Periprostatic Perineurioma, Description of a Case With Unusual Localization

Abstract

Perineurioma is a rare entity, it is a benign peripheral nerve sheath tumor entirely composed of perineurial cells. A 62-year-old male patient was admitted to our hospital, suffering from scrotal and pelvic pain combined with a severe and continuous pain in his right thigh. A transrectal ultrasound revealed a periprostatic oval lesion of about 5 cm in maximum diameter. A sovrapubic laparotomy was performed with a complete tumor excision. The morphological and immunohistochemical data were most consistent with the diagnosis of perineurioma.

A Rare Case of Bladder Perineurioma

“…First described in 1978 by Lazarus and Trombetta, perineuriomas are tumors derived from perineural cells and belong to the category of benign nerve sheath neoplasms along with neurofibromas and schwannomas [1,2]. The perineurium is part of the supportive structure of the nerve trunk; it is a lamellar structure formed by one to six rows of flattened cells and a variable amount of connective tissue that surrounds the nervous fascicles constituted by axons, Schwann cells, and endoneurium, functioning as mechanical protection and individual blood-brain barrier for each fascicle [1,3,4].…”

“…They represent approximately 1% of all soft tissue neoplasms [1,2]. There are about 200 cases described in the literature, which are slightly more common in adult women [3].…”

“…Perineuriomas basically appear in two main forms: intraneural, restricted to the limits of peripheral nerves, and extraneural, mainly found in the skin and soft tissues of the trunk and limbs [4]. Head, neck, and visceral organs are rarely affected [3], and there are no reports in the literature that describe bladder perineurioma.…”