2014
DOI: 10.1111/bjd.13100
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Peritumoral indoleamine 2,3‐dioxygenase expression in melanoma: an early marker of resistance to immune control?

Abstract: Endothelial IDO expression is highly consistent in primary, sentinel and metastatic tissues of patients with melanoma, indicating that immune suppression in melanoma is determined very early in the disease course. This supports that IDO expression in melanoma is a marker of antitumour immune response with an independent prognostic value.

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Cited by 56 publications
(70 citation statements)
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“…This clustering of IDO expression in the sentinel and in PBMCs is remarkable, as we previously showed that IDO expression is also consistent in the primary, sentinel, and even metastatic tissue of melanoma patients. 8 Our results indicate that IDO expression by host cells is important in the pathogenesis of melanoma, but the question remains how this IDO expression is induced. Soluble tumorderived factors could be responsible, but alternatively this clustering could also indicate a certain patient-related predisposition.…”
Section: Discussionmentioning
confidence: 75%
See 3 more Smart Citations
“…This clustering of IDO expression in the sentinel and in PBMCs is remarkable, as we previously showed that IDO expression is also consistent in the primary, sentinel, and even metastatic tissue of melanoma patients. 8 Our results indicate that IDO expression by host cells is important in the pathogenesis of melanoma, but the question remains how this IDO expression is induced. Soluble tumorderived factors could be responsible, but alternatively this clustering could also indicate a certain patient-related predisposition.…”
Section: Discussionmentioning
confidence: 75%
“…Therefore, the sentinel lymph nodes of the included patients were immunohistochemically stained for IDO and assessed as previously reported. 8 Remarkably, patients with an IDO-positive sentinel had more circulating IDO-positive PBMCs (cultured, unstimulated cells, p D 0.016). This could be attributed to higher levels of IDOC mMDSCs ( Table 5, lower part), which were found to be associated with IDO status of the sentinel (p D 0.018).…”
Section: Pd-l1mentioning
confidence: 96%
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“…They observed better OS (p = 0.04) in patients who demonstrated elevated expression of IDO in both the primary tumors and lymph nodes, independently. Worth noticing is the fact that the better prognosis of patients with lower nodal IDO expression was independent of whether the nodes were metastatic or not [14]. Speckaert et al analyzed 116 sentinel lymph nodes from melanoma patients using IHC and flow cytometry.…”
Section: Discussionmentioning
confidence: 99%