Permanent atrial fibrillation impairs the function of circulating endothelial progenitor cells

Tan, Qiang; Zhang, Shuangyue; Qi, Ximing; Zou, Xiaoyi; Sun, Qiang

doi:10.1080/00325481.2017.1288063

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…Moreover, in studies by Verdejo et al [6] and Harling et al [2], an increased blood sVCAM-1 concentration was a biomarker of AF occurrence after coronary artery bypass grafting (CABG). Associations between sVCAM-1 and AF occurrence were also reported by other authors [24][25][26][27][28][29][30][31]. In a study by Zhang et al [32], blood sVCAM-1 concen-nificant increase in the risk of all-cause mortality in the whole study group.…”

Section: Svcam-1 and Af Occurrence And Patient Prognosissupporting

confidence: 74%

Soluble vascular cell adhesion molecule-1 in patients with non-valvular atrial fibrillation

Anaszewicz

Wı́sniewska

Mieczkowski

et al. 2020

Medical Research Journal

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Background: Disturbances in atrial microcirculation is recognized as a risk factor for atrial fibrillation (AF). AIM: The aim of this study was to determine the associations between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and the risk of AF and a one-year prognosis among consecutive inpatients. Methods: Eighty consecutive inpatients hospitalized due to non-valvular AF and 80 consecutive inpatients admitted for exacerbation of chronic coronary syndrome (control group) were enrolled in the study. A cardiologic workup was performed and blood sVCAM-1 concentration was determined using the ELISA method. Results: Patients with AF had similar blood sVCAM-1 concentration compared to the control group. AF patients treated with new oral anticoagulants (NOACs) were significantly less likely to have a sVCAM-1 concentration elevated above the median value than patients treated with warfarin (34.2% vs 65.8%; p = 0.01). Patients with an increased percentage of fat mass (FM) had lower sVCAM-1 concentration. The risk of all-cause mortality and MACE during follow-up rose in individuals with elevated sVCAM-1 (≥ 1242 and

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Section: Svcam-1 and Af Occurrence And Patient Prognosissupporting

confidence: 74%

Soluble vascular cell adhesion molecule-1 in patients with non-valvular atrial fibrillation

Anaszewicz

Wı́sniewska

Mieczkowski

et al. 2020

Medical Research Journal

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“…For example, krueppel-like factor 10 (an effector of CXCR4 expression and paracrine signaling) expression is reduced by ~70 % in CD34 + /VEGFR2 + cells of peripheral arterial disease (PAD) patients, probably contributing to some of the reduced paracrine functions often observed in this and similar unhealthy/diseased populations [44]. Cultured CD34 + /VEGFR2 + cells from patients with permanent atrial fibrillation, a group with high rates of endothelial dysfunction, secreted lower levels of VEGF and NO than age-and sex-matched controls [45]. CM from CAC of critical limb ischemia patients could not elicit endothelial migration to the same degree as CAC-CM of healthy, age-matched controls [46].…”

Section: Cd34 + Cd133 +mentioning

confidence: 99%

Effects of Exercise Training on the Paracrine Function of Circulating Angiogenic Cells

et al. 2020

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Exercise training has various benefits on cardiovascular health, and circulating angiogenic cells have been proposed as executing these changes. Work from the late 1990s supported an important role of these circulating post-natal cells in contributing to the maintenance and repair of the endothelium and vasculature. It was later found that circulating angiogenic cells were a heterogenous population of cells and primarily functioned in a paracrine manner by adhering to damaged endothelium and releasing growth factors. Many studies have discovered novel circulating angiogenic cell secreted proteins, microRNA and extracellular vesicles that mediate their angiogenic potential, and some studies have shown that both acute and chronic aerobic exercise training have distinct benefits. This review highlights work establishing an essential role of secreted factors from circulating angiogenic cells and summarizes studies regarding the effects of exercise training on these factors. Finally, we highlight the various gaps in the literature in hopes of guiding future work.

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“…The level of vWF, an indicator of endothelial damage or dysfunction, was previously found to be increased in AF patients, supporting the role of endothelial dysfunction in AF (19,20). Further, the proliferation of circulating endothelial progenitor cells (EPCs), which contribute to endothelium repair by replacing damaged endothelial cells, was significantly reduced in patients with permanent AF (21). Electrical remodeling, structural remodeling caused by aging, coronary artery disease, hypertensive heart disease, diabetes mellitus and inflammation have all been suggested…”

Section: Why Are the Plasma Levels Of Vegf-a And Svegfr-1 Significantly Elevated In Af Patients?mentioning

confidence: 65%

Does an imbalance in circulating vascular endothelial growth factors (VEGFs) cause atrial fibrillation in patients with valvular heart disease?

Wang

Liu²,

Huang

et al. 2019

J Thorac Dis

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Background: The pathogenesis of atrial fibrillation (AF) remains unclear. Vascular endothelial growth factors (VEGFs) can stimulate fibrosis within the atrium and ventricle. We hypothesized that there is a relationship between the serum VEGFs/soluble vascular endothelial growth factor receptor (sVEGFRs) levels and AF in patients with valvular heart disease (VHD). This provides a new paradigm for studying AF. Methods: The plasma levels of VEGF-A, VEGF-C, sVEGFR-1 and sVEGFR-2 were detected by enzymelinked immunosorbent assay (ELISA). A total of 100 people, consisting of AF patients (long-standing, persistent AF; n=49), sinus rhythm (SR) patients (n=31) and healthy controls (n=20), were included in this study. Results:The plasma levels of VEGF-A were significantly higher in AF patients compared to healthy control (P<0.05). The plasma levels of sVEGFR-1 were significantly higher in AF compared to SR (P<0.05).The plasma levels of sVEGFR-2 were significantly lower in AF patients compared to SR patients and healthy controls (both P<0.05). There was a significant and negative correlation between AF and the sVEGFR-2 levels in the groups (r=−0.432, P=0.000).Conclusions: An imbalance in VEGFs and sVEGFRs may contribute to AF by breaking the balance of angiogenesis and lymphangiogenesis. Additionally, sVEGFR-2 may be an important biomarker of AF.

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Permanent atrial fibrillation impairs the function of circulating endothelial progenitor cells

Abstract: proliferation, tube formation and paracrine of EPCs were reduced in patients with permanent AF.

Cited by 8 publications

References 25 publications

Soluble vascular cell adhesion molecule-1 in patients with non-valvular atrial fibrillation

Soluble vascular cell adhesion molecule-1 in patients with non-valvular atrial fibrillation

Effects of Exercise Training on the Paracrine Function of Circulating Angiogenic Cells

Does an imbalance in circulating vascular endothelial growth factors (VEGFs) cause atrial fibrillation in patients with valvular heart disease?

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