Peritoneal dialysis in the reduction of blood ammonia levels in a case of hyperammonaemia.

Herrin, John T.; McCredie, David A.

doi:10.1136/adc.44.234.149

Cited by 30 publications

(5 citation statements)

References 11 publications

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“…and 54 hours after operation peritoneal dialysis was begun. Details of temporary clinical improvement, associated with a considerable fall in blood ammonia, are described elsewhere in this journal (Herrin and McCredie, 1969). However, on the fifth post-operative day, blood pressure gradually declined, and after several cardiac arrests she died 5 days after operation.…”

mentioning

confidence: 91%

Hyperammonaemia Due to Ornithine Transcarbamylase Deficiency

Hopkins¹,

Connelly²,

Dawson³

et al. 1969

Archives of Disease in Childhood

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mentioning

confidence: 91%

Hyperammonaemia Due to Ornithine Transcarbamylase Deficiency

Hopkins¹,

Connelly²,

Dawson³

et al. 1969

Archives of Disease in Childhood

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“…The diagnosis of hyperammonemia should be made as quickly as possible to start emergency treatment [1][2][3][4][5][6][7][8]. Exogenous detoxification with peritoneal or extracorporeal dialysis should be applied rapidly to reduce plasma ammonia levels in patients who are not responsive to pharmacological and dietary treatment [9][10][11][12][13][14][15][16][17][18]. In comparison with PD, both intermittent traditional HD and CRRT proved more efficacious in rapidly removing plasma ammonia [8,[19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Peritoneal dialysis in neonates with inborn errors of metabolism: is it really out of date?

et al. 2008

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Peritoneal and extracorporeal dialysis are used to treat newborns affected by inborn errors of metabolism to minimize the effects of the acute accumulation of neurotoxic metabolites that can produce irreversible and severe neurological damage and even death. In recent papers, extracorporeal dialysis has been described as more effective than peritoneal dialysis in improving the prognosis in newborns with inborn errors of metabolism and hyperammonemia. However, it appears that the outcome is primarily related to the duration of neonatal hyperammonemic coma. Here we report seven newborns with hyperammonemia caused by inborn errors of metabolism (five with organic acidemias, two with urea-cycle disorders). They received dietetic and pharmacological treatment as well as peritoneal dialysis. Four of the five patients with organic acidemia survived with and without mild neurological impairment (follow-up 3.5-10 years). One died from bacterial sepsis after peritoneal dialysis was discontinued and the peritoneal catheter was removed. One of the two patients affected by urea-cycle disorders, a boy, died during the neonatal period, and the other, a girl, died at the age of 13 months due to severe neurological damage. Our results demonstrate that peritoneal dialysis may still be an effective treatment for neonatal hyperammonemia caused by inborn errors of metabolism. Furthermore, peritoneal dialysis can be administered quickly and easily in all settings, clearly an advantage when fast intervention is so crucial.

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“…Aus diesen Gründen wird das Verfahren von zahlreichen Autoren insbesondere in der akuten Behandlung von schwerkranken Kindern bevorzugt angewendet [10,12,13,16,19,21,26,34]. Als ein kontinuierliches intrakorporales Verfahren ist eine hämodynamisch schonende Blutreinigung möglich.…”

Section: Diskussionunclassified