Peritoneal Carcinomatosis in Non-Small-Cell Lung Cancer: Retrospective Multicentric Analysis and Literature Review

Abbate, Maria Ida; Cortinovis, Diego; Tiseo, Marcello; Vavalà, Tiziana; Cerea, Giulio; Toschi, Luca; Canova, Stefania; Colonese, Francesca; Bidoli, Paolo

doi:10.2217/fon-2018-0469

Cited by 8 publications

(19 citation statements)

References 9 publications

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“…It could be that presence of driver mutation can be related to faster disease progression and development of PC. Nevertheless, larger studies did not identify statistically significant association between development of PC and presence of EGFR, KRAS and ALK mutations 5 6. There is very limited data on impact of the rare mutations including ROS1, MET and BRAF on development of PC in lung cancer patients.…”

Section: Discussionmentioning

confidence: 96%

“…It is unclear what factors predispose to the peritoneal spread of lung cancer. The most common histological type associated with the peritoneal metastasis is adenocarcinoma 5. Many patients with PC have malignant pleural effusions suggesting that peritoneal spread may be related to serosal communication with metastatic seeding, however, cases of isolated PC without pleural or other site metastasis have been reported 6 9.…”

Section: Discussionmentioning

confidence: 99%

“…Among the reviewed literature in English, only three patients with PC and NSCLC were tested for ROS1 and only one tested positive. Similarly, only four patients were evaluated for MET expression and two of them were positive 5. BRAF mutation was described only in one case report in coexistence with oncogenic KRAS G12A mutations in a patient with lung squamous cell carcinoma and PC 12.…”

Section: Discussionmentioning

confidence: 99%

“…Peritoneal spread is rare in lung cancer with a reported incidence of 1.2% on clinical diagnosis 4. Peritoneal carcinomatosis (PC) usually develops late in the disease process and is rarely seen at the time of cancer diagnosis 5 6. There are limited data on the factors that predict peritoneal progression.…”

Section: Introductionmentioning

confidence: 99%

“…It has been proposed that the oncogene profile of the tumour might predispose to different metastatic patterns 7. Several common mutations have been analysed including epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) and Kirsten rat sarcoma (KRAS) viral oncogene, but no statistically significant association with PC was found 5 6. On review of the literature published in English, testing for c-ROS oncogene 1 (ROS1) was reported only in three patients with non-small cell lung cancer (NSCLC) with peritoneal spread and returned positive in one of them.…”

Section: Introductionmentioning

confidence: 99%

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ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation

et al. 2020

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Peritoneal carcinomatosis (PC) is progression of the primary cancer to the peritoneum that is seen in only 1.2% of patients with lung cancer. It is associated with poor prognosis especially if present at the time of initial cancer diagnosis. The predisposing factors for peritoneal spread are not yet well understood. It has been suggested that the oncogene status of the tumour can influence the patterns of metastatic spread. There is not enough data about the role of c-ROS oncogene 1 (ROS1) mutation in the development of PC in non-small cell lung cancer. Here, we describe a case of a 56-year-old man who presented with new-onset ascites and was found to have PC. He was diagnosed with ROS1-rearranged lung adenocarcinoma. No obvious primary tumour was identified. Patient responded well to targeted therapy with crizotinib and remained 6 months free of disease progression.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation

et al. 2020

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Peritoneal carcinomatosis secondary to metastatic lung cancer complicated with acute suppurative appendicitis: A case report and literature review

Fu¹,

Wang²,

Xia

et al. 2022

Medicine

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Rationale: Lung cancer (LC) is a malignant tumor with the highest morbidity and mortality in the world. The most common metastatic sites of LC are the brain (47%), bone (36%), liver (22%), adrenal glands (15%), thoracic cavity (11%) and distant lymph nodes (10%). Peritoneal carcinomatosis (PC) is a rare clinical event in LC patients. Considering the rarity and nonspecific clinical symptoms of peritoneal metastasis among LC patients, a case of peritoneal metastasis secondary to LC incidentally observed by laparoscopic appendectomy is unusual.Patient concerns: Here, we present a 53-year-old never-smoker woman who presented to the emergency department with a 2-day history of pain in the right abdominal quadrant. Later, laparoscopy revealed acute suppurative appendicitis accompanied by a peritoneal metastatic mass. Diagnosis:The patient was diagnosed with PC secondary to metastatic LC complicated with acute suppurative appendicitis by immunohistochemistry. Positron emission tomography computed tomography (PET CT) findings further strengthen the evidence of PC from LC.Outcomes: Based on the results of genomic analysis, the patient received targeted therapy with osimertinib 80 mg/d.Lessons: Due to the discovery of new targets, the use of molecular therapies improved progression-free survival (PFS) and overall survival (OS), which increases the chance of identifying peritoneal metastasis of LC. For LC patients with abdominal symptoms, clinicians should be aware of the possibility of peritoneal metastasis from LC, especially for patients diagnosed with lung adenocarcinoma or with pleural effusion.Abbreviations: CT = computed tomography, EGFR = epidermal growth factor receptor, LC = Lung cancer, mOS = median overall survival, NSCLC = non-small cell lung cancer, OS = overall survival, PC = peritoneal carcinomatosis, PET CT = positron emission tomography computed tomography, PFS = progression-free survival, TKIs = tyrosine kinase inhibitors.

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Surgical treatment of intraperitoneal metastases from lung cancer: two case reports and a review of the literature

et al. 2019

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Background Peritoneal metastases are often reported in several abdominal tumors. Peritoneal diffusion from extra-abdominal tumors is thought to be rare. Lung cancer is one of the most common cancers in the world with early metastases and it is associated with poor prognosis in advanced stages. Peritoneal metastases from lung cancer are uncommon and the real mechanism of its diffusion to the peritoneum is unknown. However, its clinical behavior is similar to any other peritoneal metastasis from abdominal tumors. Case presentation We present two Caucasian patients (a 44-year-old man and a 59-year-old man) with bowel obstruction from peritoneal metastases from non-small cell lung cancer who successfully underwent emergency cytoreductive surgery and had a good prognosis and survival. Conclusions In our patients with isolated peritoneal metastases from lung cancer, cytoreduction showed good prognosis with acceptable morbidity. This treatment option might be considered in highly selected cases to improve survival. Strict follow-up is mandatory to allow early diagnosis of peritoneal diffusion.

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Peritoneal Carcinomatosis in Non-Small-Cell Lung Cancer: Retrospective Multicentric Analysis and Literature Review

Cited by 8 publications

References 9 publications

ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation

ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation

Peritoneal carcinomatosis secondary to metastatic lung cancer complicated with acute suppurative appendicitis: A case report and literature review

Surgical treatment of intraperitoneal metastases from lung cancer: two case reports and a review of the literature

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