Peritoneal Perfusion With Oxygenated Perfluorocarbon Augments Systemic Oxygenation

Carr, Shamus R.; Cantor, Joshua P.; Rao, Atul; Lakshman, Thiru V.; Collins, Joshua E.; Friedberg, Joseph S.

doi:10.1378/chest.130.2.402

Cited by 22 publications

(13 citation statements)

References 20 publications

(17 reference statements)

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“…The OMBs used in this study were designed for high oxygen carrying capacity and rapid oxygen delivery to the peritoneum. A 70 vol% suspension of OMBs at 1.0 bar and 37 C contains an estimated 0.88 mg-O 2 mL À1 , compared to 0.31, 0.62 and 0.57 mg-O 2 mL À1 for blood, liposomal hemoglobin and pure PFC, respectively [18,20]. Furthermore, OMBs provide a greater fraction of oxygen availability to the body.…”

Section: Discussionmentioning

confidence: 99%

Systemic oxygen delivery by peritoneal perfusion of oxygen microbubbles

et al. 2014

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Severe hypoxemia refractory to pulmonary mechanical ventilation remains life-threatening in critically ill patients. Peritoneal ventilation has long been desired for extrapulmonary oxygenation owing to easy access of the peritoneal cavity for catheterization and the relative safety compared to an extracorporeal circuit. Unfortunately, prior attempts involving direct oxygen ventilation or aqueous perfusates of fluorocarbons or hemoglobin carriers have failed, leading many researchers to abandon the method. We attribute these prior failures to limited mass transfer of oxygen to the peritoneum and have designed an oxygen formulation that overcomes this limitation. Using phospholipid-coated oxygen microbubbles (OMBs), we demonstrate 100% survival for rats experiencing acute lung trauma to at least 2 h. In contrast, all untreated rats and rats treated with peritoneal oxygenated saline died within 30 min. For rats treated with OMBs, hemoglobin saturation and heart rate were at normal levels over the 2-h timeframe. Peritoneal oxygenation with OMBs was therefore shown to be safe and effective, and the method requires less equipment and technical expertise than initiating and maintaining an extracorporeal circuit. Further translation of peritoneal oxygenation with OMBs may provide therapy for acute respiratory distress syndrome arising from trauma, sepsis, pneumonia, aspiration, burns and other pulmonary diseases.

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Section: Discussionmentioning

confidence: 99%

Systemic oxygen delivery by peritoneal perfusion of oxygen microbubbles

et al. 2014

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“…Therefore, the authors assumed that the indwelling PFC served as a renewable oxygen reservoir as the animals were rendered progressively more hypoxic. 21 In the present study, we tried to introduce indwelling PFC into the thoracic cavity for a while; however, even a small volume of indwelling PFC caused cardiac dysfunction in the small animal setting. When the pressure in the thoracic cavity exceeded 10 mm H2O, the blood pressure and level of oxygenation decreased.…”

Section: Discussionmentioning

confidence: 94%

“…The reason for this may be the lack of an oxygen reservoir. In the experimental setting described by Carr et al, 21 the volume of indwelling PFC in the abdomen likely served as an oxygen reservoir and resulted in blunting of the induced hypoxia as the fraction of inspired O2 (FiO2) decreased from 18% to 10%. Therefore, the authors assumed that the indwelling PFC served as a renewable oxygen reservoir as the animals were rendered progressively more hypoxic.…”

Section: Discussionmentioning

confidence: 99%

Transpleural perfusion with oxygenated perfluorocarbon increases systemic oxygenation

Lee¹,

Cho²,

Park³

et al. 2009

Respirology

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“…Therefore, peritoneal membrane-mediated oxygenation of red blood cells is known to occur. 1,2,[11][12][13][14] Applying an appropriate method to conduct peritoneal membrane mediated oxygenation of red blood cells is important. A previous study succeeded in signifi cantly oxygenating red blood cells by the perfusion of oxygenated human red blood cells (MAP) in the peritoneal cavity of medium-sized animals (beagle dog).…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The methods and the solutions used for perfusion are important for the oxygenation of red blood cells via the peritoneal membrane.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of peritoneal oxygenation using a novel artificial oxygen carrier (TRM-645) in a rat respiratory insufficiency model

et al. 2010

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Peritoneal Perfusion With Oxygenated Perfluorocarbon Augments Systemic Oxygenation

Cited by 22 publications

References 20 publications

Systemic oxygen delivery by peritoneal perfusion of oxygen microbubbles

Systemic oxygen delivery by peritoneal perfusion of oxygen microbubbles

Transpleural perfusion with oxygenated perfluorocarbon increases systemic oxygenation

Efficacy of peritoneal oxygenation using a novel artificial oxygen carrier (TRM-645) in a rat respiratory insufficiency model

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