Peripheral nerve stimulation enables somatosensory feedback while suppressing phantom limb pain in transradial amputees

Soghoyan, Gurgen; Biktimirov, Artur; Matvienko, Yu. G.; Chekh, Ilya; Sintsov, Mikhail; Lebedev, Mikhail

doi:10.1016/j.brs.2023.04.017

Cited by 8 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In light of the limitations of pharmacological interventions, neurostimulation is emerging as a promising treatment option to treat PLP, including spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) (Soghoyan et al, 2023). Both SCS and PNS activate afferents fibers while PNS is more selective to influence residual limb nerves (Petersen et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper-limb amputees

Kleeva

Soghoyan

Biktimirov

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Phantom limb pain (PLP) is a distressing and persistent sensation that occurs after the amputation of a limb. While medication-based treatments have limitations and adverse effects, neurostimulation is a promising alternative approach whose mechanism of action needs research, including electroencephalographic (EEG) recordings for the assessment of cortical manifestation of PLP relieving effects. Here we collected and analyzed high-density EEG data in three patients (P01, P02, and P03). Peripheral nerve stimulation (PNS) suppressed PLP in P01, but was ineffective in P02. By contrast, transcutaneous electrical nerve stimulation (TENS) was effective in P02. In P03, spinal cord stimulation (SCS) was used to suppress PLP. Changes in EEG oscillatory components we analyzed using spatio-spectral decomposition (SSD) and Petrosian fractal dimension (FD). With these methods, changes EEG spatio-spectral components were found in the theta, alpha, and beta bands in all patients, with these effects being specific to each individual. These changes in EEG patterns were found for both the periods when PLP level was stationary and the periods when PLP was gradually changing after neurostimulation was turned on or off. One consistent effect was an increase in EEG fractal dimension on the side contralateral to the amputation when PLP was present, while effective stimulation resulted in a decrease in fractal dimension. Overall, our findings align with the proposed roles of brain rhythms in thalamocortical dysrhythmia, which is has been linked to neuropathic pain. The individual differences in the observed effects could be related to the specifics of treatment in each patient and the unique spectral characteristics in each of them. These findings pave way to the closed-loop systems for PLP management where neurostimulation parameters are adjusted based on EEG-derived markers.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper-limb amputees

Kleeva

Soghoyan

Biktimirov

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Peripheral Nerve Stimulation for Neuropathic Pain Management: A Narrative Review

Mao,

Lv,

Sun

et al. 2024

Pain Ther

View full text Add to dashboard Cite

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper limb amputees

Kleeva,

Soghoyan,

Biktimirov

et al. 2024

Cerebral Cortex

Self Cite

View full text Add to dashboard Cite

Phantom limb pain (PLP) is a distressing and persistent sensation that occurs after the amputation of a limb. While medication-based treatments have limitations and adverse effects, neurostimulation is a promising alternative approach whose mechanism of action needs research, including electroencephalographic (EEG) recordings for the assessment of cortical manifestation of PLP relieving effects. Here we collected and analyzed high-density EEG data in 3 patients (P01, P02, and P03). Peripheral nerve stimulation suppressed PLP in P01 but was ineffective in P02. In contrast, transcutaneous electrical nerve stimulation was effective in P02. In P03, spinal cord stimulation was used to suppress PLP. Changes in EEG oscillatory components were analyzed using spectral analysis and Petrosian fractal dimension. With these methods, changes in EEG spatio-spectral components were found in the theta, alpha, and beta bands in all patients, with these effects being specific to each individual. The changes in the EEG patterns were found for both the periods when PLP level was stationary and the periods when PLP was gradually changing after neurostimulation was turned on or off. Overall, our findings align with the proposed roles of brain rhythms in thalamocortical dysrhythmia or disruption of cortical excitation and inhibition which has been linked to neuropathic pain. The individual differences in the observed effects could be related to the specifics of each patient’s treatment and the unique spectral characteristics in each of them. These findings pave the way to the closed-loop systems for PLP management where neurostimulation parameters are adjusted based on EEG-derived markers.

show abstract

Peripheral nerve stimulation enables somatosensory feedback while suppressing phantom limb pain in transradial amputees

Cited by 8 publications

References 8 publications

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper-limb amputees

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper-limb amputees

Peripheral Nerve Stimulation for Neuropathic Pain Management: A Narrative Review

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper limb amputees

Contact Info

Product

Resources

About