Permanent, 3-stage, 4-vessel occlusion as a model of chronic and progressive brain hypoperfusion in rats: a neurohistological and behavioral analysis

Neto, Carolina Justus Buhrer Ferreira; Paganelli, Ricardo Alexandre; Benetoli, Arcélio; Lima, Keli Carina Miltus; Milani, Humberto

doi:10.1016/j.bbr.2004.12.016

Cited by 30 publications

(31 citation statements)

References 30 publications

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“…The 2-vessel occlusion (2-VO) young rat model is used to reproduce neuropathological and behavioral changes consistent with those observed in VCID patients. Permanent occlusion of bilateral common carotid arteries leads to early CBF reductions, approximately 66 % in the cortex and 48 % in the hippocampus after 2.5 h (Neto et al 2005). However, CBF can be restored 35 % in the cortex and 26 % in the hippocampus one week later.…”

Section: Cerebral Hypoperfusionmentioning

confidence: 96%

“…However, nine weeks after 3-VO, pyramidal neuronal damage was absent or significantly reduced (5 %). This suggests a time-dependent recovery from neuronal damage in the 2-and 3-VO models (Neto et al 2005).…”

Section: Cerebral Hypoperfusionmentioning

confidence: 98%

“…Therefore, this model results in consistent and uniform CA1 pyramidal cell loss, in addition to learning and memory deficits. Time course and magnitude of these changes are highly dependent on whether the CCA or ICA was occluded (Neto et al 2005;Pereira et al 2012).…”

Section: Cerebral Hypoperfusionmentioning

confidence: 99%

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Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Gooch

Wilcock

2016

Cell Mol Neurobiol

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Although SHRSP develop severe hypertension, milder chronic hypertension is induced by supplementing drinking water with the NOS-inhibitor L-N-Nitroarginine methyl ester, 39 or chronic infusion of angiotensin II by minipump. 40 Mice receiving a subpressor infusion of angiotensin II develop mild hypertension (mean arterial blood pressure 90 mm Hg, relative to 70 mm Hg in saline-infused controls). 40 In addition to vascular actions, subpressor concentrations of the hyper-tensive agent may have direct effects on neural organization and metabolism. Hyperhomocysteinemia in Mice and Rats Elevated plasma concentration of the nonessential amino acid homocysteine, termed hyperhomocysteinemia, is a risk factor for VCID. 41 In wild-type mice, a diet deficient in 3 B vitamins (B6, B9-folate, and B12) resulted in hyperhomocysteinemia within 10 weeks, accompanied by reduced capillary density in brain tissue and impaired performance in Morris water maze.

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Section: Cerebral Hypoperfusionmentioning

confidence: 96%

Section: Cerebral Hypoperfusionmentioning

confidence: 98%

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Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Gooch

Wilcock

2016

Cell Mol Neurobiol

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“…Recently, a multistage carotid occlusion technique was evaluated as a hypoperfusion model in rats, and this study showed similar effects. Within 4 weeks, persistent cognitive impairment was established, and only 49 days later, hippocampal neuronal loss was seen [125].…”

Section: Microembolismmentioning

confidence: 98%

Chronic Ischemia and Neurocognition

Chmayssani

Festa

Marshall

2007

Neuroimaging Clinics of North America

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“…A persistent decrease in regional cerebral flow leads to memory impairment and further contributes to the progression of dementia [42,43] . The permanent and bilateral occlusion of the common carotid arteries of rats is widely used as an appropriate experimental procedure to model chronic cerebral hypoperfusion and for the development of neuroprotective strategies [44,45] . The blood flow reduction by BCCAO leads to a deficiency of oxygen and nutrients in the brain, which causes energy depletion and an accumulation of extracellular glutamate level in the neurons.…”

Section: Discussionmentioning

confidence: 99%

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Shen¹,

Tian²,

Sang³

et al. 2016

Neuroimmunomodulation

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Objectives: This study was intended to investigate whether treatment with resveratrol and melatonin alone or in combination can exert neurorestorative effects in a rat model of vascular dementia. Methods: Briefly, male Wistar rats were subjected to permanent bilateral common carotid artery occlusion (BCCAO) by surgery. After 4 weeks, the cognitive deficits were assessed using the Morris water maze and novel object recognition tests. The biochemical parameters of oxidative stress and inflammation were also assessed. Results: Rats in the BCCAO group showed cognitive deficits, accompanied by oxidonitrosative stress, neuroinflammation, and a reduction in brain-derived neurotrophic factor (BDNF) in the hippocampus region. Moreover, the acetylcholinesterase activity in the hippocampus was found to be increased in the BCCAO group compared to the sham group. The 4-week treatment with melatonin (10 mg/kg) and resveratrol (20 mg/kg) alone and in combination (melatonin 5 mg/kg and reseveratrol 10 mg/kg) caused a significant improvement in the cognitive deficits induced by BCCAO, accompanied by a reversal of oxidonitrosative stress, neuroinflammation, and BDNF depletion in the hippocampus region. Additionally, the treatment with melatonin and resveratrol significantly decreased acetylcholinesterase activity compared to in the BCCAO group. Melatonin and resveratrol ameliorated the BDNF expression of hippocampal protein. Conclusion: These results emphasize that coadministration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia through changes in BDNF expressions.

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Permanent, 3-stage, 4-vessel occlusion as a model of chronic and progressive brain hypoperfusion in rats: a neurohistological and behavioral analysis

Cited by 30 publications

References 30 publications

Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Chronic Ischemia and Neurocognition

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

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