Periurethral Fibrosis Secondary to Prostatic Inflammation Causing Lower Urinary Tract Symptoms: A Prospective Cohort Study

Prostatic Inflammation Induces Fibrosis in a Mouse Model of Chronic Bacterial Infection

“…There is accumulating evidence for the contribution of increased collagen deposition and fibrosis to the pathogenesis of BPH/LUTS [3]–[5], [62]; however, the underlying cause of increased collagen deposition in this common aging-related disease has not been elucidated. Experimental studies have observed a potential link between inflammation and extracellular matrix alterations in the prostate in both in vitro and in vivo studies.…”

“…A recent study by Cantiello and colleagues, for example, showed that human prostate samples with evidence of inflammation had a significantly greater collagen content than those without inflammation [5]. However, a causal relationship between inflammation and fibrosis of the prostate has never been established.…”

Is Periurethral Calcification Associated With Urinary Flow Rate and Symptom Severity in Men With Lower Urinary Tract Symptoms-Benign Prostatic Hyperplasia? A Retrospective Review

“…On the basis of these studies, it can be assumed that periurethral fibrosis can be a cause of LUTS through decreased urethral flexibility while compromising the ability of the prostatic urethra to enlarge to adequately accommodate urinary flow during micturition. 7 When fibrosis occurs, tissue stiffness results from myofibroblast accumulation, collagen deposition, and extracellular matrix remodeling. 6 Numerous studies have shown that fibrotic changes induced by aging and inflammation contribute to dysfunction and disease in multiple organ systems, especially in gastrointestinal and pulmonary organs.…”

Androgen Deficiency and Progression of Benign Prostatic Hyperplasia in Patients With Metabolic Syndrome: Is There Any Controversy? (A Literature Review)

“…Длительно текущее воспаление у больных с МС ведет не только к усилению СНМП, но также к мор-фологическим изменениям в мочевом пузыре, включая фиброз (сниженное отношение мышцы / соединитель-ная ткань), лейкоцитарную инфильтрацию, вызванную гипоксией, и экспрессию маркеров воспаления [51,68]. При гистологическом исследовании периуретральной части ПЖ выявили более выраженный фиброз у паци-ентов с МС по сравнению с больными, не имеющими этих метаболических нарушений, и сделали заключе-ние, что выраженный периуретральный фиброз, раз-вившийся вследствие хронического воспаления у этих больных, может быть причиной формирования СНМП вследствие утраты эластичности уретры.…”