Perivenular Fibrosis as Precursor Lesion of Cirrhosis

Worner, Theresa M.; Lieber, Charles S.

doi:10.1001/jama.1985.03360050065027

Cited by 158 publications

(58 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fibrous extension is also a histological feature associated with thickened central veins in the liver of patients with alcoholic hepatitis (Chevallier et al, 1994). We found that 49.2% of elderly cadaveric livers had CVF, comparable with the 44% incidence found in young adult heavy alcohol drinkers, aged 47.6 AE 3.1 years (Worner and Lieber, 1985). Sequential biopsies conducted by these investigators revealed that alcoholics with CVF in early stages of fatty liver are more susceptible to progression to more severe stages of fibrosis and ultimately cirrhosis.…”

Section: Discussionsupporting

confidence: 78%

Hepatic Steatosis, Fibrosis, and Cancer in Elderly Cadavers

Mak

Kwong

Chu

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

The incidence of hepatic steatosis, fibrosis, and cancer in the elderly population remains unknown. Human cadavers used in anatomy teaching, which come largely from older adults, may provide liver tissue for examining their pathologies. Livers were obtained from 68 cadavers (mean age 82.1 ± 10.4 years) with diverse causes of death in the Anatomy course at Mount Sinai School of Medicine. Paraffin sections were stained with hematoxylin and eosin and Sirius red and evaluated for steatosis, fibrosis, cancer, and lipofuscin. Tissue preservation was graded as good in 38.2% of the embalmed livers, fair in 36.7%, and poor in 25.0%. Steatosis was observed in 35.3% of the livers, central vein fibrosis in 49.2%, perisinusoidal fibrosis in 63.2%, portal tract (PT) fibrosis in 47.0%, septa formation in 44.1%, bridging fibrosis in 30.8%, and cirrhosis in 4.4%. One hepatocellular carcinoma (HCC) and six metastatic tumors were detected. Lobular inflammation occurred in 20.8% of the livers and PT inflammation in 38.8%. Nine livers showed minimal change. Lipofuscin was detected in 60.2% of the livers. Steatosis, fibrosis, and cancer are highly prevalent in elderly cadavers with diverse causes of death. The prevalence of steatosis and fibrosis is consistent with the data in patients with specific liver diseases. Steatosis alongside fibrosis can accelerate the progression of fibrosis to cirrhosis and ultimately HCC. Though not indicated as the primary cause of death, the liver injury may have compromised hepatic functions and enhanced disease susceptibility, thereby exacerbating the health conditions in this elderly population. Anat Rec, 2012. © 2011 Wiley Periodicals, Inc.

show abstract

Section: Discussionsupporting

confidence: 78%

Hepatic Steatosis, Fibrosis, and Cancer in Elderly Cadavers

Mak

Kwong

Chu

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…Moreover, we have shown for the first time that recurrence of alcoholic hepatitis is a common event in patients with alcoholic hepatitis on the It has been reported that patients with perivenular fibrosis show rapid fibrosis progression. 14,15,18 However, the importance of perivenular fibrosis in the pathogenesis of alcohol-induced liver injury remains unknown, as studies evaluating this lesion were performed on a small cohort and multivariate analysis was not performed. In the present study, perivenular fibrosis did not predict fibrosis progression, as the trend towards significance in univariate analysis disappeared in multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…12 In alcoholic liver disease, studies using a design of repeated biopsies have provided valuable information, [13][14][15][16][17][18] and suggest steatosis as a risk factor for development of cirrhosis. 17 However, in those studies, the number of patients with repeated liver biopsies, ranging from 16 out of 76 19 to 39 out of 88 17 was not sufficient to determine the evolution of patients according to their initial histological diagnosis.…”

mentioning

confidence: 99%

“…17 In addition to steatosis, controversy remains concerning the influence of perivenular fibrosis on progression to liver fibrosis. 14,15,18,20 Conversely, the major impact of alcoholic hepatitis on subsequent development of cirrhosis has been clearly established. 9,11,13,16,19 However, whether exacerbation of fibrosis progression occurs after the initial episode of alcoholic hepatitis or is related to the development of multiple episodes of alcoholic hepatitis during alcohol consumption remains unknown.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features

