Peripherally and Centrally Mediated Bradycardiac Effects of Clonidine in Anesthetized or Spinal Rats

Ozawa, Hiroki; Uematsu, Toshio

doi:10.1620/tjem.119.283

Cited by 1 publication

(1 citation statement)

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“…The lipid/cholesterol feedback mechanism has been well defined, however the mechanisms by which nutrient deprivation/caloric restriction regulates SREBP1c precursors has remained poorly understood. Mature SREBPs accumulate in the nucleus of mouse hepatocytes following feeding, in contrast to fasting-mediated inhibition of SREBP1 nuclear localization [ 68 ]. Giandomenico and colleagues demonstrated that the nuclear/mature form of SREBP1c was acetylated, and that ac-SREBP1 was less ubiquitinated due to competitive binding of acetyl groups to lysine residues.…”

Section: Sirt1 Inhibition Of Srebp1c and Fatty Acid (Fa) Synthesismentioning

confidence: 99%

Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

Simmons

Pruitt

2015

IJMS

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SIRT1, an NAD+-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metabolic programs in response to diverse physiological stress. Interestingly, many of the metabolic pathways that are influenced by SIRT1 are also altered in tumor development. Not only does SIRT1 have the potential to regulate oncogenic factors, it also orchestrates many aspects of metabolism and lipid regulation and recent reports are beginning to connect these areas. SIRT1 influences pathways that provide an alternative means of deriving energy (such as fatty acid oxidation and gluconeogenesis) when a cell encounters nutritive stress, and can therefore lead to altered lipid metabolism in various pathophysiological contexts. This review helps to show the various connections between SIRT1 and major pathways in cellular metabolism and the consequence of SIRT1 deregulation on carcinogenesis and lipid metabolism.

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Section: Sirt1 Inhibition Of Srebp1c and Fatty Acid (Fa) Synthesismentioning

confidence: 99%