Peripheral retinal ablation for threshold retinopathy of prematurity in preterm infants

Andersen, Chad; Phelps, Dale L.

doi:10.1002/14651858.cd001693

Cited by 20 publications

(11 citation statements)

References 38 publications

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“…New lesions could appear in initially healthy areas, which stresses the need for a strict surveillance after initial treatment. The parameters and efficiency of laser treatment in IP are mainly based on the large existing studies and current recommendations on retinopathy of prematurity (ROP) [11]. Intravitreal injections of antivascular endothelial growth factor (VEGF) have recently been proposed as an alternative treatment in IP retinopathy, either as an adjunct therapy [12,13], or as a first line treatment [14].…”

Section: Discussionmentioning

confidence: 99%

Early management of sight threatening retinopathy in incontinentia pigmenti

Michel

Reynaud

Daruich

et al. 2020

Orphanet J Rare Dis

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Background: Early blindness secondary to incurable retinal detachment is one of the main complications of incontinentia pigmenti (IP). The efficiency of ophthalmological management for preventing such evolution has not been proven. The objective of this retrospective study was to report a screening and treatment strategy of the vascular retinopathy in newborns and infants with IP. Results: All files of patients diagnosed with IP within the two first months of life in a single tertiary referral center, between 2010 and 2015, were retrospectively included. The minimum follow-up duration was three years. Patients had undergone systematic indirect ophthalmoscopy examination, looking for signs of peripheric retinal vasculopathy, according to a standardized schedule: at diagnosis, at age 1, 2, 3, 6, 9, 12, 18 and 24 months, and then once a year. Urgent laser therapy was performed under anesthesia in case of signs of retinal ischemia. Nineteen children files (17 girls) were studied. Median age at IP diagnosis was 1 day [0-44]; median age at first retinal evaluation was 25 days. Retinal manifestations occurred in 7 patients (n = 10/38 eyes, 26.3%); they were diagnosed at median age 19 days [3-59]. These patients underwent one or two ablative session per eye (mean 1.7, median 2), under general anaesthesia. No retinal detachment or fold occurred during the follow-up (median 6 years [3-9.8]). Conclusion: Ocular screening should be performed in all cases of IP as soon as possible after diagnosis. A strict ophthalmological monitoring and prophylactic treatment of retinal vasculopathy can efficiently prevent the early blinding complications of the disease.

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Section: Discussionmentioning

confidence: 99%

Early management of sight threatening retinopathy in incontinentia pigmenti

Michel

Reynaud

Daruich

et al. 2020

Orphanet J Rare Dis

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“…The ®rst report of retinal tears treated by freezing came from Bietti 30 in 1933, and when Bellowes reviewed cryotherapy of ocular diseases in 1966 he included cryoextraction of cataracts and treatments for glaucoma and tumours 30 . Cryosurgery still has an important place in modern ophthalmological practice, particularly for eyelash ablation in trichiasis 31 , treatment of retinopathy of prematurity 32 and retinal detachment.…”

Section: The Wider Application Of Cryosurgerymentioning

confidence: 99%

The History of Cryosurgery

Cooper¹,

Dawber²

2001

J R Soc Med

116

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“…[ 2 ] Current treatments for severe ROP including laser and anti-VEGF agents are helpful in decreasing the risk of blindness. Nevertheless, vision loss [ 51 , 52 ], reduced visual fields [ 53 , 54 ], persistent vascularization defects with risks for late complications [ 55 – 60 ] and concerns for potential systemic side effects [ 61 – 65 ] remain significant problems, highlighting the need to develop better predictors for infants at risk for more severe ROP to aid in prioritizing treatment to reduce lifelong visual impairment. Our studies suggest that screening for rare polymorphisms in FEVR genes could be a worthwhile endeavour to determine their predictive value for the development of more severe ROP.…”

Section: Discussionmentioning

confidence: 99%

Fzd4 Haploinsufficiency Delays Retinal Revascularization in the Mouse Model of Oxygen Induced Retinopathy

et al. 2016

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Mutations in genes that code for components of the Norrin-FZD4 ligand-receptor complex cause the inherited childhood blinding disorder familial exudative vitreoretinopathy (FEVR). Statistical evidence from studies of patients at risk for the acquired disease retinopathy of prematurity (ROP) suggest that rare polymorphisms in these same genes increase the risk of developing severe ROP, implying that decreased Norrin-FZD4 activity predisposes patients to more severe ROP. To test this hypothesis, we measured the development and recovery of retinopathy in wild type and Fzd4 heterozygous mice in the absence or presence of ocular ischemic retinopathy (OIR) treatment. Avascular and total retinal vascular areas and patterning were determined, and vessel number and caliber were quantified. In room air, there was a small delay in retinal vascularization in Fzd4 heterozygous mice that resolved as mice reached maturity suggestive of a slight defect in retinal vascular development. Subsequent to OIR treatment there was no difference between wild type and Fzd4 heterozygous mice in the vaso-obliterated area following exposure to high oxygen. Importantly, after return of Fzd4 heterozygous mice to room air subsequent to OIR treatment, there was a substantial delay in retinal revascularization of the avascular area surrounding the optic nerve, as well as delayed vascularization toward the periphery of the retina. Our study demonstrates that a small decrease in Norrin-Fzd4 dependent retinal vascular development lengthens the period during which complications from OIR could occur.

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Peripheral retinal ablation for threshold retinopathy of prematurity in preterm infants

Cited by 20 publications

References 38 publications

Early management of sight threatening retinopathy in incontinentia pigmenti

Early management of sight threatening retinopathy in incontinentia pigmenti

The History of Cryosurgery

Fzd4 Haploinsufficiency Delays Retinal Revascularization in the Mouse Model of Oxygen Induced Retinopathy

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