meta-analysis to evaluate the potential of muscle-in-vein conduits. This work’s main findings are profound discrepancies regarding the results following nerve repair by means of muscle-in-vein conduits in a preclinical or clinical setting. We identified differences in study methodology, inter-species neurobiology and the limited number of clinical studies to be the main reasons for the still inconclusive results. In conclusion, we advise for large animal studies to elucidate the feasibility of muscle-in-vein conduits for repair of segmental defects of critical size in mixed nerves.

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“…However, on the one hand, nerve regeneration is hindered if these guidance structures are degraded completely before the regenerating axons reach them. On the other hand, the bers must be completely degraded before nerve regeneration is completed, otherwise this will also impede complete recovery 45 . In case of an MVC the conduit is lled with muscle bers, consisting about 1/5 of protein 46 .…”

Section: Discussionmentioning

confidence: 99%

Nerve reconstruction with muscle-in-vein conduits VS autologous nerve grafts - a systematic review and meta-analysis of preclinical and clinical studies

Heinzel

¹

,

Nguyen

²

,

Kefalianakis

³

et al. 2021

Preprint

1

0

View full text Add to dashboard Cite

The gold-standard method for reconstruction of segmental nerve defects, the autologous nerve graft, has several drawbacks in terms of tissue availability and donor site morbidity. Therefore, feasible alternatives to autologous nerve grafts are sought. Muscle-in-vein conduits have been proposed as an alternative to autologous nerve grafts almost three decades ago, given the abundance of both tissues throughout the body. Based on the anti-inflammatory effects of veins and the proregenerative environment established by muscle tissue, this approach has been studied in various preclinical and some clinical trials. There is still no comprehensive systematic summary to conclude efficacy and feasibility of muscle-in-vein conduits for reconstruction of segmental nerve defects. Given this lack of a conclusive summary, we performed a meta-analysis to evaluate the potential of muscle-in-vein conduits. This work’s main findings are profound discrepancies regarding the results following nerve repair by means of muscle-in-vein conduits in a preclinical or clinical setting. We identified differences in study methodology, inter-species neurobiology and the limited number of clinical studies to be the main reasons for the still inconclusive results. In conclusion, we advise for large animal studies to elucidate the feasibility of muscle-in-vein conduits for repair of segmental defects of critical size in mixed nerves.

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“…10,11,121,[125][126][127] Other systems claimed to be biodegradable, e.g. collagen, [128][129][130][131][132][133][134] poly(hydroxybutyrate) (PHB), 59,135,136 polycaprolactone, 137-142 tyrosine derived polycarbonates (poly-DTE, poly-DTB, poly-DTO), [143][144][145] polyphosphazanes, 146 polydioxanone (PDS), [147][148][149] cellulose derivatives, chitin and chitosan, [150][151][152][153][154][155] polyethylene glycol (PEG), 149,[156][157][158][159] polyvinyl alcohol (PVA), 131,160,161 polyethylene oxide-polybutylene teraphthalate (PEO/PBT) co-polymers, 58,98,162 polypropylene fumarate (PPF), [163][164][165][166] have been proposed, but none has really established itself in the market.…”

Section: Polymeric Systems For Medical Applicationsmentioning

confidence: 99%

Biodegradable polymers and composites in biomedical applications: from catgut to tissue engineering. Part 1 Available systems and their properties

Gomes¹,

Reis²

2004

International Materials Reviews

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Biodegradable polymers form a unique class of materials that created an entirely new concept when originally proposed as biomaterials. That is, for the first time, a material performing a structural application was designed to be completely resorbed and to become weaker over time. This concept was first applied successfully with catgut sutures and later, with more arguable results, on bone fixation plates and pins. Current research on new and improved biodegradable polymers is focused on more sophisticated biomedical applications to solve patients' problems with higher efficacy and the least possible pain. One example is tissue engineering, in which a biodegradable scaffold seeded with an appropriate cell type provides a substitute for damaged human tissue while the natural process of regeneration is completed. An overview is given of the degradation properties and mechanisms of biodegradable polymers, their processability and biocompatibility, focusing on the aspects most relevant to biomedical applications. The main families of biodegradable polymeric systems are described and the systems that are commercially available or that are currently being studied and proposed for specific medical applications are reviewed.

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Peripheral nerve regeneration in the presence of collagen fibers: Effect of removal of the distal nerve stump

Cited by 13 publications

References 15 publications

A systematic review and meta-analysis of studies comparing muscle-in-vein conduits with autologous nerve grafts for nerve reconstruction

A systematic review and meta-analysis of studies comparing muscle-in-vein conduits with autologous nerve grafts for nerve reconstruction

Nerve reconstruction with muscle-in-vein conduits VS autologous nerve grafts - a systematic review and meta-analysis of preclinical and clinical studies

Biodegradable polymers and composites in biomedical applications: from catgut to tissue engineering. Part 1 Available systems and their properties

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