Peritonitis caused by <i><scp>B</scp>lastomyces dermatitidis</i> in a kidney transplant recipient: case report and literature review

Barocas, Joshua A.; Gauthier, Gregory M.

doi:10.1111/tid.12234

Cited by 11 publications

(14 citation statements)

References 33 publications

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“…B. dermatitidis can infect nearly every organ of the body including the eye, endocrine glands, muscles, peritoneum, and breast. 82,83 It is because of the great variety of clinical manifestations that B. dermatitidis infection has been called "the great pretender." As noted previously, more than half of infected patients are asymptomatic.…”

Section: Clinical Presentation Of Human Diseasementioning

confidence: 99%

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New Developments in Blastomycosis

Smith

Gauthier

2015

Semin Respir Crit Care Med

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Blastomyces dermatitidis, the etiologic agent of blastomycosis, is a thermally dimorphic fungus that grows as a filamentous mold in the environment and as budding yeast in human tissue. This pathogen is endemic to North America, particularly in the states bordering the Mississippi and Ohio rivers, the Great Lakes, and the St. Lawrence Seaway. Infection with B. dermatitidis causes a broad array of clinical manifestations ranging from asymptomatic infection to fulminant sepsis with acute respiratory distress syndrome and death. B. dermatitidis can infect almost any organ in the body, but has a predilection for lungs and skin. There have been recent advances in the understanding of the pathogenesis, diagnosis, and treatment of this fungus. The Infectious Diseases Society of America published updated guidelines in 2008 to guide clinicians in the treatment of this important pathogen.

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Section: Clinical Presentation Of Human Diseasementioning

confidence: 99%

“…Tubo-ovarian abscesses can be complicated by extension of B. dermatitidis into the abdominopelvic cavity resulting peritoneal and omental nodules along with new onset ascites. 83…”

Section: Osseous Blastomycosismentioning

confidence: 99%

New Developments in Blastomycosis

Smith

Gauthier

2015

Semin Respir Crit Care Med

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“…Thirty-one cases of blastomycosis were reported [ 7 , 8 , 13 , 20 , 21 , 23 , 35 , 45 , 46 , 48 , 51 , 52 , 55 , 59 , 60 , 64 , 65 , 67 , 68 , 70 , 195 , 209 , 211 , 244 ]. The majority of reports from the United States (10 of 16) were within endemic areas [ 20 , 21 , 35 , 45 , 46 , 51 , 60 , 67 , 195 , 211 ].…”

Section: Resultsmentioning

confidence: 99%

Clinical Characteristics and Outcomes of Endemic Mycoses After Solid Organ Transplantation: A Comprehensive Review

Abad,

Razonable

2024

Open Forum Infectious Diseases

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Background Geographically endemic fungi can cause significant disease among solid organ transplant (SOT) recipients. We provide an update on the epidemiology, clinical presentation and outcomes of 5 endemic mycoses in SOT recipients. Methods Multiple databases were reviewed from inception through May 2023 using key words for endemic fungi (e.g. Coccidioidomycosis or Coccidioides, Histoplasmosis or histoplasma, etc.). We included adult SOT recipients and publications in English or with English translation. Results Among 16 cohort studies that reported on blastomycosis (n=3), coccidioidomycosis (n=5), histoplasmosis (n=4), and various endemic mycoses (n=4), the incidence rates varied: coccidioidomycosis (1.2-5.8%); blastomycosis (0.14-0.99%) and histoplasmosis (0.4-1.1%). There were 204 reports that described 268 unique cases of endemic mycoses, including 172 histoplasmosis, 31 blastomycosis, 34 coccidioidomycosis, 6 paracoccidioidomycosis, and 25 talaromycosis. The majority of patients were male (176/261, 67.4%). Transplanted allografts were mostly kidney (191/268, 71.3%), followed by liver (n=39, 14.6%), heart (n=18, 6.7%), lung (n=13, 4.9%), combined kidney-liver, and kidney-pancreas (n=6, 2.7%). In all five endemic mycoses, most patients presented with fever (162/232, 69.8%) and disseminated disease (179/268, 66.8%). Cytopenias were frequently reported for histoplasmosis (71/91, 78.0%), coccidioidomycosis (8/11, 72.7%) and talaromycosis (7/8, 87.5%). Graft loss was reported in 12/136 patients (8.8%). All-cause mortality was reported in 71/267 (26.6%); half (n=34, 50%) of the deaths were related to the underlying mycoses. Conclusions Endemic mycoses commonly present with fever, cytopenias and disseminated disease in SOT recipients. There is a relatively high rate of all-cause mortality, including many that were attributed to endemic mycoses.

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“…On review of 11 reported cases of blastomycotic peritonitis, six had definite pneumonia and three had antecedent pulmonary infection (pleural thickening, pleural effusion) . Blastomyces peritonitis has also been reported in a kidney transplant recipient …”

Section: Discussionmentioning

confidence: 99%

Blastomyces dermatitidis peritonitis complicating peritoneal dialysis

Sanghvi

Somers

2017

Seminars in Dialysis

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Fungal peritonitis is an uncommon complication in peritoneal dialysis patients. We report a case of blastomyces dermatitis peritonitis in a nonimmunocompromised peritoneal dialysis patient, who initially presented with symptoms of lower extremity weakness and altered mental status. Peritoneal blastomycosis is rare condition and not previously reported in end stage renal disease patients on peritoneal dialysis. Fungal peritonitis can present with subtle clinical findings so a high index of suspicion is needed as early detection and treatment may decrease mortality and morbidity.

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Peritonitis caused by Blastomyces dermatitidis in a kidney transplant recipient: case report and literature review

Cited by 11 publications

References 33 publications

New Developments in Blastomycosis

New Developments in Blastomycosis

Clinical Characteristics and Outcomes of Endemic Mycoses After Solid Organ Transplantation: A Comprehensive Review

Blastomyces dermatitidis peritonitis complicating peritoneal dialysis

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