ABSTRACT. A 10-year old male mongrel dog was presented to the University Veterinary Teaching Hospital with a two-month history of episodic syncope. Twenty-four hr Holter electrocardiographic (ECG) recording revealed frequent episodes of advanced atrioventriculer block with long periods of ventricular asystole. The cause of syncope was determined to be Adams-Stokes syndrome exhibited bradyarrhythmia. After the animal failed to respond to medical therapy, permanent transvenous pacemaker implantation was performed. Postoperative Holter ECG showed 100 beat per min programmed pacemaker rhythm, which indicated successful capture of the artifici al pacing. The dog recovered smoothly from the operation and syncopal episodes completely disappeared. Six months after the surgery, no complications were observed and the dog's quality of life has dramatically improved. KEY WORDS: atrioventricular block, canine, pacemaker.J. Vet. Med. Sci. 65(10): 1131-1134, 2003 Implantation of artificial cardiac pacemaker is commonly used in humans for the treatment with bradyarrhythmias. In small animals, as well as in humans, pacemaker therapy has been used for the naturally occurring bradyarrhythmias, including sick sinus syndrome, persistent atrial standstill, and complete or advanced second-degree atrioventricular (AV) block [5,6]. Although reports in humans are quite extensive of pacemaker therapy, there are limited studied on the use of pacemakers in small animal practice. Thus, the indications, surgical techniques, complications and longterm outcome of pacemaker therapy in small animals have not been clearly defined. This report describes a case of pacemaker therapy in a dog with symptomatic advanced AV block.A 10-year old male mongrel dog weighing 17.0 kg was referred to the Veterinary Teaching Hospital of Tokyo University of Agriculture and Technology with a primary complaint of frequent episodes of syncope. The syncopal episodes were first seen about two months before presentation, which were increasing in frequency in spite of medical treatment with atropine and dexamethasone by a previous veterinarian. Upon presentation, the dog appeared in good health and leaned towards obesity. Findings upon neurologic examination were normal. Femoral pulses were of normal intensity but extremely irregular and the rate was below 50 beats per min (bpm). Auscultation of the heart and thoracic area did not reveal any apparent abnormalities. The dog showed sudden onset of syncope many times during the conduct of physical examination. These episodes were characterized by blinking and head shaking followed by transient loss of consciousness and collapse, sometimes accompanied by urinary incontinence, and then full recovery within 30 sec. Electrocardiography (ECG) revealed second-degree AV block which varied from 2:1 to more than 3:1 (high-grade) AV conduction (Fig. 1). The ventricular asystole persisted approximately 10 sec, and then recovered to normal AV conduction. During these periods of ventricular arrest, progressive shortening of P-P interval...