Peritoneal metastatic disease in a child after excision of a solid pseudopapillary tumour of the pancreas: a unique case

Andronikou, Savvas; Moon, Anna; Ussher, R. G.

doi:10.1007/s00247-003-0875-z

Cited by 17 publications

(11 citation statements)

References 7 publications

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“…Andronikou et al [27] reported a case of a 15-year-old female with peritoneal metastases from a pancreatic SPN, which had been excised 6 years previously. Kyokane et al [28] described a case of a 58-year-old female who underwent a distal pancreatectomy for a SPN, who developed peritoneal dissemination 6.5 years after surgery.…”

Section: Discussionmentioning

confidence: 98%

Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: report of a case

et al. 2012

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A solid pseudopapillary neoplasm (SPN) of the pancreas is generally regarded as a neoplasm of low malignant potential and there is rarely recurrence of the disease. A 12-year-old female underwent a pylorus preserving pancreaticoduodenectomy for a ruptured pancreatic SPN following a blunt abdominal trauma. The tumor showed no pathological features suggesting malignant potential. Follow-up imaging studies depicted small nodules adjacent to the superior mesenteric vein 7 years after surgery. A laparotomy was performed, and exploration revealed 3 nodules adjacent to the superior mesenteric vein and 4 small nodules in the mesointestine. All of these lesions were extirpated, and were histologically confirmed to be nodal and peritoneal recurrence of SPN. This case indicates that SPN of the pancreas has a latent ability to recur, regardless of its benign pathological features, and peritoneal spread may be promoted by trauma. A close postoperative follow-up is thus mandatory in all patients with SPN even after a radical resection.

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Section: Discussionmentioning

confidence: 98%

Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: report of a case

et al. 2012

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“…However, the histopathological appearance and immunohistochemi- site. [1][2][3][4][5]8 There are multiple documented cases of longterm survival achieved by tumor resection of metastasizing SPTs even when residual disease remained. [3][4][5]9,15 Only nine fatalities have been reported, supporting our extensive surgical approach (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5]8 There are multiple documented cases of longterm survival achieved by tumor resection of metastasizing SPTs even when residual disease remained. [3][4][5]9,15 Only nine fatalities have been reported, supporting our extensive surgical approach (Table 3). 2,7,[15][16][17] Nevertheless, Tang et al 2 recently described two cases of clinically aggressive pancreatic SPTs, which were associated with a diffuse growth pattern, extensive tumor necrosis, an unusually high mitotic rate, and markedly increased Ki-67 immunoreactivity.…”

Section: Discussionmentioning

confidence: 99%

“…It is associated with a favorable prognosis: after complete removal, more than 95% of patients are cured. [1][2][3][4][5][6] A few cases of SPT exhibiting malignant behavior such as local recurrence and distant metastasis have been reported, but only exceptional cases have resulted in death, and the alterations of histopathological features and long-term follow-up of these cases have not been discussed in detail. 1,[3][4][5][7][8][9] Furthermore, SPTs rarely develop outside the pancreas.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] A few cases of SPT exhibiting malignant behavior such as local recurrence and distant metastasis have been reported, but only exceptional cases have resulted in death, and the alterations of histopathological features and long-term follow-up of these cases have not been discussed in detail. 1,[3][4][5][7][8][9] Furthermore, SPTs rarely develop outside the pancreas. [10][11][12][13][14] This is the first report describing a very unusual case of SPT, which developed in the greater omentum and metastasized initially to the liver, followed by repetitive intraabdominal recurrence.…”

Section: Introductionmentioning

confidence: 99%

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A solid pseudopapillary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential

Hibi¹,

Ojima²,

Sakamoto³

et al. 2006

J Gastroenterol

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Solid pseudopapillary tumor is a rare, indolent neoplasm almost exclusively seen in the pancreas. We describe an unusual case of solid pseudopapillary tumor arising in the greater omentum of a 45-year-old man with subsequent multiple liver metastases and peritoneal dissemination. The patient underwent a total of ten laparotomies and died of unresectable disease 8 years after the initial presentation. Microscopically, the primary tumor and the relapsed tumors consistently exhibited identical growth patterns, which were characterized by solid sheets intermingling with pseudopapillary arrangements of uniformly small cells. Immunohistochemical staining was diffusely positive for vimentin and focally positive for alpha-1-antitrypsin. These features were compatible with those of conventional pancreatic solid pseudopapillary tumors. We also performed quantitative evaluation of Ki-67 immunoreactivity and mitotic figures, which indicated malignant transformation of this extremely rare tumor. This is the first detailed report of solid pseudopapillary tumor arising outside the pancreas complicated by repetitive liver metastases and peritoneal carcinomatosis, suggesting the existence of a more lethal subgroup of tumors.

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Recurrence of Solid Pseudopapillary Neoplasms of the Pancreas: Results of a Nationwide Study of Risk Factors and Treatment Modalities

Irtan

Galmiche-Rolland

Elie³

et al. 2016

Pediatric Blood & Cancer

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Background Solid pseudopapillary neoplasms of the pancreas (SPPN) can relapse very late, but little is known about risk factors for recurrence and optimal treatment. We aimed to identify risk factors for recurrence and to analyze treatment modalities in all French pediatric cases of SPPN over the past 20 years. Material and methods Data were collected from pediatric oncologists and surgeons, and also from adult pancreatic surgeons in order to identify late recurrences. Results Fifty‐one patients (41 girls) were identified. Median age at diagnosis was 13.1 years [8.7–17.9]. Abdominal pain was the commonest presenting symptom (32/49, 65%). The tumor was located in the pancreatic head in 24 patients (47%). Preoperative biopsy or cytology was performed in 14 cases (28%). All patients were operated with a median of 23 days [0–163] after diagnosis. The rate of postoperative morbidity was 29%. With a median follow‐up of 65 months [0.3–221], the overall and event‐free survival was 100% and 71%, respectively. Seven patients (13.7%) relapsed with a median of 43 months [33–94] after initial surgery. Six were treated surgically, either alone (n = 3) or with perioperative chemotherapy (n = 2) or hyperthermic intraperitoneal chemotherapy (n = 1). One patient in whom further treatment was not feasible was still alive at last news. Risk factors for recurrence were positive surgical margins (P = 0.03) and age less than 13.5 years at diagnosis (P = 0.03). Conclusions SPPN recurrence in this pediatric series was a rare and late event that did not undermine overall survival. Complete surgical removal of recurrent tumors appears to be the best option.

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Peritoneal metastatic disease in a child after excision of a solid pseudopapillary tumour of the pancreas: a unique case

Abstract: We present a 15-year-old girl with peritoneal metastases from a solid pseudopapillary tumour of the pancreas, which had been excised 6 years previously. This is the third paediatric case with metastases to be reported and the fourth patient with peritoneal carcinomatosis.

Cited by 17 publications

References 7 publications

Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: report of a case

Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: report of a case

A solid pseudopapillary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential

Recurrence of Solid Pseudopapillary Neoplasms of the Pancreas: Results of a Nationwide Study of Risk Factors and Treatment Modalities

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