Mathurin

Beuzin

Louvet

et al. 2007

Aliment Pharmacol Ther

129

View full text Add to dashboard Cite

show abstract

“…1,2 Acetaldehyde, a potential prothe development of liver fibrosis. We have studied the oxidant factor linked to ethanol metabolism, has been proeffect of neutrophil-derived reactive oxygen species posed as a mediator of fibrogenesis in alcoholic liver disease.…”

mentioning

confidence: 99%

Neutrophil–Derived Superoxide Anion Induces Lipid Peroxidation and Stimulates Collagen Synthesis in Human Hepatic Stellate Cells: Role of Nitric Oxide

et al. 1997

View full text Add to dashboard Cite

Hepatic fibrosis is the main histological feature that accomExperimental evidence indicates that the lipid peroxipanies the progression of alcoholic liver injury to cirrhosis dation of biological membranes is often associated with in chronic alcohol abusers. 1,2 Acetaldehyde, a potential prothe development of liver fibrosis. We have studied the oxidant factor linked to ethanol metabolism, has been proeffect of neutrophil-derived reactive oxygen species posed as a mediator of fibrogenesis in alcoholic liver disease. (ROS) on collagen synthesis by human hepatic stellateIn fact, an immunohistochemical association between acetalcells (HSC), the major source of collagen in the liver, in dehyde-protein adducts and extracellular matrix deposition a coculture system. Lipid peroxidation in the cocultures in alcohol-induced liver injury has been reported. of extracellular matrix components in the liver. 6,13-16 When ROS resulted in the early induction of lipid peroxidation isolated and cultured on plastic, they undergo spontaneous and was associated with a marked increase (threefold) transformation into myofibroblast-like cells, thereby mimickof procollagen I mRNA expression and synthesis. The ing in vitro 17 conditions that prevail in vivo after chronic addition of antioxidants, such as vitamin E or superoxalcohol consumption. [18][19][20] However, different mechanisms, ide dismutase (SOD), impaired this stimulation. The other than acetaldehyde-induced fibrogenesis, may be ininhibition of neutrophil NO formation by N G -monovolved in alcoholic hepatic fibrosis. Evidence coming from methyl-L-arginine made the ROS-induced stimulation of either experimental or clinical studies indicates that lipid procollagen I more evident. The addition of xanthine/ peroxidation of biological membranes is often associated with xanthine oxidase X/XO, a superoxide anion donor, to the development of liver fibrosis. [21][22][23][24][25] We have recently shown HSC cultures strongly increased procollagen I synthesis.that the induction of lipid peroxidation phenomena or that This stimulation was hampered by the addition of both treatment with 4-hydroxynonenal (a highly reactive alde-SOD and sodium nitroprusside (an NO donor). The conhydic end-product of lipid peroxidation) stimulates procollatribution of HSC to the production of NO in our coculgen type I synthesis in human HSC by acting at the level ture system was negligible, because inducible NO synof gene expression. 26 Moreover, malondialdehyde has been thase (iNOS) mRNA was almost undetectable in these shown to stimulate collagen production by rat HSC upon acticells, and also because the amount of NO produced by vation in primary culture. 27 HSC stimulated with tumor necrosis factor a (TNF-a)Although alcoholic liver fibrosis may develop in the absence and lipopolysaccharide (LPS) was 500 times less than of evident inflammation, 1,2 the occurrence of alcoholic hepatithat synthesized by neutrophils. In conclusion, these retis may contribute to the increased extracellular matrix deposults ind...

show abstract

Perivenular Fibrosis as Precursor Lesion of Cirrhosis

Cited by 158 publications

References 18 publications

Hepatic Steatosis, Fibrosis, and Cancer in Elderly Cadavers

Hepatic Steatosis, Fibrosis, and Cancer in Elderly Cadavers

Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features

Neutrophil–Derived Superoxide Anion Induces Lipid Peroxidation and Stimulates Collagen Synthesis in Human Hepatic Stellate Cells: Role of Nitric Oxide

Contact Info

Product

Resources

About