Peripheral Primitive Neuroectodermal Tumor of the Chest Wall of a 69-year-old Man

Takagi-Takahashi, Yoko; Shijubo, Noriharu; Yamada, Gen; Saitoh, Eri; Sawada, Kyoko; Ohnishi, Tetsuro; Itoh, Takayuki; Saikai, Toyohiro; Ikeda, Tatsuru; Kimura, Sachiko; Takahashi, Hiroki; Abe, Shosaku

doi:10.2169/internalmedicine.43.578

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…Several cases of PNET have been found to be positive for NSE [23] but negative for ProGRP in both serum and tumor cells [24]. However, one case with elevated NSE and ProGRP has been described [25], and these tumor markers may be useful for identifying PNET.…”

Section: Discussionmentioning

confidence: 99%

Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin

et al. 2010

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A primitive neuroectodermal tumor (PNET) is a small round cell tumor that arises from the nerve crest. This tumor usually occurs in the central nervous system or soft tissue, but it can occur in the kidney in rare cases. Herein we report a case with severe multiple liver metastases after surgery for right renal PNET. The patient was a 21-year-old man with a chief complaint of right abdominal pain. Hemorrhage in a right renal malignant tumor was diagnosed, and radical nephrectomy was performed. Histopathology showed bare nuclear round atypical cells with a scarce cytoplasm proliferating like a seat and nest. Some of the cells formed a rosette structure and the tumor cells were positive for CD99, leading to diagnosis of PNET. Severe multiple liver metastases occurred 6 months after surgery, and six courses of chemotherapy with ifosfamide, etoposide and doxorubicin were performed. After this treatment, residual tumor was removed, but the tumor cells were absent histologically.

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Section: Discussionmentioning

confidence: 99%

Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin

et al. 2010

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“…Positive immunohistochemical staining for neurofilament protein, S-100, synaptophysin, cytokeratin, vimentine, Leu-7 and epithelial membrane antigen facilitate the diagnosis, but are not pathognomic. PNET often stain positively with antibodies for the MIC II gene product, but this gene product is not entirely specific (3,4,9,10).…”

Section: Discussionmentioning

confidence: 99%

Primary Primitive Neuro-ectodermal Tumour of the Lung

Verfaillie

Hoorens²,

Lamote³

2009

Acta Chirurgica Belgica

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A case of intrapulmonary primitive neuro-ectodermal tumour (PNET) without thoracic wall involvement is presented in a 33-year-old man. PNET of the thoracopulmonary region, also called Askin tumour, is a rare undifferentiated sarcoma usually involving the thoracic wall. Primary intrapulmonary PNET without parietal pleura or thoracic wall involvement is very rare. The correlation between anatomo-pathological aspects and clinical imaging is emphasized, which is discussed in the light of the most recent literature.

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“…It is also possible that, in the past, lung cancers have been incorrectly diagnosed in adults with a PNET [7].…”

Section: Task 4 How Would You Treat This Patient? Discussionmentioning

confidence: 99%

Too old to have a tumour of the young?

Craig

Ohri

Benson

et al. 2007

Breathe

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A 38-year-old Caucasian male presented to hospital with a 2-week history of progressive exertional dyspnoea and intermittent left pleuritic chest pain, which was not relieved by analgesia.The patient denied cough, sputum production, haemoptysis, wheeze, weight loss, vomiting, altered bowel habits, urinary symptoms, recent trauma, recent travel and immobility. He had a history of hypertension, allergic rhinitis, obesity and chronic bilateral leg oedema.He had a 25 pack-year smoking history, drank minimal alcohol and was taking atenolol and aspirin. There was no family history. Examination and investigationsExamination revealed that the patient was obese, febrile (37.7°C) and hypoxaemic (pulse oximetry of 89% on room air), with a respiratory rate of 25 breaths per min, blood pressure of 95/65 mmHg and a pulse of 120 beats per min (sinus tachycardia).The patient had clinical signs consistent with a left pleural effusion, which was confirmed by chest radiography. There was no wheeze or crepitations, and heart sounds were normal. His jugular venous pressure was not raised and there was no palpable lymphadenopathy. Abdominal examination was unremarkable and the limbs did not demonstrate signs of deep vein thrombosis.Pleural aspiration revealed bloodstained fluid (pH 7.19) and negative cytology and culture. Bronchoscopy was not undertaken owing to the hypoxaemia and radiological findings. As the patient had swinging fevers, an infective cause was initially suspected and he was therefore commenced on broad spectrum intravenous antibiotics.A contrast-enhanced computed tomography (CT) scan of the chest revealed a large left pleural effusion with no evidence of pulmonary embolus, broncho-stenosing lesion or empyema.Owing to persistent fever and pain, a second CT scan was performed after partial pleural drainage. A representative slice is shown in figure 1. A CT-guided biopsy was also performed (figure 2).

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Peripheral Primitive Neuroectodermal Tumor of the Chest Wall of a 69-year-old Man

Cited by 9 publications

References 15 publications

Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin

Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin

Primary Primitive Neuro-ectodermal Tumour of the Lung

Too old to have a tumour of the young?

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