Peripheral oxytocin and vasopressin are associated with clinical symptom severity and cognitive functioning in midlife women with chronic schizophrenia

Rubin, Leah H.; Wehring, Heidi J.; Demyanovich, Haley; Carter, C. Sue; Pournajafi-Nazarloo, Hossein; Feldman, Stephanie; Earl, Amber; August, Sharon; Gold, James M.; Kelly, Deanna L.

doi:10.1016/j.schres.2017.09.041

Cited by 25 publications

(16 citation statements)

References 10 publications

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“…Among female patients, we found lower levels of AVP but not OT. This hormone profile is consistent with many (Rubin et al, 2014; Rubin et al, 2010; Rubin et al, 2015; Rubin et al, 2018), but not all (Rubin et al, 2018), of our previous studies. Furthermore, among female patients, there were some hormone-brain physiology associations that suggested a loss of hormonal modulation such as the association of AVP and ALFF in frontal cortex (superior frontal gyri), while other findings suggested increased hormonal modulation such as the association of OT and ALFF in frontal (superior frontal/middle frontal gyri) and cerebellar cortices even though OT levels were not themselves abnormal.…”

Section: Discussionsupporting

confidence: 93%

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Rubin

Li²,

Yao³

et al. 2018

Schizophrenia Research

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Background Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. Methods OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site. Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) which are believed to reflect intrinsic spontaneous neuronal activity. Results In female patients, lower OT levels were associated with lower ALFF in frontal and cerebellar cortices (p’s<0.05) and in female controls AVP levels were inversely associated with ALFF in the frontal cortex (p=0.01). In male patients, lower OT levels were associated with lower ALFF in the posterior cingulate and lower AVP levels were associated with lower ALFF in frontal cortex (p’s<0.05). In male controls, lower OT levels were associated with lower ALFF in frontal cortex and higher ALFF in the thalamus (p’s<0.05). There were some inverse ALFF-behavior associations in patients. Conclusions Alterations in peripheral hormone levels are associated with resting brain physiology in a sex-dependent manner in schizophrenia. These effects may contribute to sex differences in psychiatric symptom severity and course of illness in schizophrenia.

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Section: Discussionsupporting

confidence: 93%

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Rubin

Li²,

Yao³

et al. 2018

Schizophrenia Research

Self Cite

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“… 1 , 3 – 6 Previous studies found relationships between AVP changes and some symptoms of schizophrenia, but we did not obtain similar findings. 7 , 8 Studies on AVP levels in schizophrenia patients are limited, and our findings showed that ANP levels were not significantly lower in schizophrenia patients compared to controls. 1 , 9 Gul et al are right to note that our study had a small sample size.…”

contrasting

confidence: 50%

Posterior pituitary neurohormonal disturbances in schizophrenia and role of oxytocin in treatment – need for more short- and long-term studies

Gul¹,

Gul²,

Godil³

2018

NDT

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“…Sources of individual differences in OT and VP and the sensitivity of their receptors include gender and basic genetic differences ( 6 , 7 ). For example, some species, including humans and other socially monogamous mammals, such as prairie voles and dogs, have high levels of OT ( 8 , 9 ) and an apparent dependence on OT to allow the expression of high sociality and attention to positive social cues. The OT receptor (OTR) and V1a receptor (V1aR) also can be epigenetically tuned by experience ( 10 – 14 ), increasing the capacity of OT and VP to have complex adaptive functions.…”

Section: Introductionmentioning

confidence: 99%

The Oxytocin–Vasopressin Pathway in the Context of Love and Fear

2017

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Vasopressin (VP) and oxytocin (OT) are distinct molecules; these peptides and their receptors [OT receptor (OTR) and V1a receptor (V1aR)] also are evolved components of an integrated and adaptive system, here described as the OT–VP pathway. The more ancient peptide, VP, and the V1aRs support individual survival and play a role in defensive behaviors, including mobilization and aggression. OT and OTRs have been associated with positive social behaviors and may function as a biological metaphor for social attachment or “love.” However, complex behavioral functions, including selective sexual behaviors, social bonds, and parenting require combined activities of OT and VP. The behavioral effects of OT and VP vary depending on perceived emotional context and the history of the individual. Paradoxical or contextual actions of OT also may reflect differential interactions with the OTR and V1aR. Adding to the complexity of this pathway is the fact that OT and VP receptors are variable, across species, individuals, and brain region, and these receptors are capable of being epigenetically tuned. This variation may help to explain experience-related individual and sex differences in behaviors that are regulated by these peptides, including the capacity to form social attachments and the emotional consequences of these attachments.

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Peripheral oxytocin and vasopressin are associated with clinical symptom severity and cognitive functioning in midlife women with chronic schizophrenia

Cited by 25 publications

References 10 publications

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Posterior pituitary neurohormonal disturbances in schizophrenia and role of oxytocin in treatment – need for more short- and long-term studies

The Oxytocin–Vasopressin Pathway in the Context of Love and Fear

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Peripheral oxytocin and vasopressin are associated with clinical symptom severity and cognitive functioning in midlife women with chronic schizophrenia

Cited by 25 publications

References 10 publications

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Posterior pituitary neurohormonal disturbances in schizophrenia and role of oxytocin in treatment &ndash; need for more short- and long-term studies

The Oxytocin–Vasopressin Pathway in the Context of Love and Fear

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Posterior pituitary neurohormonal disturbances in schizophrenia and role of oxytocin in treatment – need for more short- and long-term studies