Peritoneal disease in breast cancer: A specific entity with an extremely poor prognosis

Tuthill, Mark; Pell, Robert; Guiliani, Rosa; Lim, Adrian; Gudi, Mihir; Contractor, Kaiyumars; Lewis, Jacqueline S.; Coombes, R. Charles; Stebbing, Justin

doi:10.1016/j.ejca.2009.04.027

Cited by 38 publications

(36 citation statements)

References 10 publications

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“…Only after histopathological confirmation of metastatic breast cancer, the primary tumor was discovered. Although a median survival of a maximum 26 months for patients with peritoneal metastases from ILC has been previously reported [7], our patient experience six years of a disease free state. Given the fact that this was a highly endocrine responsive lobular breast cancer, it may be assumed that long disease free interval was mainly the result of a positive effect of endocrine therapy, ovariectomy, and tamoxifen [8].…”

Section: Discussionmentioning

confidence: 93%

Invasive Lobular Breast Cancer Presenting an Unusual Metastatic Pattern in the Form of Peritoneal and Rectal Metastases: A Case Report

et al. 2011

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Gastrointestinal metastases from invasive lobular breast cancer are uncommon with the stomach and small intestines being the most common metastatic sites. Peritoneal and rectal metastases are very rare and only rarely occur as the first manifestation of disease. We herein report the case of a 47-year-old woman who presented with abdominal carcinomatosis as a first sign of invasive lobular breast carcinoma (ILC). Identifying the most important immunohistochemical markers for ILC: gross cystic disease fluid protein 15, estrogen and progesterone receptors enabled a correct diagnosis. After a six year disease-free period, relapse occurred with severe obstruction due to rectal metastasis from lobular breast carcinoma. Since there was no widespread metastatic disease, surgery with concomitant hormonal therapy was performed.

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Section: Discussionmentioning

confidence: 93%

Invasive Lobular Breast Cancer Presenting an Unusual Metastatic Pattern in the Form of Peritoneal and Rectal Metastases: A Case Report

et al. 2011

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“…In a prospective trial, patients treated with chemotherapy plus trastuzumab had an overall survival advantage as compared with those receiving chemotherapy alone (25.1 months vs. 20.3 months, p=0.05) (11). The prognosis of patients with breast cancer with peritoneal metastases is poor (less than 2 months) (12).…”

Section: Discussionmentioning

confidence: 99%

Orbital Metastasis as the Initial Presentation of Invasive Lobular Carcinoma of Breast

2012

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This is an unusual case of invasive lobular carcinoma of the breast presenting as an orbital metastasis. A 70 year-old female presented with a gradually worsening blurred vision, periorbital swelling and ascites. The biopsy of the eyelid demonstrated dense fibrosis with neoplastic cells and the diagnosis of carcinoma was made; however, the site of origin of carcinoma was difficult to determine. The histopathologic characteristics of the carcinoma in the orbit and ascites fluid combined with the immunophenotypic features helped determine the primary site of the malignancy. Subsequently, the primary malignancy was identified by examination of the patient's breast.

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“…PC from extra-abdominal tumors is very rare, and most current literature is based on case reports; among them, breast and lung cancer represent the most frequent tumors associated with PC. In a large study of 1,628 patients with breast cancer, Tuthill et al identified 44 patients (2.7 %) with PC who had a very poor prognosis (1.57 months) in the UK [38]. Another study of PC from lung cancer in an autopsy series showed a global incidence ranging from 2.7 % to 16 %, together with other sites of metastasis [39].…”

Section: Other Secondary Peritoneal Carcinomatosismentioning

confidence: 97%

Epidemiology: Extent of the Problem

Sibio

Atta²,

Impagnatiello³

et al. 2015

Treatment of Peritoneal Surface Malignancies

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Peritoneal carcinomatosis (PC) most commonly represents local or regional evolution of an abdominal carcinoma. Sometimes it can be synchronous with the primary tumor (primary carcinomatosis) but more often is present as recurrent disease (metachronous or secondary) after first-line treatment of the originating tumor. Patients with tumors from colon, ovary, and stomach cancer are more likely to present with PC during their clinical course. Less frequently, other abdominal malignancies, such as uterus, pancreas, small bowel, biliary, or urinary tract, can involve the peritoneum. Tumors originating from the peritoneum itself are definitely rarer: mesothelioma, pseudomyxoma peritonei (PMP), primitive peritoneal carcinoma, and desmoplastic small-round-cell tumor. PC from extra-abdominal tumors, such as lung, breast, melanoma, or peritoneal sarcomatosis, is exceptional, and few epidemiological data are available on them. Statistical analysis of worldwide cancer incidence, prevalence, and mortality rate is available on GLOBOCAN 2012 [1]. In Italy, most epidemiological data are available in the reports from the Italian Association of Tumor Registries (AIRTUM) [2], which collects data regarding incidence, prevalence, and mortality rates from all local and regional tumor registries, covering at least 34% of total population. This data is considered a high-quality regional coverage by and international ranking system (GLOBOCAN 2012 rate B)

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Peritoneal disease in breast cancer: A specific entity with an extremely poor prognosis

Cited by 38 publications

References 10 publications

Invasive Lobular Breast Cancer Presenting an Unusual Metastatic Pattern in the Form of Peritoneal and Rectal Metastases: A Case Report

Invasive Lobular Breast Cancer Presenting an Unusual Metastatic Pattern in the Form of Peritoneal and Rectal Metastases: A Case Report

Orbital Metastasis as the Initial Presentation of Invasive Lobular Carcinoma of Breast

Epidemiology: Extent of the Problem

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