Peripheral Vascular Disease in Diabetes

Svahn, Jennifer K.; Kirk, Jeffrey S.; Llaguna, Omar H.; Habib, Nancy

doi:10.1007/978-0-387-09841-8_24

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oscillation initiation and propagation requires cross talk between the endothelium and vascular smooth muscle leading to alterations in intracellular calcium (Ca 2þ ) levels in the latter [26]. Abnormalities in endothelial cell (EC) function result in abnormal blood vessel oscillatory activity and subsequent reduced perfusion of a range of vascular beds; this may account for the increased vascular resistance observed in PE [27] and prevalence of peripheral vascular disease in diabetic patients [28,29]. Endothelial dysfunction is associated with obesity but whether tone oscillations are altered in obese pregnancy is unknown.…”

Section: Introductionmentioning

confidence: 99%

Maternal Obesity Impairs Specific Regulatory Pathways in Human Myometrial Arteries1

Hayward

Cowley

Mills

et al. 2014

Biology of Reproduction

View full text Add to dashboard Cite

Obese women (body mass index ≥30 kg/m(2)) are at greater risk than normal weight women of pregnancy complications associated with maternal and infant morbidity, particularly the development of cardiovascular disease and metabolic disorders in later life; why this occurs is unknown. Nonpregnant, obese individuals exhibit systemic vascular endothelial dysfunction. We tested the hypothesis that obese pregnant women have altered myometrial arterial function compared to pregnant women of normal (18-24 kg/m(2)) and overweight (25-29 kg/m(2)) body mass index. Responses to vasoconstrictors, U46619 (thromboxane mimetic) and arginine vasopressin, and vasodilators, bradykinin and the nitric oxide donor sodium nitroprusside, were assessed by wire myography in myometrial arteries from normal weight (n = 18), overweight (n = 18), and obese (n = 20) women with uncomplicated pregnancies. Thromboxane-prostanoid receptor expression was assessed using immunostaining in myometrial arteries of normal weight and obese women. Vasoconstriction and vasodilatation were impaired in myometrial arteries from obese women with otherwise uncomplicated pregnancies. Disparate agonist responses suggest that vascular function in obese women is not globally dysregulated but may be specific to thromboxane and nitric oxide pathways. Because obesity rates are escalating, it is important to identify the mechanisms underlying impaired vascular function and establish why some obese women compensate for vascular dysfunction and some do not. Future studies are needed to determine whether central adiposity results in an altered endocrine milieu that may promote vascular dysfunction by altering the function of perivascular adipose tissue.

show abstract