Permanent chemotherapy-induced alopecia: Case report and review of the literature

Tallon, Ben; Blanchard, Elizabeth; Goldberg, Lynne J.

doi:10.1016/j.jaad.2009.06.063

Cited by 76 publications

(91 citation statements)

References 12 publications

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“…19 Although CIA is reversible in the majority of cases, permanent CIA, defined as an absence of or incomplete hair regrowth at 6 months postchemotherapy, has been reported. 20 In a recent review of the literature, Tallon et al 20 identified 7 reports of permanent alopecia after high-dose chemotherapy and bone-marrow transplantation, with busulfan frequently implicated. [21][22][23][24][25][26][27] More recently two reports have detailed permanent CIA after treatment with adjuvant chemotherapy for breast cancer, with the taxanes implicated as the most likely causative agents.…”

Section: Clinical Features Of Ciamentioning

confidence: 99%

Chemotherapy-induced alopecia

Chon

Champion²,

Geddes

et al. 2012

Journal of the American Academy of Dermatology

123

101

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Section: Clinical Features Of Ciamentioning

confidence: 99%

Chemotherapy-induced alopecia

Chon

Champion²,

Geddes

et al. 2012

Journal of the American Academy of Dermatology

123

101

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“…We believe that docetaxel was responsible for the PCIA in this case, as already suggested by other case reports. [3][4][5] The other two agents in this patient's protocol, typically associated with reversible alopecia, 6 may also have contributed to PCIA.…”

Section: Discussionmentioning

confidence: 98%

“…5 The histological picture of taxane-related permanent alopecia is consistent in all published reports. [3][4][5] Although the mode of action remains to be fully understood, topical minoxidil is known to stimulate hair growth, and has proven efficacy on AGA. 10 In a review, Messenger and Rundegren 10 suggested that minoxidil acts mainly on the hair cycle, causing premature termination of telogen, prolonging anagen.…”

Section: Discussionmentioning

confidence: 99%

“…1 Permanent chemotherapy-induced alopecia (PCIA) is uncommon, 1 and has primarily been reported with busulfan and high-dose cyclophosphamide conditioning regimens, given before bone marrow transplantation. 2 Nevertheless, cases of PCIA after taxane chemotherapy protocols for breast cancer have been recently described, [3][4][5] showing that permanent alopecia is not solely linked to high-dose chemotherapy regimens.…”

Section: Introductionmentioning

confidence: 99%

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Alopécia Permanente Pós-Quimioterapia com Resposta Favorável ao Minoxidil Tópico

Pires

Pinheiro

Lencastre

2018

SPDV

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RESUMO -A alopécia permanente pós-quimioterapia é um efeito adverso raro, classicamente associada a altas doses de quimioterapia sistémica com busulfan para transplante de medula óssea. Recentemente têm sido descritos casos de alopécia permanente pós-quimioterapia em doentes submetidos a quimioterapia sistémica com taxanos no carcinoma da mama. Na revisão da literatura não existem orientações terapêuticas consistentes para esta entidade com impacto importante na qualidade de vida dos doentes. Descreve-se o caso de uma doente de 38 anos que desenvolveu alopecia inaugural e permanente após quimioterapia com taxanos (docetaxel) para carcinoma da mama, com 2 anos de evolução à data da observação. Após 6 meses de tratamento tópico com solução de minoxidil 5%, em regime bidiário, assistiu-se a resposta clínica favorável. Os autores revêm o provável mecanismo patológico da alopécia permanente pós-quimioterapia, bem como os efeitos do minoxidil tópico no ciclo do cabelo, por forma a sustentar este fármaco como opção terapêutica a considerar neste tipo de alopecia. PALAVRAS-CHAVE -Alopecia/induzida quimicamente; Alopecia/tratamento Minoxidil; Taxanos. Case of Permanent Chemotherapy-Induced Alopecia with Response to Topical Minoxidil ABSTRACT -Permanent chemotherapy-induced alopecia is uncommon and has primarily been reported after high-dose busulfan

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“…This most commonly occurs with high dose myeloablative regimens, bleomycin and cyclophosphamide but there have also been reports of permanent alopecia associated with docetaxel regimens used in breast cancer. The incidence of permanent alopecia with docetaxel is unclear [2,3].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of the Risk of Permanent Alopecia with Docetaxel Treatment for Breast Cancer

Namini¹

2016

J Clin Case Rep

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Aim: The most commonly reported adverse reactions of docetaxel are neutropenia, anaemia, alopecia, nausea, vomiting, stomatitis, diarrhoea and asthenia. Alopecia is a distressing side-effect of cancer treatment and can have a significant negative impact on self-esteem and quality of life. The incidence of permanent alopecia with docetaxel is unclear. We reviewed available evidence relating to permanent alopecia associated with docetaxel given for the treatment of breast cancer.Method: A full literature search was performed using Medline with key words docetaxel and alopecia. Studies were included if they reported the use of docetaxel either alone or in combination regimens in breast cancer and provided information on permanent alopecia.Results: In total three papers were found. Tallon et al. reported a case of permanent alopecia in a 72-year-old caucasian female who was treated with 3 weekly adjuvant carboplatin (AUC6 650 mg), docetaxel (75 mg/m 2 ) and trastuzumab (4 mg/kg) for 6 cycles. This was followed by a year of 3 weekly trastuzumab. After her first cycle carboplatin was removed from the regimen because of severe neutropenia. She experienced scalp hair loss 2 weeks into treatment and this persisted at 13 months after completion of treatment with only minimal re-growth. A punch biopsy showed a reduction in hair follicles. She had no previous history of alopecia but was treated for hypothyroidism.

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Permanent chemotherapy-induced alopecia: Case report and review of the literature

Cited by 76 publications

References 12 publications

Chemotherapy-induced alopecia

Chemotherapy-induced alopecia

Alopécia Permanente Pós-Quimioterapia com Resposta Favorável ao Minoxidil Tópico

Systematic Review of the Risk of Permanent Alopecia with Docetaxel Treatment for Breast Cancer

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