Introduction: Inadequate dialysis and fluid overload are corrected after starting combined therapy with peritoneal dialysis (PD) and hemodialysis (HD). However, the effects on anemia management has not been elucidated.
Methods:We conducted a prospective, multicenter, observational cohort study of 40 PD patients (age, 60 ± 10 years; male, 88%; median PD duration, 28 months) starting combined therapy and investigated changes in several clinical parameters, including erythropoiesis-stimulating agent (ESA) resistance index (ERI).Results: ERI decreased significantly during 6 months after switching to combined therapy ] units/week/kg/(g/dL) to 7.8 [IQR 3.9-18.6] units/week/kg/(g/dL), p = 0.047). Body weight, urinary volume, serum creatinine and the dialysate-to-plasma creatinine ratio (D/P Cr) decreased, whereas hemoglobin and serum albumin increased. In subgroup analysis, the changes in ERI were not affected by cause for starting combined therapy, PD holiday and D/P Cr.
Conclusion:Although detailed mechanism was unclear, ESA responsiveness improved after switching from PD alone to combined therapy. K E Y W O R D S dialysate-to-plasma ratio of creatinine (D/P Cr), erythropoiesis-stimulating agent (ESA), ESA resistance index (ERI), residual kidney function (RKF), β2 microglobulin