Peritoneal retention of liposomes: Effects of lipid composition, PEG coating and liposome charge

Dadashzadeh, Simin; Mirahmadi, N.; Babaei, Mohammad Hosein; Vali, A.M.

doi:10.1016/j.jconrel.2010.08.026

Cited by 103 publications

(69 citation statements)

References 39 publications

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“…Combining DSPG with DOPC and DSPC lipids led to PEGylated formulations with similar (sample 5; 70.4 nm) or statistically lower (sample 6; 121.3 nm) mean particle sizes compared to the conventional samples (sample 2 and 3 respectively). These results agree with the observations from the PEGylated drug-free formulations (samples 4e, 5e and 6e) as well as with similar papers in the literature [40], confirming the superiority of PEGylated formulations over conventional ones. bilayer.…”

Section: Liposome Characterizationsupporting

confidence: 92%

“…The addition of DSPG had different impacts on particle size distribution, depending on the type of lipid that it was combined with. Similar results arose from the corresponding formulations without the drug (samples 1e, 2e and 3e), as well as from other published studies [40]. Furthermore, it was reported that the ionic strength of the mixture during the formation of liposomes might influence their mean diameter in the presence of charged lipid components.…”

Section: Liposome Characterizationsupporting

confidence: 89%

“…The addition of DSPG to DOPC and DSPC lipids formed shikonin-loaded conventional liposomes with statistically increased ζ-potential values (-19.9 and -16.2 mV, respectively). This could be due to the fact that DSPG is a negatively charged lipid, adding an additional charge in the lipid bilayer [40,48]. In addition, DOPC/DSPG liposomes (sample 2) seemed to have an advantage regarding their ζ-potential values, compared to DSPC/DSPG (sample 3).…”

Section: ζ-Potentialmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Tsermentseli

Kontogiannopoulos

Papageorgiou

et al. 2018

Fluids

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Abstract:Liposomes are considered to be one of the most successful drug delivery systems.They apply nanotechnology to potentiate the therapeutic efficacy and reduce the toxicity of conventional medicines. Shikonin and alkannin, a pair of chiral natural naphthoquinone compounds, derived from Alkanna and Lithospermum species, are widely used due to their various pharmacological activities, mainly wound healing, antioxidant, anti-inflammatory and their recently established antitumor activity. The purpose of this study was to prepare conventional and PEGylated shikonin-loaded liposomal formulations and measure the effects of different lipids and polyethylene glycol (PEG) on parameters related to particle size distribution, the polydispersity index, the zeta potential, drug-loading efficiency and the stability of the prepared formulations. Three types of lipids were assessed (1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DSPG)), separately and in mixtures, forming anionic liposomes with good physicochemical characteristics, high entrapment efficiencies (varying from 56.5 to 89.4%), satisfactory in vitro release profiles and good physical stability. The addition of the negatively charged DSPG lipids to DOPC, led to an increment in the drug's incorporation efficiency and reduced the particle size distribution. Furthermore, the shikonin-loaded PEGylated sample with DOPC/DSPG, demonstrated the most satisfactory characteristics. These findings are considered promising and could be used for further design and improvement of such formulations.

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Section: Liposome Characterizationsupporting

confidence: 92%

Section: Liposome Characterizationsupporting

confidence: 89%

Section: ζ-Potentialmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Tsermentseli

Kontogiannopoulos

Papageorgiou

et al. 2018

Fluids

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“…Taking into account the clearance rate of nanoparticles from the IP cavity, such a controlled release system can be tuned so that a constant amount of nanoparticles is present in the IP cavity. It should be noted that a good retention time in the peritoneal cavity was reported for 100 nm positively charged liposomes by Dadashzadeh et al [58]. The size of the liposomes upon IP administration was however not continuously monitored.…”

Section: Tailoring Delivery Systems For Ip Therapymentioning

confidence: 97%

Colloidal stability of nano-sized particles in the peritoneal fluid: Towards optimizing drug delivery systems for intraperitoneal therapy

et al. 2014

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Intraperitoneal (IP) administration of nano-sized delivery vehicles containing small interfering RNA (siRNA) is recently gaining attention as an alternative route for the efficient treatment of peritoneal carcinomatosis. The colloidal stability of nanomatter following IP administration has, however, not been thoroughly investigated yet. Here, enabled by advanced microscopy methods such as Single Particle Tracking (SPT) and Fluorescence Correlation Spectroscopy (FCS), we follow the aggregation and cargo release of nano-scaled systems directly in peritoneal fluids from healthy mice and ascites fluid from a patient diagnosed with peritoneal carcinomatosis. The colloidal stability in the peritoneal fluids was systematically studied in function of the charge (positive or negative) and Poly-Ethylene Glycol (PEG) degree of liposomes and polystyrene nanoparticles, and compared to human serum. Our data demonstrate strong aggregation of cationic and anionic nanoparticles in the peritoneal fluids, while only slight aggregation was observed for the PEGylated ones. PEGylated liposomes, however, lead to a fast and premature release of siRNA cargo in the peritoneal fluids. Based on our observations, we reflect on how to tailor improved delivery systems for IP therapy.

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“…Dadashzadeh et al, however, looked into the effect of size, charge, lipid composition and PEG coating on peritoneal retention in healthy female NMRI mice using 100 nm and 1000 nm radiolabeled liposomes [66]. The charge of the liposomes seemed to be the most important factor that determined the retention in the abdominal cavity, with cationic liposomes being longer retained than negatively charged liposomes.…”

Section: Biodistribution Of Nps Following Ip Injectionmentioning

confidence: 99%

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

Dakwar

Shariati

Willaert

et al. 2017

Advanced Drug Delivery Reviews

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Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal carcinomatosis (PC). Over the past decade, a lot of effort has been put both in the academia and clinic in developing IP therapeutic approaches that maximize local efficacy while limiting systemic side effects. Also nanomedicines are under investigation for the treatment of tumors confined to the peritoneal cavity, due to their potential to increase the peritoneal retention and to target drugs to the tumor sites as compared to free drugs. Despite the progress reported by multiple clinical studies, there are no FDA approved drugs or formulations for specific use in the IP cavity yet. This review discusses the current clinical management of PC, as well as recent advances in nanomedicines-based IP delivery.We address important challenges to be overcome towards designing optimal nanocarriers for IP therapy in vivo.

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Peritoneal retention of liposomes: Effects of lipid composition, PEG coating and liposome charge

Cited by 103 publications

References 39 publications

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Colloidal stability of nano-sized particles in the peritoneal fluid: Towards optimizing drug delivery systems for intraperitoneal therapy

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

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