Peripheral prostaglandin metabolite levels in women undergoing therapeutic abortions in the first trimester with and without treatment with prostaglandin synthetase inhibitor

Wolfe, Walter M.; Rao, Ch.V.; McCracken, E.; Demers, Laurence M.

doi:10.1016/0262-1746(87)90047-3

Cited by 2 publications

(1 citation statement)

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“…Few studies have been performed to measure prostaglandin metabolite levels during termination. Wolfe et al (26) demonstrated an increase in PGFM levels immediately after surgical termination of pregnancy; a similar increase was not detected in PGEM levels. The increase in PGFM may have been secondary to mechanical stimulation which occurs during the termination process (27).…”

Section: Discussionmentioning

confidence: 91%

The Effect of the Anti‐Progestin Mifepristone (RU 486) on Plasma Prostaglandin Metabolite levels in Early Pregnancy and its Influence on Pregnancy Termination

Hill

Bernal

Ferguson

et al. 1990

Acta Obstet Gynecol Scand

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The effect of a single dose of RU 486 (600mg) on prostaglandin metabolite levels has been studied over a 48 h period in 20 women undergoing medical termination of early pregnancy. The results were compared with controls of similar gestation who were treated surgically. The mean (SD) PGEM levels at 0 and 48 h in the RU 486 group were 13.7 (2.7) and 13.2 (2.2) pg/ml respectively, which was not significantly different from the values of 11.7 (1.1) and 11.3 (0.4) pg/ml measured in the control patients. Similarly the mean (SD) PGFM values of 22.3 (14.7) and 17.0 (7.2) pg/ml at 0 and 48 h were not significantly different from the corresponding control values of 21.9 (13.8) and 23.8 (7.2) pg/ml. In 10 of the study patients, there were no significant changes in PGEM and PGFM concentrations prior to and at 4, 24 and 48 h after RU 486 administration. Although all pregnancies were successfully terminated with the combination of RU 486 and subsequently a vaginal pessary containing PGE1, no stimulation of prostaglandin production could be demonstrated.

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Section: Discussionmentioning

confidence: 91%