Periphery signals generated by Piezo-mediated stomach stretch and Neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor

Role of Ion Channels in the Chemotransduction and Mechanotransduction in Digestive Function and Feeding Behavior

“…Diuretic hormone 44 (DH44) neurons sense nutrients and are stimulated by sugar. Piezo, activated by crop enlargement during feeding, inhibits the activity of DH44 neurons and regulates feeding behavior [ 52 ]. Piezo-mediated feeding regulation depends on multiple neural loops, which inhibit DH44 neuron activity and increase Dlip2 neuron activity.…”

Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

“…Six DH44-expressing neuronal cells, located adjacent to IPCs (Figure 2B), detect the nutritional value of sugar and consumption of sugar macronutrient specifically during food deprivation (Figure 2B) (Dus et al, 2011(Dus et al, , 2015. When animals are satiated in the fed state, Piezo suppresses the function of DH44 neurons, thereby suppressing sugar intake (Oh et al, 2021). In future studies, it will be interesting to explore whether Piezo expression and/or activity are regulated by the postmating signals recently reported to increase maternal food intake through modulation of Ms neurons, a third population of cropinnervating neurons (Hadjieconomou et al, 2020).…”

Recent advances in chiral nanomaterials with unique electric and magnetic properties

“…It is ubiquitous in nature and numerous chiral substances are present in our body exemplified by amino acids that exist only as left-handed, l -enantiomers, and sugars exist as right-handed, d -enantiomers [ 2 ]. Homochirality of these molecules is essential for biological structures forming complex living systems [ 3 ] and is considered to be a physiological process showing high stereo-selectivity, which endows chiral with a biological system, depending on their handedness [ 4 ]. Along with biochemistry, chirality is also common in physics.…”