Peritoneal Dialysis: A Review

Mattocks, Albert M.; El-Bassiouni, E. A.

doi:10.1002/jps.2600601202

Cited by 16 publications

(1 citation statement)

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“…In humans peritoneal dialysis is used for the treatment of acute and chronic renal failure as well as for removal of dialyzable exogenous and endogenous poisons (Mattocks and El-Bassiouni, 1971;Jones, 1971). Various authors have investigated the membrane transport of drugs and other xenobiotics in vitro (Shenouda and Mattocks, 1967;Gosselin and Berndt, 1962), and drug transport in the stomach and small intestine has been investigated in considerable detail (Schanker et ai, 1957(Schanker et ai, , 1958.…”

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confidence: 99%

Transport of Model Compounds across the Peritoneal Membrane in the Rat

Torres

Litterst

Guarino³

1978

Pharmacology

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The absorption into the systemic circulation of compounds administered intraperitoneally in large volumes was investigated in the rat. The influence on absorption of molecular weight, lipid-water partition coefficient (K), and dissociation constant (pKa) was studied. Nine neutral compounds ranging in molecular weight from 18 to 2 million demonstrated absorptions that decreased with increasing molecular weight. Five compounds were tested with variable lipid partition (K) values (0.001–3.3) and the absorptions increased from 57 to 96% as the K values increased. A series of nine acids and bases covering a wide range of pKa values (0.9–9.9) were investigated. For the acids, absorption increased with increasing pKa value, while for the bases absorption decreased with increasing pKa. For both groups of compounds absorption was directly related to the extent of ionization at physiologic pH. As has been documented for other biological membranes, the peritoneal membrane in the rat was found to behave in a lipoid manner. Unionized or lipid-soluble compounds are absorbed to a greater extent than ionized or lipid-insoluble compounds, and neutral compounds are absorbed in relation to their molecular weights.

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confidence: 99%