Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report

Aquino, Gabriella; Franco, Renato; Ronconi, Fioravante; Anniciello, Annamaria; Russo, Luigi; Chiara, Annarosaria De; Panico, Luigi

doi:10.1186/1746-1596-7-79

Cited by 12 publications

(9 citation statements)

References 35 publications

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“…It can activate CDK4 or CDK6 to phosphosphorylate a series of key substrates, such as protein Rb, in that case, the transcription factors will be released to promote synthesis of DNA and accelerate the cells proliferation [ 17 ]. Thus it is an essential sensor and activator of cell cycle initiation and progression; Cyclin D1 amplification and gain copies with consequent protein over-expression have been frequently described in multiple myeloma, T cutaneous lymphomas and in solid cancer [ 18 ], such as oral squamous cell carcinoma, lung cancer, melanoma, breast cancer [ 19 , 20 ]. A recent study has shown that strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

CyclinD1, a prominent prognostic marker for endometrial diseases

Liang

Wang

et al. 2013

Diagn Pathol

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PurposeAlteration of CyclinD1 was suggested to relate with development of endometrial carcinogenesis before, however CyclinD1 expression is not well defined in endometrial hyperplasia lesions. We checked the relationship between its expression and clinic-pathological variables of endometrial lesions to explore the possibility for CyclinD1 as a potential diagnostic and prognostic marker.MethodsCyclin D1 immunohistochemical analysis (IHC) was used to evaluate 201 fixed, paraffin-embedded endometrial samples which included simple hyperplasia (n = 27), atypical complex hyperplasia (ACH) (n = 41), endometrioid carcinoma (n = 103), endometrial serous carcinoma (ESC) (n = 21) and clear cell carcinoma (CCC) (n = 9). A breast cancer with known CyclinD1 expression was selected as a positive control in each immunohistochemistry run. We also performed follow-up study to estimate patients’ prognosis.ResultsCyclinD1 was significantly overexpressed in atypical complex hyperplasia (ACH), endometrioid carcinoma and clear cell carcinoma (CCC). The positive signaling of CyclinD1 was showed less than 40% in simple hyperplasia and endometrial serous carcinoma (ESC). The high expression of CyclinD1 was observed in metastasis carcinoma group more significantly than non-metastasis carcinoma group. Kaplan Meier analysis demonstrated that patients with high CyclinD1 expression had an obviously poor prognosis than patients without CyclinD1 staining (p < 0.05). Moreover, according to multivariate Cox regression analysis, CyclinD1 expression, as crucial as metastasis, was a risk marker for overall survival rate.ConclusionCyclinD1 exhibited a promising potential to predict the prognosis of patients with endometrial carcinoma. However, the statistical analysis demonstrated that CyclinD1 exhibited a poor ability to differentiate neoplastic lesions from non-neoplastic lesions; thus, the application of CyclinD1 only is not so credible for differentiation between benign and malignant lesions.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1871063048950173.

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Section: Discussionmentioning

confidence: 99%

CyclinD1, a prominent prognostic marker for endometrial diseases

Liang

Wang

et al. 2013

Diagn Pathol

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“…The final diagnosis in this case also underlined this point. In addition, as same as other T-lymphomas occurred in uncommon sites [12-16], the gastric EATL also exhibits the genetic disorder which will be helpful to distinguish from reactive process.…”

Section: Discussionmentioning

confidence: 99%

A case of enteropathy-associated T-cell lymphoma (Type I) arising in stomach without refractory celiac disease

et al. 2012

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Enteropathy-associated T-cell lymphoma (EATL) is a rare peripheral T-cell lymphoma which was classified into 2 types based on histology. EATL is often, but not always, associated with celiac disease. EATL type I is a large cell lymphoma which is more common in frequency and highly associated with celiac disease compared with type II. Jejunum and ileum are the common sites, although EATL can rarely occur in the duodenum, stomach and colon or outside the gastrointestinal tract. We herein presented one case of gastric EATL, which happened in a 73-year-old Chinese male patient. Histologically, the tumor was composed of polymorphic (pleomorphic, anaplastic, immunoblastic) lymphoid cells and numerous inflammatory cells, including histiocytes, neutrophils and eosnophils in the background. The pleomorphic lymphoid cells were diffuse and strongly positive for CD3 and partially positive for CD30, while negative for CD4, CD5, CD8 or CD56. The gastric EATL should be distinguished from other gastric lesions, such as peptic ulcer, poorly-differentiated adenocarcinoma and other types of lymphoma.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1174320824810970

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“…Meanwhile, morphologically, middle to large-sized neoplastic cells with atypia and mitosis can be detected in T cell lymphoma and ANKL. However, as previously mentioned, the characteristic T-cell makers, rearranged TCR gene, and have no relation to EBV infection are distinguishing features [14,15]. …”

Section: Discussionmentioning

confidence: 99%

Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature

et al. 2013

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Aggressive natural killer cell leukemia/lymphoma (ANKL) is a rare aggressive form of NK-cell neoplasm. We report an uncommon case of 36-year-old male who showed jaundice and spontaneous splenic rupture. The diagnosis was established by the biopsy of liver and spleen. The monomorphous medium-size neoplastic cells infiltrated into portal areas and sinus of liver as well as the cords and sinus of the spleen. Necrosis, mitotic figures and significant apoptosis could be seen easily. These neoplastic cells demonstrated a typical immunophenotype of CD3ε+, CD56+, CD16+, Granzyme B+, TIA-1+. T-cell receptor γ (TCR-γ) gene rearrangement analysis showed germline configuration and the result of in situ hybridization for Epstein-Barr virus-encoded RNA (EBER-ISH) was positive. The patient has undergone an aggressive clinical course and died of multi-organ function failure 14 days later after admission. To the best of our knowledge, this is the first case of ANKL with spontaneous splenic rupture, and we should pay more attention to recognize it.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2048154883890867

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Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report

Cited by 12 publications

References 35 publications

CyclinD1, a prominent prognostic marker for endometrial diseases

CyclinD1, a prominent prognostic marker for endometrial diseases

A case of enteropathy-associated T-cell lymphoma (Type I) arising in stomach without refractory celiac disease

Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature

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