Permeability enhancement of the KcsA channel under radiation of a terahertz wave

Hu, Zhang-Hu; Lv, Wenping; Hui, De-Xuan; Wang, Xiaojuan; Wang, You‐Nian

doi:10.1103/physreve.105.024104

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…It is essential to emphasize that we utilized a classical, nonpolarized molecular dynamics simulation method. While this method is efficient and widely employed in the study of terahertz biological effects, − ,,,− it does have its limitations. Notably, it lacks the capability to account for polarization, quantum effects, and other factors.…”

Section: Methodsmentioning

confidence: 99%

“…12 The work of Hu et al demonstrated that a 0.1 THz electric field resonates with potassium ions in potassium ion channels and improves permeability, which is a novel method of regulating channel functions. 14 Our previous study found that an electric field of 15 THz could resonate with water molecules, reducing both the frozen and relaxation durations of potassium ion transmembrane movement and enhancing permeability. 29 In addition, some studies have investigated the terahertz effect of bionic artificial channels.…”

Section: Introductionmentioning

confidence: 98%

“…Regulating ion channel function is considered a means of modulating physiological processes and treating channelopathy . Research over the past few decades has indicated that ion channels can be modulated by a variety of factors, such as temperature, pH, , and electromagnetic fields. − In the context of electromagnetic fields, the terahertz wave has emerged as a recent focal point of research and is regarded as a novel tool for biological modulation. It has been proved that living organisms are sensitive to terahertz waves, as biomolecules vibrate and rotate in the terahertz band. , Therefore, terahertz is known as the light of life, and the development of terahertz technology has attracted the attention of many fields, such as physics, biology, and medicine. − Researchers are dedicated to exploring which frequencies in future terahertz technology applications might aid in disease treatments and which frequencies might need to be avoided.…”

Section: Introductionmentioning

confidence: 99%

“…A study by Tan et al found that an electric field at 34.88 THz resonates with the carbonyl group in the potassium channel selectivity filter and improves the sensitivity of the cochlea in mice, suggesting possible applications for terahertz waves in the treatment of diseases . The work of Hu et al demonstrated that a 0.1 THz electric field resonates with potassium ions in potassium ion channels and improves permeability, which is a novel method of regulating channel functions . Our previous study found that an electric field of 15 THz could resonate with water molecules, reducing both the frozen and relaxation durations of potassium ion transmembrane movement and enhancing permeability .…”

Section: Introductionmentioning

confidence: 99%

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Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Zhao,

Ding,

Wang

et al. 2024

ACS Omega

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Potassium ion channels are the structural basis for excitation transmission, heartbeat, and other biological processes. The selectivity filter is a critical structural component of potassium ion channels, whose structure is crucial to realizing their function. As biomolecules vibrate and rotate at frequencies in the terahertz band, potassium ion channels are sensitive to terahertz waves. Therefore, it is worthwhile to investigate how the terahertz wave influences the selectivity filter of the potassium channels. In this study, we investigate the structure of the selectivity filter of Kv1.2 potassium ion channels using molecular dynamics simulations. The effect of an electric field on the channel has been examined at four different resonant frequencies of the carbonyl group in SF: 36.75 37.06, 37.68, and 38.2 THz. As indicated by the results, 376GLY appears to be the critical residue in the selectivity filter of the Kv1.2 channel. Its dihedral angle torsion is detrimental to the channel structural stability and the transmembrane movement of potassium ions. 36.75 THz is the resonance frequency of the carbonyl group of 376GLY. Among all four frequencies explored, the applied terahertz electric field of this frequency has the most significant impact on the channel structure, negatively impacting the channel stability and reducing the ion permeability by 20.2% compared to the absence of fields. In this study, we simulate that terahertz waves in the mid-infrared frequency region can significantly alter the structure and function of potassium ion channels and that the effects of terahertz waves differ greatly based on frequency.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Zhao,

