Peripheral Nervous System Involvement in Lymphoproliferative Disorders

Abstract

Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable clinical, electrophysiological and pathological manifestations. In this practical review, we considered the main phenotypes of peripheral nervous system diseases associated with lymphoproliferative disorders.The area of intersection of neurological and haematological fields is of particular complexity and raises specific problems in the clinical practice of lymphoproliferative disorders. The personal crosstalk between neurologists and haematologists remains a fundamental tool for a proper diagnostic process which may lead to successful treatments in most cases.

Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review

“…24 Neurophysiological studies provide relevant information to characterize the pattern of nerve damage. As an example, demyelinating peripheral neuropathy observed in Guillain-Barré syndrome or paraneoplastic-related lymphoproliferative disorders [25][26][27] is frequently diffuse. Otherwise, mono or multifocal vasculitic pattern seen in neurolinfomatosis provokes a focal and direct nerve infiltration.…”