Peritoneal Dialysis

Al-Natour, Mohammed; Thompson, Dustin

doi:10.1055/s-0036-1571804

Cited by 12 publications

(11 citation statements)

References 8 publications

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“…Peritoneal dialysis (PD) is one of the most important renal replacement therapies in patients with end-stage renal disease (ESRD) (2). Peritoneal fibrosis (PF) is a severe complication of long-term PD that leads to the failure of peritoneal function and is a major clinical challenge.…”

Section: Introductionmentioning

confidence: 99%

MiR-200a negatively regulates TGF-β₁-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression

Guo

Hao

et al. 2018

American Journal of Physiology-Renal Physiology

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Although epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells was recognized as the key process of peritoneal fibrosis, which is a major cause of peritoneal failure related to peritoneal dialysis (PD), mechanisms underlying these processes remain largely unknown. In this study, we found that miR-200a was significantly downregulated in peritoneal tissues with fibrosis in a rat model of PD. In vitro, transforming growth factor (TGF)-β-induced EMT, identified by de novo expression of α-smooth muscle actin and a loss of E-cadherin in human peritoneal mesothelial cells (HPMCs), was associated with downregulation of miR-200a but upregulation of zinc finger E-box-binding homeobox 1/2 (ZEB1/2), suggesting a close link between miR-200a and ZEB1/2 in TGF-β-induced EMT. It was further demonstrated that miR-200a was able to bind to the 3'UTR of ZEB1/2, and overexpression of miR-200a blocked TGF-β-induced upregulation of ZEB1/2 and, therefore, inhibited EMT and collagen expression. In contrast, overexpression ZEB1/2 blocked miR-200a inhibition of EMT and collagen expression in HMPCs. In conclusion, miR-200a could negatively regulate TGF-β-induced EMT by targeting ZEB1/2 in peritoneal mesothelial cells. Blockade of EMT in HPMCS indicates the therapeutic potential of miR-200a as a treatment for peritoneal fibrosis associated with PD.

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Section: Introductionmentioning

confidence: 99%

MiR-200a negatively regulates TGF-β₁-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression

Guo

Hao

et al. 2018

American Journal of Physiology-Renal Physiology

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“…It was then decided that PD would be favoured despite prior major abdominal surgery and the presence of a neobladder, which are relative contraindications for PD. 6,11,12…”

Section: Discussionmentioning

confidence: 99%

Neobladder creation is still a conduit to peritoneal dialysis – Successful use of peritoneal dialysis after invasive bladder cancer

2021

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Peritoneal dialysis (PD) is as safe and more cost-effective than haemodialysis (HD). It also allows patients to undergo renal replacement therapy (RRT) from home. However, PD remains underutilised in many parts of the world. This is true in part because of many perceived relative contraindications to PD, including a history of prior major abdominal surgery. Prior major abdominal surgery is a concern for standard bedside or surgical catheter placement since these patients are at risk of having adhesions, which can complicate catheter placement. However, with laparoscopic advancements, prior major abdominal surgery is no longer even a relative contraindication to PD for skilled and experienced surgeons. We report the case of a male in his 70s with a history of cystoprostatectomy which was curative for a muscle invasive bladder carcinoma 5 years prior to his RRT. The patient had longstanding chronic kidney disease which worsened gradually. After receiving RRT education, the patient favoured PD. The catheter was placed despite the surgeon noting abdominal adhesions and the patient successfully underwent 12 months of PD which had a positive impact on his quality of life. He transferred to HD after contracting a complex PD-associated peritonitis. Thus, new research should be conducted to better understand the real impact of prior abdominal surgeries as a contraindication to PD, especially in centres where the surgeons have experience with advanced laparoscopy.

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“…[ 11 ] In addition, the annual percentage of patients undergoing PD worldwide has enhanced by 8%, higher than the percentage of hemodialysis. [ 12 ]…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Omaha system-based nursing management on nutritional status in patients undergoing peritoneal dialysis

Peng

Gao²,

Lü³

et al. 2020

Medicine

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The chronic kidney disease (CKD) patients may have a variety of complications during receiving peritoneal dialysis (PD). The malnutrition in CKD patients is related to their lower life quality, higher hospitalization rates, and higher risk of cardiovascular disease, as well as the increased morbidity and mortality. Hence, it is very important to monitor and then manage the nutritional status of CKD patients. Thus, we perform this randomized controlled study protocol to introduce a continuing nursing program based on Omaha system (OS) for the patients with CKD receiving PD treatment. The randomized trial will be implemented from November 2020 to May 2021 and was granted through the Research Ethics Committee of Wuhan No.1 Hospital (2020003281). Two hundred patients meet inclusion criteria and exclusion criteria are included. Patients who meet the following criteria will be selected: voluntary participation, aged 20 to 60; undergoing the regular PD treatment for at least 3 months. Patients will be excluded if the patients are in unstable status, or experience the intermittent PD or some other kinds of dialysis mode, have severe cachexia, infection, or malnutrition, or if they have mental disorders. In control group, patients are given routine treatment, containing general guidance associated with PD and the outpatient telephone calls from the clinical nurses during follow-up. In study group, the patients are given the continuous nursing treatment scheme based on OS. The clinical results are the biochemical parameters after intervention, anthropometry, as well as the subjective global assessment. Table 1 reveals the clinical endpoints between the 2 groups. This protocol can guide nurses to develop a nursing program based on evidence for patients with CKD receiving PD. Trial registration: This study protocol was registered in Research Registry (researchregistry6202).

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Peritoneal Dialysis

Cited by 12 publications

References 8 publications

MiR-200a negatively regulates TGF-β₁-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression

MiR-200a negatively regulates TGF-β₁-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression

Neobladder creation is still a conduit to peritoneal dialysis – Successful use of peritoneal dialysis after invasive bladder cancer

Efficacy of Omaha system-based nursing management on nutritional status in patients undergoing peritoneal dialysis

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Peritoneal Dialysis

Cited by 12 publications

References 8 publications

MiR-200a negatively regulates TGF-β1-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression

MiR-200a negatively regulates TGF-β1-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression

Neobladder creation is still a conduit to peritoneal dialysis – Successful use of peritoneal dialysis after invasive bladder cancer

Efficacy of Omaha system-based nursing management on nutritional status in patients undergoing peritoneal dialysis

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Product

Resources

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MiR-200a negatively regulates TGF-β₁-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression

MiR-200a negatively regulates TGF-β₁-induced epithelial-mesenchymal transition of peritoneal mesothelial cells by targeting ZEB1/2 expression