Ding,

Wang

et al. 2024

ACS Omega

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“…Many of the biological macromolecules that play an important role in life activities, such as proteins and phospholipids, also have vibration frequencies in the THz-FIR range ( Wetzel and LeVine, 1999 ; Laman et al, 2008 ; Miller and Dumas, 2010 ). The ion channels on the surface of the nerve membrane are not only related to action potential activity but also show that the process of ion transport across the membrane generates THz-FIR radiation ( Li et al, 2021 ; Liu et al, 2021 ; Guo et al, 2022 ; Hu et al, 2022 ; Wang et al, 2022 ). These are several potential sources for the THz-FIR signals transmitting on the nerve fibers.…”

Section: Introductionmentioning

confidence: 99%

Electromagnetic characteristics of in vivo nerve fibers at the terahertz-far-infrared band

Guo

Xu²,

Wang³

et al. 2022

Front. Bioeng. Biotechnol.

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How terahertz signals perform in the neural system has attracted widespread interest in the life sciences community. Relevant experimental reveals that in animal nerve cells, the myelin sheath of the nerve axon has a higher refractive index than the intracellular and extracellular fluids in the Terahertz-far-infrared (THz-FIR) frequency band. This makes THz-FIR wave transmission possible in nerve fibers. Based on this premise, this article carries out the following work from the theoretical level to investigate the electromagnetic (EM) characteristics of in vivo nerve fibers at the THz-FIR band. First, the EM transmission model of the nerve fibers is established and studied theoretically. The dispersion curves of THz-FIR wave modals transmission in nerve fibers are calculated, which predict that nerve fibers can act as dielectric waveguides for transmitting THz-FIR waves and the THz-FIR waves can transmit at speeds up to 108 m/s. Second, a mode matching algorithm is proposed, which is named RNMMA, to calculate the transmission characteristics of THz-FIR waves at the nodes of Ranvier. The scattering matrix obtained from the proposed algorithm is in good agreement with the results from EM simulation software, which reveals how THz-FIR signals are transmitted forward through the nodes of Ranvier with low loss.

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A Non‐Invasive and DNA‐free Approach to Upregulate Mammalian Voltage‐Gated Calcium Channels and Neuronal Calcium Signaling via Terahertz Stimulation

Sun,

Geng,

Fan

et al. 2024

Advanced Science

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Mammalian voltage‐gated calcium channels (CaV) play critical roles in cardiac excitability, synaptic transmission, and gene transcription. Dysfunctions in CaV are implicated in a variety of cardiac and neurodevelopmental disorders. Current pharmacological approaches to enhance CaV activity are limited by off‐target effects, drug metabolism issues, cytotoxicity, and imprecise modulation. Additionally, genetically‐encoded channel activators and optogenetic tools are restricted by gene delivery challenges and biosafety concerns. Here a novel terahertz (THz) wave‐based method to upregulate CaV1.2, a key subtype of CaV, and boost CaV1‐mediated Ca2+ signaling in neurons without introducing exogenous DNA is presented. Using molecular dynamics simulations, it is shown that 42.5 THz (7.05 µm, 1418 cm−1) waves enhance Ca2+ conductance in CaV1.2 by resonating with the stretching mode of the ‐COO− group in the selectivity filter. Electrophysiological recordings and Ca2+ imaging confirm that these waves rapidly, reversibly, and non‐thermally increase calcium influx of CaV1.2 in HEK293 cells and induce acute Ca2+ signals in neurons. Furthermore, this irradiation upregulates critical CaV1 signals, including CREB phosphorylation and c‐Fos expression, in vitro and in vivo, without raising significant biosafety risks. This DNA‐free, non‐invasive approach offers a promising approach for modulating CaV gating and Ca2+ signaling and treating diseases characterized by deficits in CaV functions.

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Permeability enhancement of the KcsA channel under radiation of a terahertz wave

Cited by 15 publications

References 20 publications

Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter

Electromagnetic characteristics of in vivo nerve fibers at the terahertz-far-infrared band

A Non‐Invasive and DNA‐free Approach to Upregulate Mammalian Voltage‐Gated Calcium Channels and Neuronal Calcium Signaling via Terahertz Stimulation

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