Permanent diagnosis of bacterial vaginosis: Gram stain or Papanicolaou stain?

Giacomini, G

doi:10.1002/1097-0339(200010)23:4<292::aid-dc15>3.0.co;2-g

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…This might in part explain the controversy that Pap staining has given rise to in the international literature (8, 9, 17–19). Comparing a Pap‐stained smear sampled from only the ecto‐ and endocervix with a Gram‐stained smear taken from the fornix is not sufficient (10, 11, 20–25). In countries that routinely use triple sample collection (vaginal fornix, ecto‐ and endocervix) in cervical dysplasia screening programs, the correlation between a Pap‐stained smear and the BV diagnosis according to the Amsel criteria is very good; this is described by Vardar et al (26).…”

Section: Discussionmentioning

confidence: 99%

Validation of the use of Pap‐stained vaginal smears for diagnosis of bacterial vaginosis

Eriksson

Forsum

Bjørnerem

et al. 2007

APMIS

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Papanicolaou-stained cervicovaginal smears (Pap smears) are used to screen for cervical cancer. Since there is a lack of consensus in published reports respecting the efficacy of Pap-stained smears in BV diagnostics, there is a need to validate their use for diagnosis of BV. Slides from the international BV00 workshop were Pap stained and independently analyzed by four investigators under a phase-contrast microscope. All workshop slides--whether Pap-stained, Gram-stained or rehydrated air-dried smears--were scored according to the same Nugent classification. The diagnostic accuracy of Pap smears for diagnosis of BV had a sensitivity of 0.85 and a specificity of 0.92, with a positive and negative predictive value of 0.84 and 0.93, respectively. The interobserver weighted kappa index was 0.86 for Pap-stained smears compared to 0.81 for Gram-stained smears, and 0.70 for rehydrated air-dried smears using the mean Nugent score as the criterion standard. Provided that the samples are taken from equivalent locations (the vaginal fornix) and analyzed according to the same scoring criteria, there is no discernable difference in the diagnostic accuracy of the three smear-staining methods. The Pap-stained vaginal smears can be used as a wholly adequate alternative to Gram-stained smears for BV diagnosis.

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Section: Discussionmentioning

confidence: 99%

Validation of the use of Pap‐stained vaginal smears for diagnosis of bacterial vaginosis

Eriksson

Forsum

Bjørnerem

et al. 2007

APMIS

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“…In Pap smears, bacterial vaginosis has been recognised as a predominance of Coccobacilli 16 . It has been debated whether the use of the Pap smear is a reliable method for the detection of bacterial vaginosis, but several studies have recently concluded that the Pap smear is a superior method to Gram staining in detection of bacterial vaginosis 17–19 …”

Section: Discussionmentioning

confidence: 99%

Signs of infection in Pap smears and risk of adverse pregnancy outcome

Buchmayer¹,

Sparén²,

Cnattingius³

2003

Paediatric Perinatal Epid

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Previous studies on whether signs of infection in Pap smears imply a risk factor for preterm delivery are conflicting. In a large population-based study, we combined information from the Swedish Medical Birth Register and the Swedish Pap Smear Screening Register to investigate whether signs of infection in Pap smears increase the risks of adverse pregnancy outcomes. Logistic regression analyses were used to estimate odds ratios (OR) for antepartum death, preterm or small-for-gestational-age delivery. The presence of Coccobacilli or Trichomonas vaginalis in Pap smears increased the risk of small-for-gestational-age delivery (OR 1.3 and 1.4, respectively). Signs of infection in Pap smears were generally not associated with an increased risk of antepartum death or preterm birth. However, the presence of Coccobacilli in Pap smears within 4 weeks before delivery was associated with a more than fourfold increase in risk of very preterm delivery (< or =31 weeks, OR 4.7). This indicates that if Coccobacilli are detected in Pap smears during the second trimester, antibacterial treatment may lower the risk of very preterm delivery.

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