Permanence of Retrograde Amnesia Produced by Electroconvulsive Shock

Luttges, Marvin W.; McGaugh, James L.

doi:10.1126/science.156.3773.408

Cited by 99 publications

(49 citation statements)

References 9 publications

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“…Experimental procedures usually include a singletrial avoidance task followed by amnestic treatments (e.g., electroconvulsive shock) at various intervals after training. Results from early experiments revealed that memories were susceptible to being disrupted within 1 to 3 hours after training (depending on shock intensity), and would not be affected if treatments were administered outside this window (McGaugh, 1966;Luttges & McGaugh, 1967).…”

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Neutral mood induction during reconsolidation reduces accuracy, but not vividness and anxiety of emotional episodic memories

Liu

McNally

2017

Journal of Behavior Therapy and Experimental Psychiatry

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When consolidated memories are reactivated, they become labile and have to go through reconsolidation to become stabilized. This property of memory may potentially be used to reduce the impact of highly negative episodic memories. Because detailed and vivid negative episodic memories are mediated by high arousal, if arousal is lessened during reconsolidation, then memory accuracy and vividness should diminish. In this study, I examine this hypothesis. Participants viewed a stressful, suspenseful movie on My English teacher, Stefanie Morejon, helped organize a film screening to test the movie clips to be used in the experiment. I appreciate her help.Cynthia Tsai, and Avia Tadmor, the two former thesis writers whose research topic was similar to mine, generously shared their notes, theses, and experimental materials with me. Their wholehearted support is highly appreciated. I would also like to thank Winnie Wu for sharing her ALM thesis proposal.I would like to thank

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confidence: 99%

Neutral mood induction during reconsolidation reduces accuracy, but not vividness and anxiety of emotional episodic memories

Liu

McNally

2017

Journal of Behavior Therapy and Experimental Psychiatry

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“…Zinkin & Miller (1967) found that in a step-down apparatus with rats, recovery from amnesia observed at 24 h occurred if the animals were given additional reinforced trials at 48 and 72 h. Luttges & McGaugh (1967) found this not to be true for mice using a step-through apparatus.…”

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Electroconvulsive shock induced amnesia and recovery

Geller

Jarvik

1968

Psychon Sci

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Electroconvulsive shock induced amnesia and recovery IRecovery from electroconvulsive shock (ECS) induced amnesia in mice did not occur with time alone or with multiple trials in a step through apparatus, although attempts were made to increase the probability of such recovery. Subjects receiving foot shock (FS) and ECS always show significantly higher latencies than unshocked controls and this difference can be increased using a threshold FS after extinction.

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“…As explained traditionally by the concept of memory consolidation, RA results from a failure of memory storage (see, e.g., Jacobs & Sorenson, 1969;Riccio, Hodges, & Randall, 1968;Spanis & Squire, 1987), and it has been thought by many researchers to be permanent (e.g., King & Glasser, 1970;Luttges & McGaugh, 1967). However, increasing numbers of studies continue to demonstrate that animals are able to recover memories thought to be lost permanently due to the amnesic treatment (see Riccio & Richardson , 1984, for a review).…”

Section: Hypothermia-induced Retrograde Amnesia In Young and Adult Swmentioning

confidence: 99%

Hypothermia-induced retrograde amnesia in young and adult Swiss mice

Nagy

Martin

1993

Bull. Psychon. Soc.

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To determine whether young and adult mice were capable of recovery from hypothermia-induced retrograde amnesia, mice at 16, 25, and 100 days of age received shock for crossing from a white to a black chamber in a one-trial passive avoidance paradigm. An equal number of mice at each age received no shock for making the crossover response. Following training, half the mice in each training group received exposure to hypothermia by immersion to the neck in a cold water bath, and the remaining half were suspended over an empty water bath. All mice were given one additional daily trial for the next 6 days in the avoidance chamber, but shock was never presented. The results indicated that both young and old mice were rendered equally amnestic by the hypothermia treatment. In addition, there was no evidence of recovery from the retrograde amnesia at any age. Possible reasons for the failure to obtain recovery are discussed.

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Permanence of Retrograde Amnesia Produced by Electroconvulsive Shock

Cited by 99 publications

References 9 publications

Neutral mood induction during reconsolidation reduces accuracy, but not vividness and anxiety of emotional episodic memories

Neutral mood induction during reconsolidation reduces accuracy, but not vividness and anxiety of emotional episodic memories

Electroconvulsive shock induced amnesia and recovery

Hypothermia-induced retrograde amnesia in young and adult Swiss mice

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