Peripheral parameters of oxidative stress in Graves’ disease: the effects of methimazole and 131 iodine treatments

Abalovich, Marcos; Llesuy, Susana; Gutierrez, Stanley Juan Chávez; Repetto, Marisa G.

doi:10.1046/j.1365-2265.2003.01850.x

Cited by 83 publications

(80 citation statements)

References 38 publications

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“…In addition, the low success rate of radioiodine therapy under simultaneous carbimazole therapy in spite of comparable radioiodine uptake strongly argues against a radioiodine uptake-mediated detrimental mechanism of carbimazole. In this context, radioprotection by the inhibition of peroxidase-catalysed synthesis of oxygen free radicals, which mediate the cell damage in radioiodine therapy [10,11], appears to be a more likely mechanism.…”

Section: Discussionmentioning

confidence: 99%

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Outcome of radioiodine therapy without, on or 3 days off carbimazole: a prospective interventional three-group comparison

Walter

Christ‐Crain

Schindler

et al. 2006

Eur J Nucl Med Mol Imaging

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Abstract. Purpose: Carbimazole ameliorates hyperthyroidism but reduces radioiodine uptake and adversely affects the outcome of simultaneous radioiodine therapy. We explored whether withdrawal of carbimazole for 3 days can restore the outcome of radioiodine treatment without concurrent exacerbation of hyperthyroidism. By generating three groups with comparable radioiodine uptake, we also investigated whether the effect of carbimazole depends on the radioiodine uptake. Methods: Stratified by a radioiodine uptake >30%, 227 consecutive adult patients were prospectively assigned to radioiodine therapy (target dose 200 Gy) without, on or 3 days off carbimazole. Patients were clinically (CrooksWayne score) and biochemically (T 3 , fT 4 , TSH) followed up after 3, 6 and 12 months. Primary endpoint was outcome 12 months after radioiodine therapy. Results: A total of 207 patients completed follow-up (toxic nodular goitre, n=117; Graves' disease, n=90). The overall success rate was 71.5%. Patients without and 3 days off carbimazole had similar biochemical (81.4% and 83.3%, respectively; p=0.82) and clinical outcomes [median (range) Crooks-Wayne score 0 (0-16) and 1 (0-10), respectively; p=0.73], which were both higher than in patients on carbimazole [42.6%, p<0.001; Crooks-Wayne score 3 (0-30), p<0.03]. Time to achieve cure was delayed on carbimazole. No changes in thyroid hormone levels occurred after 3 days' discontinuation of carbimazole. Logistic regression revealed that all observed cure rates were independent of entity, sex, age, thyroid volume, radioiodine uptake, radioiodine half-life, fT 4 , T 3 and TSH. Conclusion: Patients under carbimazole treatment can be referred for radioiodine therapy after withdrawal of carbimazole for only 3 days. Three days of carbimazole withdrawal is long enough to restore the success of radioiodine therapy and short enough to avoid the risk of exacerbation of hyperthyroidism.

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Section: Discussionmentioning

confidence: 99%

“…Carbimazole decreases the peroxidase-catalysed synthesis of oxygen free radicals, which mediate the cell damage produced by radioiodine [10,11]. On the other hand, carbimazole reduces the cellular radioiodine uptake [3,5], which has also been thought to decrease the success of radioiodine therapy [12,13].…”

Section: Introductionmentioning

confidence: 99%

Outcome of radioiodine therapy without, on or 3 days off carbimazole: a prospective interventional three-group comparison

Walter

Christ‐Crain

Schindler

et al. 2006

Eur J Nucl Med Mol Imaging

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“…The selected drug directly inhibits the synthesis of thyroid hormones by interfering with iodine incorporation into tyrosyl residues of thyroglobulin, secondary to interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme. The primary influence on hypothalamus/hypophysis axis was not revealed [1,27].…”

Section: Discussionmentioning

confidence: 99%

“…The regulation of antioxidative defence is multifactorial. Many studies have indicated connections of iodothyronine hormones with oxidative stress [1,4,7,16,20]. NADPH 2 cytochrome P-450 reductase (P-450R), the main enzyme responsible for the doxorubicin-dependent free radical generation, is strictly regulated by triiodothyronine (T3) [8,17] and markedly decreased level of this enzyme (30-50%) was observed in heart of rats treated with methimazole [25,28].…”

Section: Introductionmentioning

confidence: 99%

Effect of iodothyronine hormone status on doxorubicin related cardiotoxicity

Dudka¹,

Mańdziuk²,

Madej-Czerwonka³

et al. 2013

Folia Morphol

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“…Подтверждением этого является обнаружение досто верно более высоких концентраций мочевого малон диальдегида (маркер оксидативного стресса) у паци ентов с БГ по сравнению с группой контроля [35]. К настоящему моменту имеются данные о том, что прием тиреостатиков (тиамазол или пропицил) у па циентов с БГ приводит к восстановлению окисли тельного баланса в тиреоцитах [1,68].…”

Section: селен и болезнь грейвсаunclassified