Peripheral pulmonary nodules: Relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF expression

Ma, Shuhua; Le, Hongbo; Jia, Bin; Wang, Zhaoxin; Xiao, Zhuangwei; Cheng, Xiaoling; Mei, Wei; Wu, Min; Hu, Zhiguo; Li, Yuguang

doi:10.1186/1471-2407-8-186

Cited by 78 publications

(57 citation statements)

References 22 publications

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“…In fact, several studies have shown that the enhancement of dynamic CT in lung cancer positively correlates with MVD [7][8][9] . In our study, BF of the lesions was positively correlated with MVD.…”

Section: Discussionmentioning

confidence: 99%

The use of CT perfusion to determine microvessel density in lung cancer: Comparison with FDG-PET and pathology

Xing

Cai

Zhao

et al. 2011

Chin. J. Cancer Res.

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Section: Discussionmentioning

confidence: 99%

The use of CT perfusion to determine microvessel density in lung cancer: Comparison with FDG-PET and pathology

Xing

Cai

Zhao

et al. 2011

Chin. J. Cancer Res.

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“…All patients underwent baseline CT-p of the primary lung cancer within 1062 (6)(7)(8)(9)(10)(11)(12) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Functional imaging has been claimed to provide more relevant information on tissue viability during treatment monitoring than the standard therapeutic response assessment (RECIST) based on tumour size changes [6][7][8], which is currently used. Among other imaging modalities, CT perfusion (CT-p) recently experienced a progressive increase in interest and acceptance in the radiological community for oncological applications [9][10][11][12][13], including both the diagnostic process and follow-up of lung cancer [14][15][16]. Substantial differences between treatment response to conventional and anti-angiogenic drugs assessed by RECIST criteria and CT-p in patients with lung adenocarcinoma have been evidenced [17].…”

mentioning

confidence: 99%

Whole-tumour CT-perfusion of unresectable lung cancer for the monitoring of anti-angiogenetic chemotherapy effects

Fraioli

Anzidei

Serra

et al. 2013

BJR

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Objective: To determine whether CT-perfusion (CT-p) can be used to evaluate the effects of chemotherapy and anti-angiogenic treatment in patients with non-small-cell lung carcinoma (NSCLC) and whether CT-p and standard therapeutic response assessment (RECIST) data obtained before and after therapy correlate. Methods: 55 patients with unresectable NSCLC underwent CT-p before the beginning of therapy and 50 of them repeated CT-p 90 days after it. Therapeutic protocol included platinum-based doublets plus bevacizumab for non-squamous carcinoma and platinum-based doublets for squamous carcinoma. RECIST measurements and calculations of blood flow (BF), blood volume (BV), time to peak (TTP) and permeability surface (PS) were performed, and baseline and post-treatment measurements were tested for statistically significant differences. Baseline and follow-up perfusion parameters were also compared based on histopathological subclassification (2004 World Health Organization Classification of Tumours) and therapy response assessed by RECIST. Results: Tumour histology was consistent with large cell carcinoma in 14/50 (28%) cases, adenocarcinoma in 22/50 (44%) cases and squamous cell carcinoma in the remaining 14/50 (28%) cases. BF and PS differences for all tumours between baseline and post-therapy measurements were significant (p50.001); no significant changes were found for BV (p50.3) and TTP (p50.1). The highest increase of BV was demonstrated in adenocarcinoma (5.2634.1%), whereas the highest increase of TTP was shown in large cell carcinoma (6.9622.4%), and the highest decrease of PS was shown in squamous cell carcinoma (221.5618.5%). A significant difference between the three histological subtypes was demonstrated only for BV (p,0.007). On the basis of RECIST criteria, 8 (16%) patients were classified as partial response (PR), 2 (4%) as progressive disease (PD) and the remaining 40 (80%) as stable disease (SD). Among PR, a decrease of both BF (1869.6%) and BV (12.669.2%) were observed; TTP increased in 3 (37.5%) cases, and PS decreased in 6 (75%) cases. SD patients showed an increase of BF, BV, TTP and PS in 6

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“…Thus, the analysis of the microcirculation by perfusion CT can be useful in the clinical situation including evaluation of treatment response. Perfusion CT can be used for detection of tumor angiogenesis and in assessing response to antiangiogenic treatment for various cancers [27,28]. Regarding liver imaging, the greatest impact of perfusion CT has been shown in the assessment of patients with HCC, especially that of tumor response to antiangiogenic drugs, such as sorafenib (Nexavar, Bayer Schering Pharma AG, Berlin, Germany) [29,30].…”

Section: Ct Imagingmentioning

confidence: 99%

Ultrasonography, Computed Tomography and Magnetic Resonance Imaging of Hepatocellular Carcinoma: Toward Improved Treatment Decisions

et al. 2011

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Detection, characterization, staging, and treatment monitoring are major roles in imaging diagnosis in liver cancers. Contrast-enhanced ultrasonography (CEUS) using microbubble contrast agents has expanded the role of US in the detection and diagnosis of liver nodules in patients at high risk of hepatocellular carcinoma (HCC). CEUS provides an accurate differentiation between benign and malignant liver nodules, which is critical for adequate management of HCC and is also useful for guidance of percutaneous local therapy of HCC and postprocedure monitoring of the therapeutic response. The technology of multidetector-row computed tomography (MDCT) has increased spatial and temporal resolutions of computed tomography (CT). It has made possible a more precise evaluation of the hemodynamics of liver tumor, and the diagnostic accuracy of dynamic MDCT has improved. Perfusion CT can measure tissue perfusion parameters quantitatively and can assess segmental hepatic function. Dynamic MDCT with high spatial and temporal resolution enables us to reconstruct 3- and 4-dimensional imaging, which is very useful for pretreatment evaluation. Dual-energy CT makes possible the differentiation of materials and tissues in images obtained based on the differences in iodine and water densities. Monochromatic images, which can be reconstructed by dual-energy CT data, provide some improvement in contrast and show a higher contrast-to-noise ratio for hypervascular HCCs. Dynamic magnetic resonance imaging with fast imaging sequence of 3-dimensional Fourier transformation T₁-weighted gradient echo and nonspecific contrast medium can show high detection sensitivity of hypervascular HCC. However, the hepatic tissue-specific contrast medium, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid, has become an essential contrast medium for liver imaging because of its higher diagnostic ability. It may replace CT during hepatic arteriography and during arterioportography.

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Peripheral pulmonary nodules: Relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF expression

Cited by 78 publications

References 22 publications

The use of CT perfusion to determine microvessel density in lung cancer: Comparison with FDG-PET and pathology

The use of CT perfusion to determine microvessel density in lung cancer: Comparison with FDG-PET and pathology

Whole-tumour CT-perfusion of unresectable lung cancer for the monitoring of anti-angiogenetic chemotherapy effects

Ultrasonography, Computed Tomography and Magnetic Resonance Imaging of Hepatocellular Carcinoma: Toward Improved Treatment Decisions

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