Peritoneal dialysis fluid induces change of mononuclear phagocyte proportions

Bos, H. J.; Meyer, F. De; Veld, J. C. de; Beelen, Robert H.J.

doi:10.1038/ki.1989.155

Cited by 44 publications

(18 citation statements)

References 17 publications

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“…This pathway could be represented by inflammatory gaps at 37°C, which are not present to the same extent at 19°C [30, 31], causing a markedly increased leakage of LDL and other very large proteins in control animals. Thus, a local sterile inflammatory state seems to be induced by the administration of PD fluids in rats [32]and in patients [33]during a PD dwell. Furthermore, the plasma membranes become ‘stiffer’ at low temperatures, which would decrease the ability of large molecules, like LDL, to pass the endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Transvascular Passage of Macromolecules into the Peritoneal Cavity of Normo- and Hypothermic Rats in vivo: Active or Passive Transport?

Rosengren¹,

Carlsson²,

Venturoli³

et al. 2004

J Vasc Res

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During the last decades there has been a debate regarding whether transvascular protein transport is an active (transcytosis) or a passive (porous) process. To separate cooling-sensitive transcytosis from passive transport processes between blood and peritoneal fluid, we induced hypothermia in rats in vivo, reducing their body temperature to 19°C. Control rats were kept at 37°C. Either human albumin, or IgG, or IgM, or LDL, radiolabeled with ¹²⁵I, was given intra-arterially together with ⁵¹Cr-EDTA. During tracer administration, a 2-hour peritoneal dialysis dwell was performed. Clearance of the tracers to dialysate, and the permeability-surface area coefficient (PS) for ⁵¹Cr-EDTA and glucose were assessed. During cooling, mean arterial blood pressure (MAP) was reduced to 40% of control and plasma viscosity increased by 48.5%, while peritoneal blood flow was reduced to 10%. At 19°C, clearance of albumin to dialysate fell from 9.30 ± 1.62 (SEM) to 3.13 ± 0.28 µl/min (p < 0.05), clearance of IgG from 6.33 ± 0.42 to 2.54 ± 0.12 µl/min (p < 0.05), clearance of IgM from 3.65 ± 0.33 to 1.10 ± 0.12 µl/min (p < 0.05), and clearance of LDL from 3.54 ± 0.20 to 0.73 ± 0.06 µl/min (p < 0.05). The fall in PS for ⁵¹Cr-EDTA was from 0.320 ± 0.01 to 0.075 ± 0.003 ml/min (p < 0.05), and that for glucose from 0.438 ± 0.02 to 0.105 ± 0.01 ml/min (p < 0.05). Tissue cooling reduced large solute transport largely in proportion to the cooling-induced reductions of MAP (to 40%), and the concomitant increase in viscosity (to 67%), i.e. to ≈20–30% (0.40 × 0.67) of control, though LDL clearance was reduced further. The fall in small solute PS, in excess of the viscosity effect, mirrored the fall in peritoneal blood flow occurring during hypothermia. In conclusion, the good correlation of predicted to calculated changes suggests that the overall transendothelial macromolecular passage in vivo occurs passively, and not due to active processes.

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Section: Discussionmentioning

confidence: 99%

Transvascular Passage of Macromolecules into the Peritoneal Cavity of Normo- and Hypothermic Rats in vivo: Active or Passive Transport?

Rosengren¹,

Carlsson²,

Venturoli³

et al. 2004

J Vasc Res

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“…Davies et al [4] reported that, when exposed to opsonized zymosan, peritoneal mac rophages from the uninfected CAPD patients show fea tures of maturation and activation, and evidence of the Accepted: July 14.1993 augmented generation of free radicals. Finally, even the intraperitoneal infusion of saline activates peritoneal leu kocytes and this process is more pronounced after exposure of the peritoneum to dialysis fluid [5].…”

Section: Introductionmentioning

confidence: 99%

Glycosaminoglycan Chondroitin Sulphate Prevents Loss of Ultrafiltration during Peritoneal Dialysis in Rats

Bręborowicz

Wieczorowska

Martis

et al. 1994

Nephron

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We evaluated the effect of 6 days of intraperitoneal saline infusion on peritoneal peroxidation and permeability in rats. Peroxidation of the peritoneum as measured by malondialdehyde concentration in the omentum was increased and there was a concomitant augmented membrane permeability to glucose and resulted in a loss of ultrafiltration. In vitro experiments with mesothelial cells showed that glycosaminoglycan chondroitin sulphate appears to act as a scavenger of free radicals and so protects the mesothelial cells against injury. Thus, in rats, supplementation of the infused saline with chondroitin sulphate reduces peroxidation of the peritoneum and prevents loss of ultrafiltration during peritoneal dialysis. These results suggest that chondroitin sulphate may be effective in preventing the deterioration of peritoneal permeability during chronic peritoneal dialysis. This beneficial effect probably derives from the scavenging of free radicals by chondroitin sulphate.

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“…Five days after infection cytospin preparations were made as described (19). The immunoperoxidase staining of acetone-fixed cytospin centrifuge preparations used standard procedures (20) separated by Percoll gradient centrifugation ( Fig. 1).…”

mentioning

confidence: 99%

Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures.

Langhoff

Terwilliger

Bos

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

149

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The ability of the human immunodeficiency virus type 1 (mHV-1) to replicate in primary blood dendritic cells was investigated. Dendritic cells compose <1% of the circulating leukocytes and are nondividing cells. Highly purified preparations of dendritic cells were obtained using recent advances in cell fractionation. The results of these experiments show that dendritic cells, in contrast to monocytes and T cells, support the active replication of all strains of HIV-1 tested, including T-cell tropic and monocyte/macrophage tropic isolates. The dendritic cell cultures supported much more virus production than did cultures of primary unseparated T cells, CD4+ T cells, and adherent as well as nonadherent monocytes.

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Peritoneal dialysis fluid induces change of mononuclear phagocyte proportions

Cited by 44 publications

References 17 publications

Transvascular Passage of Macromolecules into the Peritoneal Cavity of Normo- and Hypothermic Rats in vivo: Active or Passive Transport?

Transvascular Passage of Macromolecules into the Peritoneal Cavity of Normo- and Hypothermic Rats in vivo: Active or Passive Transport?

Glycosaminoglycan Chondroitin Sulphate Prevents Loss of Ultrafiltration during Peritoneal Dialysis in Rats

Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures.

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