Peripheral progesterone concentrations in the luteal-phase ewe: effects of a β-adrenergic receptor antagonist and two β2-adrenergic agonists

Wheeler, A. G.; Lean, Jenny M.; Walker, Matthew T.

doi:10.1677/joe.0.1160137

Cited by 15 publications

(4 citation statements)

References 19 publications

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“…Following antioxidant administration, the murine ovarian transcriptome reflected an environment with enhanced cell survival and β-adrenergic signaling, decreased apoptotic signaling proinflammatory pathways, and altered antioxidant signaling compared to control aged mice. Upregulated β-adrenergic signaling may contribute to improved ovarian function through changes in follicular development and hormone secretion [37][38][39], particularly since ovarian sympathetic nerve activity may decline with ovarian aging [40]. The anti-inflammatory effects of antioxidant treatment are consistent with previous reports [41].…”

Section: Discussionsupporting

confidence: 81%

Antioxidant Intervention Attenuates Aging-Related Changes in the Murine Ovary and Oocyte

Katz‐Jaffe

Lane

Parks

et al. 2020

Life

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Advanced maternal age (AMA) is associated with reduced fertility due in part to diminished ovarian follicle quantity, inferior oocyte quality, chromosome aneuploidy, and lower implantation rates. Ovarian aging is accompanied by increased oxidative stress and blunted antioxidant signaling, such that antioxidant intervention could improve reproductive potential. The first aim of this study was to determine the molecular effects of antioxidant intervention in the ovaries and oocytes of aged mice, utilizing a supplement containing only naturally occurring açaí (Euterpe oleracea) with an oxygen radical absorbance capacity of 208,628 μmol Trolox equivalent (TE)/100 g indicating high antioxidant activity. Nine month old female CF-1 mice were administered 80 mg/day antioxidants (n = 12) or standard diet (n = 12) for 12 weeks. In the ovary, antioxidant treatment upregulated β-adrenergic signaling, downregulated apoptosis and proinflammatory signaling, and variably affected cell growth and antioxidant pathways (p < 0.05). Exogenous antioxidants also increased the oocyte expression of antioxidant genes GPX1, SOD2, and GSR (p < 0.05). A feasibility analysis was then conducted on female AMA infertility patients as a proof-of-principle investigation. Patients (n = 121; <45 years old) consented to receiving 600 mg antioxidants three times daily for ≥8 weeks preceding infertility treatment. Preliminary results indicate promising outcomes for AMA patients, warranting further investigation.

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Section: Discussionsupporting

confidence: 81%

Antioxidant Intervention Attenuates Aging-Related Changes in the Murine Ovary and Oocyte

Katz‐Jaffe

Lane

Parks

et al. 2020

Life

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“…Further support for the role of catecholamines in luteal function has been demonstrated in vivo by Weiss, Dail & Ratner (1982) who found that electrical stimulation of the superior ovarian nerve enhanced progesterone production in the rat, and also by Burden & Lawrence (1977) who reported that denervation or chemical sympathectomy decreased 3ß-hydroxysteroid dehydrogenase activity in corpora lutea of pregnant rats. Additionally, administration of ß-adrenergic agonists or antagonists to luteal phase ewes modulates progesterone secretion (Wheeler, Lean & Walker, 1988). In our study, there was no direct relationship between noradrenaline or dopa¬ mine and progesterone concentrations in individual corpora lutea.…”

Section: Discussioncontrasting

confidence: 66%

Regional differences in catecholamine concentrations in bovine ovaries analysed by high-performance liquid chromatography

Denning-Kendall

Wathes²

1991

Journal of Endocrinology

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Bovine corpora lutea and ovarian stroma were analysed by high-performance liquid chromatography for catecholamine content. High concentrations (up to 102 nmol/g wet weight) were found in both 'central' stroma, containing many blood vessels, and 'peripheral' stroma. Central stroma contained noradrenaline and some dopamine, whereas peripheral stroma contained a higher proportion of dopamine and also significant amounts of 3,4-dihydroxyphenylacetic acid (DOPAC). Occasional samples of stroma had very high amounts of dopamine, suggesting that it is stored in specific regions. Corpora lutea, although devoid of direct innervation, contained dopamine (up to 5.3 nmol/g) and noradrenaline (up to 1.2 nmol/g). The average dopamine:noradrenaline molar ratio was 1.19:1 and the concentrations of dopamine and noradrenaline were highly correlated (P less than 0.002). The concentration of dopamine was significantly higher in the early luteal phase of the oestrous cycle than during the rest of the cycle or in pregnancy. The levels of noradrenaline and dopamine present in corpora lutea are sufficient to modulate the production of both oxytocin and progesterone by luteal cells in vitro.

