Peritoneal Dialysisinukraine: 2009–2013

Saidakova, N.O.; Kozlyuk, N.; Nikolaenko, S. S.; Stepanova, N.

doi:10.31450/ukrjnd.4(44).2014.01

Cited by 2 publications

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“…Вступ. В Україні близько 12% пацієнтів з хронічною хворобою нирок V Д стадії лікуються методом перитонеального діалізу (ПД) [1]. На відміну від гемодіалізної популяції, ПД пацієнти отримують лікування вдома, що зменшує імовірність інфікування SARS-CoV-2 [1][2][3].…”

Section: резюме в україні близько 12% пацієнтів з хронічною хворобоюunclassified

“…В Україні близько 12% пацієнтів з хронічною хворобою нирок V Д стадії лікуються методом перитонеального діалізу (ПД) [1]. На відміну від гемодіалізної популяції, ПД пацієнти отримують лікування вдома, що зменшує імовірність інфікування SARS-CoV-2 [1][2][3]. Тим не менш, старша вікова категорія, цукровий діабет, артеріальна гіпертензія та інші численні коморбідні стани ПД пацієнтів суттєво підвищують ризик їх інфікування [3][4][5].…”

Section: резюме в україні близько 12% пацієнтів з хронічною хворобоюunclassified

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Management of peritoneal dialysis facilities and services during the COVID-19 pandemic: Adapted clinical guidelines of the Ukrainian Association of Nephrologists and Kidney Transplant Specialists

Kolesnyk¹,

Stepanova²,

Dudar³

et al. 2020

Ukr. J. Nephrol. and Dial.

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In Ukraine, about 12% of end-stage renal disease patients are treated by peritoneal dialysis (PD). In contrast to the hemodialysis population, PD patients receive treatment at home, which reduces the likelihood of SARS-CoV-2. However, older age, diabetes, hypertension and many other comorbid conditions of PD patients significantly increase the risk of infection. Therefore, maximum adherence to preventive measures for COVID-19 by PD patients and medical staff is an urgent and mandatory task. Based on the published research on COVID-19, the expert group of the Ukrainian Association of Nephrologists and Kidney Transplant Specialists has created the Adapted Clinical Guidelines for the Management of Peritoneal Dialysis Facilities and Services During the COVID-19 pandemic. All of the following clinical guidelines have a level of evidence of 2C.

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Section: резюме в україні близько 12% пацієнтів з хронічною хворобоюunclassified

Management of peritoneal dialysis facilities and services during the COVID-19 pandemic: Adapted clinical guidelines of the Ukrainian Association of Nephrologists and Kidney Transplant Specialists

Kolesnyk¹,

Stepanova²,

Dudar³

et al. 2020

Ukr. J. Nephrol. and Dial.

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“…In China, recent annual growth of patients on PD exceeded 20% (from 37942 patients in 2012 to 55373 in 2014) [1,2]. In Ukraine, the number of patients undergoing PD has also increased from 552 to 966 since 2009 through the end of 2013 [4]. However, PD solutions used in Ukraine come from abroad.…”

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confidence: 99%

“…Therefore, standard solutions for PD are considered to be bioincompatible with the peritoneal membrane because of hyperosmolarity, unphysiologically low values of pH (5.0-5.5), high lactate (35 or 40 mmol/l) and glucose contents (1.5-4.25%). The extent of bioincompatibility depends on the type of an osmolarly active compound (for example, glucose, icodextrin, aminoacids), pH, packaging , and other factors [2,4,5,[13][14][15]. In response to the effect of PD solutions, the cellular processes of exchange and regeneration, peroxidation and proliferation are intensified, and the activity of mitochondria and other cytoplasmic organelles increases in mesothelium cells.…”

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confidence: 99%

Biological and analytical studies of peritoneal dialysis solutions

Hudz¹,

Kobylinska²,

Dmytrukha³

et al. 2018

Ukr.Biochem.J.

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the purpose of our work was to conduct biological and analytical studies of the peritoneal dialysis (Pd) solutions containing glucose and sodium lactate and establish correlations between cell viability of the Vero cell line and values of analytical indexes of the tested solutions. The results of this study confirm the cytotoxicity of the Pd solutions even compared with the isotonic solution of sodium chloride, which may be due to the low pH of the solutions, presence of glucose degradation products (GdPs) and high osmolarity of the solutions, and unphysiological concentrations of glucose and sodium lactate. However, it is not yet known what factors or their combination and to what extent cause the cytotoxicity of Pd solutions. In the neutral red (Nr) test the weak, almost middle (r =-0.496 and 0.498, respectively) and unexpected correlations were found between reduced viability of monkey kidney cells and increased pH of the Pd solutions and between increased cell viability and increased absorbance at 228 nm of the tested Pd solutions. these two correlations can be explained by a strong correlation (r =-0.948) between a decrease in pH and an increase in the solution absorbance at 228 nm. The opposite effect was observed in the MTT test. The weak, but expected correlations (r = 0.32 and-0.202, respectively) were found between increased cell viability and increased pH in the Pd solutions and between decreased cell viability and increased absorbance at 228 nm of the tested Pd solutions. the middle and weak correlations (r = 0.56 and 0.29, respectively) were detected between increased cell viability and increased lactate concentration in the Nr test and mtt test. the data of these correlations can be partially explained by the fact that a correlation with a coefficient r =-0.34 was found between decreased pH in the solutions and increased lactate concentration. the very weak correlations (0.138 and 0.196, respectively) were found between increased cell viability and increased glucose concentration in the Nr test and mtt test. these experimental data indicate that pH is the dominating factor, which determines almost all of the established correlations. However, the character of the correlations is quite different: the higher the pH, the greater was the cell viability in the mtt test, and conversely, the higher the pH, the lower was the cell viability in the NR test. Secondly, the unexpected correlation coefficient was determined as-0.473 between decreased cell viability in the mtt test and increased cell viability in the Nr test. moreover, this phenomenon indicates that the mitochondrial enzyme succinate dehydrogenase is more vulnerable to the action of Pd solutions than membrane permeability. Finally, we conclude that the Nr test is not suitable for comparative studies of Pd solutions which differ in pH, as it is pH dependent and does not enable the comparison of plausible cell viability. K e y w o r d s: solutions for peritoneal dialysis, cell viability, kidney cells (Vero line), neutral red, mtt.

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Peritoneal Dialysisinukraine: 2009–2013

Cited by 2 publications

References 0 publications

Management of peritoneal dialysis facilities and services during the COVID-19 pandemic: Adapted clinical guidelines of the Ukrainian Association of Nephrologists and Kidney Transplant Specialists

Management of peritoneal dialysis facilities and services during the COVID-19 pandemic: Adapted clinical guidelines of the Ukrainian Association of Nephrologists and Kidney Transplant Specialists

Biological and analytical studies of peritoneal dialysis solutions

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