Perlecan participates in proliferation activation of quiescent <i>Drosophila</i> neuroblasts

Voigt, Aaron; Pflanz, Ralf; Schäfer, Ulrich; Jäckle, Herbert

doi:10.1002/dvdy.10120

Cited by 117 publications

(117 citation statements)

References 63 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Four genes within the QTL region and two just outside it are similar to genes with roles in neurogenesis. Of the latter, trol (terribly reduced optic lobes, also called perlecan) is a large multidomain heparan sulfate proteoglycan in the extracellular matrix with Laminin G domains that binds to and stores other signaling molecules controlling neuroblast proliferation (43). On the other side of the QTL region is CCR4-Not, coding for the catalytic subunit of the deadenylase complex (44,45), which interacts with the conserved P body component HPat/Pat1 to regulate synaptic terminal growth in the Drosophila neuromuscular junction (46).…”

Section: Discussionmentioning

confidence: 99%

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

Koutroumpa

Groot

Dekker

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The sexual pheromone communication system of moths is a model system for studies of the evolution of reproductive isolation. Females emit a blend of volatile components that males detect at a distance. Species differences in female pheromone composition and male response directly reinforce reproductive isolation in nature, because even slight variations in the species-specific pheromone blend are usually rejected by the male. The mechanisms by which a new pheromone signal-response system could evolve are enigmatic, because any deviation from the optimally attractive blend should be selected against. Here we investigate the genetic mechanisms enabling a switch in male response. We used a quantitative trait locus-mapping approach to identify the genetic basis of male response in the two pheromone races of the European corn borer, Ostrinia nubilalis. Male response to a 99:1 vs. a 3:97 ratio of the E and Z isomers of the female pheromone is governed by a single, sex-linked locus. We found that the chromosomal region most tightly linked to this locus contains genes involved in neurogenesis but, in accordance with an earlier study, does not contain the odorant receptors expressed in the male antenna that detect the pheromone. This finding implies that differences in the development of neuronal pathways conveying information from the antenna, not differences in pheromone detection by the odorant receptors, are primarily responsible for the behavioral response differences among the males in this system. Comparison with other moth species reveals a previously unexplored mechanism by which male pheromone response can change in evolution.Ostrinia nubilalis | Z chromosome | pheromone response | sexual communication | QTL analysis

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

Koutroumpa

Groot

Dekker

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Alternatively, the primary role of glial innexins might be in transfer of signals from these cells to developing neurons. The former is an attractive hypothesis because glial cells are known to regulate neuronal development through provision of signalling molecules including Anachronism and Perlecan (Ebens et al, 1993;Caldwell and Datta, 1998;Park et al, 2001;Voigt et al, 2002), E-cadherin (Dumstrei et al, 2003) and TGF-b family member Myoglianin (Awasaki et al, 2011). However, both scenarios are possible, and distinguishing these are key questions for future studies.…”

Section: Ogre and Inx2 Are Expressed In Neural Precursors And Glial Cmentioning

confidence: 99%

Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous system

Holcroft

Jackson

Lin

et al. 2013

Journal of Cell Science

View full text Add to dashboard Cite

SummaryInnexins are one of two gene families that have evolved to permit neighbouring cells in multicellular systems to communicate directly. Innexins are found in prechordates and persist in small numbers in chordates as divergent sequences termed pannexins. Connexins are functionally analogous proteins exclusive to chordates. Members of these two families of proteins form intercellular channels, assemblies of which constitute gap junctions. Each intercellular channel is a composite of two hemichannels, one from each of two apposed cells. Hemichannels dock in the extracellular space to form a complete channel with a central aqueous pore that regulates the cell-cell exchange of ions and small signalling molecules. Hemichannels can also act independently by releasing paracrine signalling molecules. optic ganglion reduced (ogre) is a member of the Drosophila innexin family, originally identified as a gene essential for postembryonic neurogenesis. Here we demonstrate, by heterologous expression in paired Xenopus oocytes, that Ogre alone does not form homotypic gap-junction channels; however, co-expression of Ogre with Innexin2 (Inx2) induces formation of functional channels with properties distinct from Inx2 homotypic channels. In the Drosophila larval central nervous system, we find that Inx2 partially colocalises with Ogre in proliferative neuroepithelia and in glial cells. Downregulation of either ogre or inx2 selectively in glia, by targeted expression of RNA interference transgenes, leads to a significant reduction in the size of the larval nervous system and behavioural defects in surviving adults. We conclude that these innexins are crucially required in glial cells for normal postembryonic development of the central nervous system.

show abstract

“…trol encodes Drosophila Perlecan, a heparan sulphate proteoglycan ( Voigt et al 2002;Park et al 2003). In mammals, Perlecan is a component of basal membranes that interacts with other extracellular matrix proteins, growth factors and receptors, to regulate cellular signalling ( Voigt et al 2002;Park et al 2003).…”

Section: (D) Neuroblast Reactivationmentioning

confidence: 99%

Insights into neural stem cell biology from flies

Egger

Chell

Brand

2007

Phil. Trans. R. Soc. B

134

126

View full text Add to dashboard Cite

Drosophila neuroblasts are similar to mammalian neural stem cells in their ability to self-renew and to produce many different types of neurons and glial cells. In the past two decades, great advances have been made in understanding the molecular mechanisms underlying embryonic neuroblast formation, the establishment of cell polarity and the temporal regulation of cell fate. It is now a challenge to connect, at the molecular level, the different cell biological events underlying the transition from neural stem cell maintenance to differentiation. Progress has also been made in understanding the later stages of development, when neuroblasts become mitotically inactive, or quiescent, and are then reactivated postembryonically to generate the neurons that make up the adult nervous system. The ability to manipulate the steps leading from quiescence to proliferation and from proliferation to differentiation will have a major impact on the treatment of neurological injury and neurodegenerative disease.

show abstract

Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts

Cited by 117 publications

References 63 publications

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

Genetic mapping of male pheromone response in the European corn borer identifies candidate genes regulating neurogenesis

Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous system

Insights into neural stem cell biology from flies

Contact Info

Product

Resources

About