Peripheral neuropathy as a first sign of microscopic polyangiitis

Tejero-Delgado, M.A.; Guerrero, Ángel L; Hernández, E.; Martín-Polo, J.; Martín-Serradilla, J.I.; Gutiérrez, Fernando R.; Iglesias, Fernando Monsalve; Sánchez-Barranco, F.; Laherrán, E.

doi:10.1016/s2173-5808(11)70067-0

Cited by 1 publication

(1 citation statement)

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“…In addition, the hemorrhagic staining of macrophages on the Bronchoalveolar lavage further support the diagnosis of small vessel vasculitis. So such resolution of pulmonary manifestation of WG achieved solely with antibiotics, might indicate the direct relation between infection and WG and even stir up the question of prophylactic antibiotic treatment in patients with family history of autoimmune disease or encourage development specific vaccinations for such a population [4,[7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

A peripheral neuropathy with unusual progression in Wegener's granulomatosis

Kazzaz¹,

Massien²

2013

IJCRI

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Introduction: We present a case of Wegener's granulomatosis (WG) with unique sequence of progression into a rare presentation of peripheral neuropathy; previously there has been one similar case. However, instead of the two years lag after sinusitis development our case manifested with peripheral neuropathy in a quick fashion. Also we have observed a chronological sequence of progression from infectious process into Wegener's granulomatosis. Case Report: We present a case of a 66yearold Caucasian male previously healthy who presented initially with symptoms of sinusitis and pneumonia, which in a span of three months presented with peripheral neuropathy advancing to left foot drop. Conclusion: In Wegener's granulomatosis, the symptoms of most prominence might not necessarily be the classical presentation of upper or lower respiratory involvement but could be neurological and does not always follow the course of chronic involvement before advancing to severe neurological consequence such as foot drop. In addition, the hypothesis that infections could have contributory role in development or is a factor in Wegener's granulomatosis is observed here in the chronological sequence of events from pneumonia to manifestation of the disease and nonetheless the seroconversion of CANCA to positivity.

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