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“…Studies in vitro with different ovarian cells revealed that catecholamines act on target cells via 8-receptors. Thls was also shown in vivo (Wheeler et al 1988;Skarzynski and Kotwica 1993) and by 38-HSD activation (Jones et al 1983) to stimulate steroidogenesis. LH is the luteotrophic hormone in ruminants (Baird 1992), but NA gtven in conscious heifers did not affect LH concentrations .…”

mentioning

confidence: 91%

Effect of Catecholamines on the Secretory Function of the Bovine Corpus Luteum

Kotwica

Skanynski

Bogacki

1995

Reprod Domestic Animals

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ContentsAdrenergic innervation of the ovary is crucial for the corpus luteum (CL) secretory function in many species. Noradrenergic stimulation of the ovary or noradrenaline (NA) treatment causes a prompt increase in progesterone and ovarian oxytocin (OT) secretion during the entire luteal phase. Ths effect is medated via luteal cell 8-recep tors. Their amount correlates with peripheral progesterone concentrations on days 4, 8 and 12 of the oestrous cycle. NA also stimulates progesterone and OT synthesis by activating 38-hydroxysteroid dehydrogenase (38-HSD) and peptidyl glycine-a-amidating monooxygenase (PGA), respectively, withn the luteal cell. On the other hand, ovarian denervation in the rat and ewe causes many morphe logical and functional changes, i.e. a decrease of luteal steroidogenic activity, an increase in the number of B-receptors on luteal cells, disruption of cyclicity, delay of follicular development, etc. Furthermore, a brief blockade of ovarian 8-receptors in mid cycle in cattle decreases progesterone secretion by up to 40%. It was also dmovered that NA can be synthesised within the CL from dopamine @A) and moreover, NA does appear to activate tyrosine hydroxylase converting tyrosine to DOPA, which is transformed further to dopamine. It is suggested that (1) constant 8-stimulation of the CL ensures basal secretion of progesterone, whereas short-term noradrenergtc system activation prevents and even supports CL function; (2) activation of the noradrenergic system and its concomitant influence on ovarian and peripheral vasculature, lipolysis and luteal cell enzyme activity causes a prompt response of the CL to brief stressful situations which could impair its function and (3) NA affects its own synthesis within the CL. Ovarian innervationThe extrinsic autonomic nerves reach the ovary via the nerve in the suspensory ligament (superior ovarian nerve) innervating predominantly the endocrine component, and the ovarian plexus which innervates mamly the ovarian vasculature (Lawrence and Burden 1980). Ovarian NA content which reflects ovarian innervation increased in rats (Ben-Jonatan et al. 1984) during sexual maturation and declines during agmg (Ferrante et a]. 1990). NA and DA, which is a NA precursor, were found in bovine CL and ovarian stroma, and DA concentrations were much hgher in the early luteal phase than during the rest of the cycle or pregnancy penning- Kendall et al. 1991). In addition, follicular differentiation in newborn rats depends on direct neurogenic influence when ovaries are insensitive to gonadotrophins (Malamed et a]. 1992). The increase in ovarian NA and DA content in cyclic rats with lesions in the amygdaloid complex suggests that the amygdaloid catecholaminergtc system exerts an inhibitory ef€ect on ovarian catecholamines (Leret et al. 1992). Likewise, in rats with posterior hypothalamic lesions inflicted on the day of birth, NA Concentrations at puberty were markedly higher than in intact controls (Ivanisevic-Mdovanovic et al. 1993). Thus, the peripheral noradrenergic s...

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Peripheral progesterone concentrations in the luteal-phase ewe: effects of a β-adrenergic receptor antagonist and two β2-adrenergic agonists

Cited by 15 publications

References 19 publications

Antioxidant Intervention Attenuates Aging-Related Changes in the Murine Ovary and Oocyte

Antioxidant Intervention Attenuates Aging-Related Changes in the Murine Ovary and Oocyte

Regional differences in catecholamine concentrations in bovine ovaries analysed by high-performance liquid chromatography

Effect of Catecholamines on the Secretory Function of the Bovine Corpus Luteum

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