Permanent Voice Change Resulting from Danazol Therapy

Boothroyd, Clare; Lepre, F.

doi:10.1111/j.1479-828x.1990.tb03232.x

Cited by 23 publications

(19 citation statements)

References 6 publications

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“…subject 10). These changes were consistent with the literature (Mercaitis et aI., 1985;Boothroyd and Lepre, 1990) although not found to be statistically significant.…”

Section: Discussionsupporting

confidence: 94%

“…Many of these studies have relied on case study reports (Damste, 1967;Wardle and Whitehead, 1983;Mercaitis et aI., 1985;Boothroyd and Lepre, 1990;Baker, 1999) and have documented only perceptual findings (Hamblen, 1957;Epstein and Bridger, 1983;Wardle and Whitehead, 1983;Boothroyd and Lepre, 1990;Newman and Forbes, 1993).…”

Section: Introductionmentioning

confidence: 96%

“…The voice changes associated with Danazol treatment include lowering of fundamental frequency (F o )' increased frequency variability (Mercaitis et aI., 1985), voice instability, loss of high frequency, creakiness and hoarseness (Gerritsma et aI., 1994), reduced pitch control and lower pitch (Damste, 1967;Wardle and Whitehead, 1983;Baker, 1999), inflammation ' (Boothroyd and Lepre, 1990) and grey discoloration of the vocai folds (Damste, 1967). Many of these studies have relied on case study reports (Damste, 1967;Wardle and Whitehead, 1983;Mercaitis et aI., 1985;Boothroyd and Lepre, 1990;Baker, 1999) and have documented only perceptual findings (Hamblen, 1957;Epstein and Bridger, 1983;Wardle and Whitehead, 1983;Boothroyd and Lepre, 1990;Newman and Forbes, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Voice changes following androgenic hormone treatment in women

Pattie¹,

Murdoch²,

Theodoros³

2001

Asia Pacific Journal of Speech, Language and Hearing

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Androgenic medications have been known to cause changes to the vocal folds and to voice quality for many decades. One such androgen is Danazol, a synthetic derivative of testosterone. Although altered perceptual voice features have been consistently reported following treatment with Danazol, objective measurements of the voice changes have been limited. The current study incorporates a comprehensive assessment battery of vocal function including instrumental techniques, acoustic analysis and perceptual voice assessment, carried out before, during and after treatment with Danaz 01 in a group of 10 women. The results failed to indicate significant changes in the majority of voice parameters studied. Owing to the variability found in the group results it was clear that the vocal function of women prescribed androgenic hormones needs to be assessed on an individual basis.

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“…subject 10). These changes were consistent with the literature (Mercaitis et aI., 1985;Boothroyd and Lepre, 1990) although not found to be statistically significant.…”

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Voice changes following androgenic hormone treatment in women

Pattie¹,

Murdoch²,

Theodoros³

2001

Asia Pacific Journal of Speech, Language and Hearing

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“…The impact of sexual development on the voice is illustrated by the retention of feminine voice characteristics in boys who undergo orchiectomy before puberty 2 . Similarly, when androgenic agents are used in females, significant voice changes may occur 3–5 . These effects may also be seen in trained male singers with hypogonadism who are given testosterone replacement.…”

Section: Introductionmentioning

confidence: 99%

Voice Changes after Androgen Therapy for Hypogonadotrophic Hypogonadism

et al. 2004

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“…Increased levels of androgens in women may cause virilization of the larynx and the vocal folds. Voice changes caused by exogenous administration of androgens from medication or use of anabolic steroids have been identified, such as lowering of the voice pitch, loss of high frequencies, hoarse voice quality, increased instability and difficulties projecting the speaking voice . The voice usually gives information to the listener about the speaker's gender.…”

Section: Introductionmentioning

confidence: 99%